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Polygenic scores and their applications in kidney disease
Nature Reviews NephrologyGenome-wide association studies (GWAS) have uncovered thousands of risk variants that individually have small effects on the risk of human diseases, including chronic kidney disease, type 2 diabetes, heart diseases and inflammatory disorders, but cumulatively explain a substantial fraction of disease risk, underscoring the complexity and pervasive ...Atlas Khan, Krzysztof Kirylukopenaire +2 more sourcesPolygenic scores: Are they a public health hazard?
Progress in Biophysics and Molecular Biology, 2019 I argue here that polygenic scores are a public health hazard because the underlying methodology, genome wide association, from which they are derived, incorrectly assumes that the information encoded in the genomic DNA sequence is causal in terms of the cellular phenotype.openaire +3 more sourcesAssociation of polygenic score for major depression with response to lithium in patients with bipolar disorder
Molecular Psychiatry, 2020 Azmeraw T. Amare, K. Schubert, L. Hou, S. Clark, S. Papiol, Micah Cearns, U. Heilbronner, F. Degenhardt, F. Tekola-Ayele, Y. Hsu, T. Shekhtman, M. Adli, N. Akula, K. Akiyama, R. Ardau, B. Arias, J. Aubry, L. Backlund, A. Bhattacharjee, F. Bellivier, A. Benabarre, S. Bengesser, J. Biernacka, A. Birner, C. Brichant‐Petitjean, P. Cervantes, Hsi-Chung Chen, C. Chillotti, S. Cichon, C. Cruceanu, P. Czerski, N. Dalkner, A. Dayer, M. Del Zompo, J. R. DePaulo, B. Étain, S. Jamain, P. Falkai, A. Forstner, L. Frisén, M. Frye, J. Fullerton, S. Gard, J. Garnham, F. Goes, M. Grigoroiu-Serbanescu, P. Grof, R. Hashimoto, J. Hauser, S. Herms, P. Hoffmann, A. Hofmann, E. Jiménez, J. Kahn, L. Kassem, Po-Hsiu Kuo, Tadafumi Kato, J. Kelsoe, S. Kittel-Schneider, S. Kliwicki, B. König, I. Kusumi, G. Laje, M. Landén, C. Lavebratt, M. Leboyer, S. Leckband, A. Tortorella, M. Manchia, Lina Martinsson, M. McCarthy, S. McElroy, F. Colom, M. Mitjans, Francis M. Mondimore, P. Monteleone, C. Nievergelt, M. Nöthen, T. Novák, C. O’Donovan, N. Ozaki, U. Ösby, A. Pfennig, J. Potash, A. Reif, N. R. S. M. M. E. M. A. M. J. E. Wray Ripke Mattheisen Trzaskowski Byrne Abdellaoui, N. Wray, S. Ripke, M. Mattheisen, M. Trzaskowski, Enda M. Byrne, A. Abdellaoui, M. Adams, E. Agerbo, T. Air, Till F. M. Andlauer, S. Bacanu, Marie Bækvad-Hansen, A. Beekman, T. Bigdeli, E. Binder, D. Blackwood, J. Bryois, H. Buttenschøn, J. Bybjerg-Grauholm, N. Cai, E. Castelao, Jane Christensen, Toni‐Kim Clarke, J. Coleman, L. Colodro-Conde, B. Couvy-Duchesne, N. Craddock, G. Crawford, G. Davies, I. Deary, F. Degenhardt, E. Derks, N. Direk, C. Dolan, E. Dunn, T. Eley, V. Escott-Price, Farnush Farhadi Hassan Kiadeh, H. Finucane, A. Forstner, J. Frank, Héléna