Results 1 to 10 of about 186,140 (231)

Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens.

PLoS ONE, 2018
Usnic acid is a unique polyketide produced by lichens. To characterize usnic acid biosynthesis, the transcriptome of the usnic-acid-producing lichen-forming fungus Nephromopsis pallescens was sequenced using Illumina NextSeq technology.
Yi Wang, Changan Geng, Xiaolong Yuan, Mei Hua, Fenghua Tian, Changtian Li   +5 more
doaj   +2 more sources

Draft genome sequence data of Streptomyces sp. FH025

Data in Brief, 2021
: The genome data of Streptomyces sp. FH025 comprised of 8,381,474 bp with a high GC content of 72.51%. The genome contains 7035 coding sequences spanning 1261 contigs. Streptomyces sp.
Lucky Poh Wah Goh, Fauze Mahmud, Ping-Chin Lee   +2 more
doaj   +1 more source

Suppression of Tomato Bacterial Wilt Incited by Ralstonia pseudosolanacearum Using Polyketide Antibiotic-Producing Bacillus spp. Isolated from Rhizospheric Soil

Agriculture, 2022
Bacillus spp. has the potential to control bacterial and fungal diseases of crops. In vitro study, Bacillus amyloliquefaciens DSBA-11 showed best to inhibit the growth of Ralstonia pseudosolanacearum as compared to Bacillus cereus JHTBS-7, B.
Dinesh Singh, Venkatappa Devappa, Dhananjay Kumar Yadav   +2 more
doaj   +1 more source

Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

Scientific Reports, 2021
Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products will aid in the
Kei Kudo, Takehiro Nishimura, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya   +7 more
doaj   +1 more source

Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

Synthetic and Systems Biotechnology, 2020
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required ...
Tadas Jakočiūnas, Andreas K. Klitgaard, Eftychia Eva Kontou, Julie Bang Nielsen, Emil Thomsen, David Romero-Suarez, Kai Blin, Christopher J. Petzold, Jennifer W. Gin, Yaojun Tong, Charlotte Held Gotfredsen, Pep Charusanti, Rasmus J.N. Frandsen, Tilmann Weber, Sang Yup Lee, Michael K. Jensen, Jay D. Keasling   +16 more
doaj   +1 more source

The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases

Communications Biology, 2022
Structural analyses of a Streptomyces viridochromogenes product template (PT) domain suggests molecular and functional similarities with known fungal PTs involved in polyketide synthase activity.
Yuanyuan Feng, Xu Yang, Huining Ji, Zixin Deng, Shuangjun Lin, Jianting Zheng   +5 more
doaj   +1 more source

Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton

Synthetic and Systems Biotechnology, 2021
Spinosyns are natural broad-spectrum biological insecticides with a double glycosylated polyketide structure that are produced by aerobic fermentation of the actinomycete, Saccharopolyspora spinosa.
Ziheng An, Hui Tao, Yong Wang, Bingqing Xia, Yang Zou, Shuai Fu, Fang Fang, Xiao Sun, Renqiong Huang, Yao Xia, Zixin Deng, Ran Liu, Tiangang Liu   +12 more
doaj   +1 more source

Polyketides, Toxins and Pigments in Penicillium marneffei

Toxins, 2015
Penicillium marneffei (synonym: Talaromyces marneffei) is the most important pathogenic thermally dimorphic fungus in China and Southeastern Asia. The HIV/AIDS pandemic, particularly in China and other Southeast Asian countries, has led to the emergence ...
Emily W. T. Tam, Chi-Ching Tsang, Susanna K. P. Lau, Patrick C. Y. Woo   +3 more
doaj   +1 more source

Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. [PDF]

PLoS ONE, 2009
Polyketides are natural products with a wide range of biological functions and pharmaceutical applications. Discovery and utilization of polyketides can be facilitated by understanding the evolutionary processes that gave rise to the biosynthetic ...
Imke Schmitt, H Thorsten Lumbsch
doaj   +1 more source

Use of the kojA promoter, involved in kojic acid biosynthesis, for polyketide production in Aspergillus oryzae: implications for long-term production

BMC Biotechnology, 2019
Background Aspergillus oryzae, a useful industrial filamentous fungus, produces limited varieties of secondary metabolites, such as kojic acid. Thus, for the production of valuable secondary metabolites by genetic engineering, the species is considered a
Koichi Tamano, Mahoko Kuninaga, Naoshi Kojima, Myco Umemura, Masayuki Machida, Hideaki Koike   +5 more
doaj   +1 more source