Results 191 to 200 of about 15,660 (211)
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Biphenyl synthase, a novel type III polyketide synthase
Planta, 2006Biphenyls and dibenzofurans are the phytoalexins of the Maloideae, a subfamily of the economically important Rosaceae. The carbon skeleton of the two classes of antimicrobial secondary metabolites is formed by biphenyl synthase (BIS). A cDNA encoding this key enzyme was cloned from yeast-extract-treated cell cultures of Sorbus aucuparia. BIS is a novel
B, Liu +3 more
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Biosynthesis of polyketides by trans-AT polyketide synthases
Natural Product Reports, 2010This review discusses the biosynthesis of natural products that are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes that have recently been recognized as one of the major group of proteins involved in the production of bioactive polyketides. 436 references are cited.
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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
Nature, 1995Modular polyketide synthases (PKSs) are complex multi-enzyme proteins that catalyse the bacterial biosynthesis of many pharmaceutically useful polyketides. The PKSs are organized into a series of modules, each containing the active catalytic sites required for one step in the synthesis process.
R, Pieper, G, Luo, D E, Cane, C, Khosla
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Tolerance and Specificity of Polyketide Synthases
Annual Review of Biochemistry, 1999▪ Abstract Polyketide synthases catalyze the assembly of complex natural products from simple precursors such as propionyl-CoA and methylmalonyl-CoA in a biosynthetic process that closely parallels fatty acid biosynthesis. Like fatty acids, polyketides are assembled by successive decarboxylative condensations of simple precursors.
C, Khosla +3 more
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Non-modular polyketide synthases in myxobacteria
Phytochemistry, 2009Myxobacteria are prolific producers of a wide variety of secondary metabolites. The vast majority of these compounds are complex polyketides which are biosynthesised by multimodular polyketide synthases (PKSs). In contrast, few myxobacterial metabolites isolated to date are derived from non-modular PKSs, in particular type III PKSs. This review reports
Yanyan, Li, Rolf, Müller
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Polyketide Synthase Genes from Marine Dinoflagellates
Marine Biotechnology, 2003Rapidly developing techniques for manipulating the pathways of polyketide biosynthesis at the genomic level have created the demand for new pathways with novel biosynthetic capability. Polyketides derived from dinoflagellates are among the most complex and unique structures identified thus far, yet no studies of the biosynthesis of dinoflagellate ...
Snyder, R. V. +6 more
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Polyketide Synthases: Mechanisms and Models
2006The modular structure of the multienzyme PKSs makes them particularly attractive targets for combinatorial biosynthesis aimed at generating novel polyketide medicines. We are beginning to understand those features of subunit organization and structure and their linking and docking elements, which are critical for productive engineering efforts ...
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Building-block selectivity of polyketide synthases
Current Opinion in Chemical Biology, 2003For the past decade, polyketide synthases have presented an exciting paradigm for the controlled manipulation of complex natural product structure. These multifunctional enzymes catalyze the biosynthesis of polyketide natural products by stepwise condensation and modification of metabolically derived building blocks.
Grace F, Liou, Chaitan, Khosla
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Polyketide Synthase Secrets Revealed
Chemical & Engineering News Archive, 2014A new study solves long-standing mysteries about how bacterial natural-product-making factories are put together and how they work. The findings could accelerate efforts to engineer these workshops to produce novel bioactive agents for drug discovery. Bacteria use huge multienzyme complexes called polyketide synthases (PKSs) to create a wide variety of
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Structures and Mechanisms of Polyketide Synthases
The Journal of Organic Chemistry, 2009Nearly a quarter-century ago, the advent of molecular genetic tools in the field of natural product biosynthesis led to the remarkable revelation that the genes responsible for the biosynthesis, regulation, and self-resistance of complex polyketide antibiotics were clustered in the genomes of the bacteria that produced these compounds.
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