A. Gaspar, M. Gill, F. Goes, S. Gordon, J. Grove, L. Hall, C. Hansen, T. Hansen, S. Herms, I. Hickie, P. Hoffmann, G. Homuth, Carsten Horn, J. Hottenga, D. Hougaard, M. Ising, R. Jansen, E. Jorgenson, J. Knowles, I. Kohane, J. Kraft, Warren W. Kretzschmar, J. Krogh, Z. Kutalik, Yihan Li, P. Lind, D. Macintyre, D. MacKinnon, Robert M. Maier, W. Maier, J. Marchini, H. Mbarek, P. McGrath, P. McGuffin, S. Medland, D. Mehta, C. Middeldorp, E. Mihailov, Y. Milaneschi, L. Milani, Francis M. Mondimore, G. Montgomery, S. Mostafavi, N. Mullins, M. Nauck, B. Ng, M. Nivard, D. Nyholt, P. O’Reilly, H. Oskarsson, M. Owen, J. Painter, C. Pedersen, M. Pedersen, Roseann E. Peterson, E. Pettersson, W. Peyrot, G. Pistis, D. Posthuma, J. Quiroz, P. Qvist, J. Rice, B. Riley, M. Rivera, S. Mirza, R. Schoevers, E. Schulte, L. Shen, Jianxin Shi, Stanley I. Shyn, E. Sigurdsson, Grant C. B. Sinnamon, J. Smit, Danny J. Smith, H. Stefánsson, S. Steinberg, F. Streit, J. Strohmaier, K. Tansey, H. Teismann, A. Teumer, W. Thompson, P. Thomson, T. Thorgeirsson, M. Traylor, J. Treutlein, V. Trubetskoy, A. Uitterlinden, D. Umbricht, S. Van der Auwera, A. V. van Hemert, A. Viktorin, P. Visscher, Yunpeng Wang, B. Webb, S. Weinsheimer, J. Wellmann, G. Willemsen, S. Witt, Yang Wu, H. Xi, Jian Yang, Futao Zhang, V. Arolt, B. Baune, K. Berger, D. Boomsma, S. Cichon, U. Dannlowski, E. D. de Geus, J. R. DePaulo, E. Domenici, K. Domschke, T. Esko, H. Grabe, S. Hamilton, C. Hayward, A. Heath, K. Kendler, S. Kloiber, G. Lewis, Qingqin S. Li, S. Lucae, P. Madden, P. Magnusson, N. Martin, A. McIntosh, A. Metspalu, O. Mors, P. Mortensen, B. Müller-Myhsok, M. Nordentoft, M. Nöthen, M. O’Donovan, S. Paciga, N. Pedersen, B. Penninx, R. Perlis, D. Porteous, J. Potash, M. Preisig, M. Rietschel, C. Schaefer, T. Schulze, J. Smoller, K. Stefánsson, H. Tiemeier, R. Uher, H. Völzke, M. Weissman, T. Werge, C. Lewis, D. Levinson, G. Breen, A. Børglum, P. Sullivan, E. Reininghaus, G. Rouleau, J. Rybakowski, M. Schalling, P. Schofield, Barbara W. Schweizer, G. Severino, P. Shilling, Katzutaka Shimoda, C. Simhandl, C. Slaney, A. Squassina, T. Stamm, P. Stopková, M. Maj, G. Turecki, E. Vieta, J. Veeh, S. Witt, Adam Wright, P. Zandi, P. Mitchell, M. Bauer, M. Alda, M. Rietschel, F. McMahon, T. Schulze, B. Baune +310 moresemanticscholar +1 more sourcePolygenic risk scores for CARDINAL study
Nature Genetics, 2022 Clement A. Adebamowo, Adebowale Adeyemo, Adeyinka Ashaye, Onoja M. Akpa, Tinashe Chikowore, Ananyo Choudhury, Yasmina J. Fakim, Segun Fatumo, Neil Hanchard, Michael Hauser, Braxton Mitchell, Nicola Mulder, Solomon F. Ofori-Acquah, Mayowa Owolabi, Michèle Ramsay, Bamidele Tayo, Archana Bhavani VasanthKumar, Yuji Zhang, Sally N. Adebamowo +18 moreopenaire +2 more sources
