Results 321 to 330 of about 2,929,620 (353)

The Polygenic Score Catalog: new functionality and tools to enable FAIR research

Lambert SA, Wingfield B, Gibson JT, Gil L, Ramachandran S, Yvon F, Saverimuttu S, Tinsley E, Lewis E, Ritchie SC, Wu J, Canovas R, McMahon A, Harris LW, Parkinson H, Inouye M.   +15 more
europepmc   +1 more source

Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy

The FEBS Journal, EarlyView.
Neurodegeneration is thought to arise due to the disruption of the protein homeostasis. In synucleinopathies, alterations in the levels of functional and aggregated aSyn lead to proteinopenia and proteinopathy, respectively. aSyn and β‐glucocerebrosidase are closely linked to lipid metabolism, impacting organelle function and lipidostasis.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank. [PDF]

Alcohol Clin Exp Res (Hoboken)
Lai D, Kuo SI, Wetherill L, Aliev F, Zhang M, Marco A, Schwantes-An TH, Dick D, Francis MW, Johnson EC, Kamarajan C, Kinreich S, Kuperman S, Meyers J, Nurnberger JI, Liu Y, Edenberg HJ, Porjesz B, Agrawal A, Foroud T, Schuckit M, Plawecki MH, Bucholz KK, McCutcheon VV.   +23 more
europepmc   +1 more source

Effect of Transformation of Non‐Normal Fitness Trait Data on the Estimation of Genetic Parameters in Turkeys

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Fitness traits described as a ratio often display non‐normal distributions; consequently, transformations are frequently applied to improve normality prior to the estimation of genetic parameters. However, the impact of different transformations on genetic parameter estimates depends on the dataset at hand.
Evan Hartono, Owen W. Willems, Xuechun Bai, Benjamin J. Wood, Romdhane Rekaya, Samuel E. Aggrey   +5 more
wiley   +1 more source

A Systematic Review and Meta-Analysis: Research Using the Autism Polygenic Score

de Wit M, Morgan M, Libedinsky I, Austerberry C, Begeer S, Abdellaoui A, Ronald A, Polderman T.   +7 more
europepmc   +1 more source

Embracing the future: Neonatal screening for epileptic syndromes

Epilepsia, EarlyView.
Rima Nabbout, Mathieu Kuchenbuch
wiley   +1 more source

Educational Attainment Polygenic Score is Associated with Depressive Symptoms via Socioeconomic Status: A Gene-Environment-Trait Correlation

, 2019
Reut Avinun
openalex  

Pathway-based polygenic score analysis identifies the NRF2-KEAP1 and mRNA splicing - minor pathways as enriched in shared genetic variation between chronotype and bipolar disorder.

Fahey L, Lopez LM.
europepmc   +1 more source