Results 341 to 350 of about 3,197,012 (359)

Coronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events.

Journal of the American Medical Association (JAMA), 2023
Importance Coronary artery calcium score and polygenic risk score have each separately been proposed as novel markers to identify risk of coronary heart disease (CHD), but no prior studies have directly compared these markers in the same cohorts ...
S. Khan, W. Post, Xiuqing Guo, Jingyi Tan, F. Zhu, D. Bos, B. Sedaghati-khayat, Jeroen van Rooij, A. Aday, N. Allen, M. Bos, A. Uitterlinden, M. Budoff, D. Lloyd-Jones, J. Mosley, J. Rotter, P. Greenland, M. Kavousi   +17 more
semanticscholar   +1 more source

Boosting polygenic risk scores

2022
AbstractPolygenic risk scores (PRS) evaluate the individual genetic liability to a certain trait and are expected to play an increasingly important role in the field of clinical risk stratification. Most often, PRS are estimated based on summary statistics of univariate effects derived from genome-wide association studies.
Hannah Klinkhammer, Christian Staerk, Carlo Maj, Peter M. Krawitz, Andreas Mayr   +4 more
openaire   +1 more source

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer

New England Journal of Medicine
Background The incidence of prostate cancer (PrCa) is increasing. Screening by assay of prostate-specific antigen (PSA) has a high false-positive rate.
J. McHugh, Elizabeth K Bancroft, E. Saunders, M. Brook, E. Mcgrowder, S. Wakerell, D. James, R. Rageevakumar, Barbara Benton, N. Taylor, K. Myhill, M. Hogben, N. Kinsella, Aslam Sohaib, Declan Cahill, Stephen Hazell, S. Withey, N. Mcaddy, E. Page, Andrea Osborne, S. Benafif, Ann-Britt Jones, Dhruv Patel, Dean Y Huang, Kaljit Kaur, Bradley Russell, Ray Nicholson, Fionnuala Croft, Justyna Sobczak, Claire Mcnally, Fiona Mutch, Samantha Bennett, Lenita Kingston, Q. Karlsson, Tokhir Dadaev, Sibel Saya, Susan Merson, Angela Wood, N. Dennis, Nafisa Hussain, Alison Thwaites, Syed Hussain, Imran Rafi, Michelle Ferris, Pardeep Kumar, N. D. James, N. Pashayan, Z. Kote-Jarai, R. Eeles   +48 more
semanticscholar   +1 more source

Polygene risk scores and randomized experiments

Behavioral and Brain Sciences, 2023
Abstract We explore Madole & Harden's (2022) suggestion that single-nucleotide polymorphism (SNP)/trait correlations are analogous to randomized experiments and thus can be given a causal interpretation.
Lauren N. Ross, Kenneth S. Kendler, James F. Woodward   +2 more
openaire   +2 more sources

Polygenic risk score in prostate cancer

Current Opinion in Urology, 2022
Purpose of review This study was conducted in order to review the outcomes regarding polygenic risk score (PRS) in prediction of prostate cancer (PCa). With the increasing proficiency of genetic analysis, assessment of PRS for prediction of PCa has been performed in numerous studies.
Jong Jin, Oh, Sung Kyu, Hong
openaire   +2 more sources

A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities.

American Journal of Respiratory and Critical Care Medicine, 2023
RATIONALE In addition to rare genetic variants and the MUC5B locus, common genetic variants contribute to idiopathic pulmonary fibrosis (IPF) risk.
M. Moll, A. Peljto, J. S. Kim, Hanfei Xu, Catherine L. Debban, Xianfeng Chen, A. Menon, R. Putman, Auyon J. Ghosh, A. Saferali, M. Nishino, H. Hatabu, B. Hobbs, J. Hecker, G. McDermott, J. Sparks, L. Wain, R. Allen, M. Tobin, B. Raby, S. Chun, E. Silverman, A. C. Zamora, V. Ortega, C. Garcia, R. Barr, E. Bleecker, D. Meyers, R. Kaner, S. Rich, A. Manichaikul, J. Rotter, J. Dupuis, George T. O’Connor, T. Fingerlin, G. Hunninghake, D. A. Schwartz, M. Cho   +37 more
semanticscholar   +1 more source

Multi-PGS enhances polygenic prediction: weighting 937 polygenic scores

2022
AbstractThe predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effectively increased by using genetically correlated phenotypes. We propose a framework to generate multi-PGS
Clara Albiñana, Zhihong Zhu, Andrew J. Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia M. Bulik, Liselotte V. Petersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, David M. Hougaard, Thomas Werge, Anders D. Børglum, Preben Bo Mortensen, John J. McGrath, Benjamin M. Neale, Florian Privé, Bjarni J. Vilhjálmsson   +18 more
openaire   +1 more source

Polygenic Risk Scores in Human Disease

Clinical Chemistry
Abstract Background Polygenic risk scores (PRS) are measures of genetic susceptibility to human health traits. With the advent of large data repositories combining genetic data and phenotypic information, PRS are providing valuable insights into the genetic architecture of complex diseases and are ...
Dimitri J, Maamari, Roukoz, Abou-Karam, Akl C, Fahed   +2 more
openaire   +2 more sources

“Epigenomic partitioning of a polygenic risk score for asthma reveals distinct genetically driven disease pathways.” B. Stikker, L. Trap, B. Sedaghati-Khayat, et al. Eur Respir J 2024; 64: 2302059.

European Respiratory Journal
Graphical abstract Overview of the study design and key outcomes. Polygenic risk scores (PRSs) can predict asthma in a Dutch prospective cohort, in particular childhood-onset disease.
Bernard Stikker, Lianne Trap, B. Sedaghati-khayat, Marjolein J. W. de Bruijn, W. V. van Ijcken, Emmely W. de Roos, Arfan Ikram, Rudi W. Hendriks, G. Brusselle, Jeroen van Rooij, Ralph Stadhouders   +10 more
semanticscholar   +1 more source

Polygenic risk scores in kidney transplantation

Current Opinion in Organ Transplantation
Purpose of review Estimation of genetic risk is crucial for understanding heritable diseases but also transplant outcomes. Polygenic risk scores (PRSs) are constructed from genome-wide association studies (GWAS) summing an individual's risk alleles weighted by their effect size.
Kira, Jelencsics, Rainer, Oberbauer
openaire   +2 more sources