Results 1 to 10 of about 21,069 (236)
Polyketide synthesis in vitro on a modular polyketide synthase [PDF]
Chemistry & Biology, 1995 The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated DEBS1-3). This complexity has hitherto frustrated mechanistic analysis of such enzymes.
Wiesmann, Kirsten E.H. +5 more
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Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens. [PDF]
PLoS ONE, 2018 Usnic acid is a unique polyketide produced by lichens. To characterize usnic acid biosynthesis, the transcriptome of the usnic-acid-producing lichen-forming fungus Nephromopsis pallescens was sequenced using Illumina NextSeq technology.
Yi Wang +5 more
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The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase [PDF]
Chemical Communications, 2017 Thiotetronate polyketide assembly by an unusual iterative synthase is reconstructedvia in vitroenzymology and chemical probes.
Marie E. Yurkovich +4 more
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Acyltransferases as Tools for Polyketide Synthase Engineering [PDF]
Antibiotics, 2018 Polyketides belong to the most valuable natural products, including diverse bioactive compounds, such as antibiotics, anticancer drugs, antifungal agents, immunosuppressants and others.
Ewa Maria Musiol-Kroll +1 more
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Draft genome sequence data of Streptomyces sp. FH025
Data in Brief, 2021 : The genome data of Streptomyces sp. FH025 comprised of 8,381,474 bp with a high GC content of 72.51%. The genome contains 7035 coding sequences spanning 1261 contigs. Streptomyces sp.
Lucky Poh Wah Goh +2 more
doaj +1 more source
The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules [PDF]
, 2016 The dimerization of multimodular polyketide synthases is essential for their function. Motifs that supplement the contacts made by dimeric polyketide synthase enzymes have previously been characterized outside the boundaries of modules, at the N- and C ...
Jianting Zheng (1616659) +4 more
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Agriculture, 2022 Bacillus spp. has the potential to control bacterial and fungal diseases of crops. In vitro study, Bacillus amyloliquefaciens DSBA-11 showed best to inhibit the growth of Ralstonia pseudosolanacearum as compared to Bacillus cereus JHTBS-7, B.
Dinesh Singh +2 more
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Structure of a modular polyketide synthase [PDF]
Nature, 2014 Polyketide natural products constitute a broad class of compounds with diverse structural features and biological activities. Their biosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in which successive modules catalyse two-carbon linear extensions and keto-group processing reactions on intermediates ...
Dutta, Somnath +10 more
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Synthetic biology of polyketide synthases [PDF]
Journal of Industrial Microbiology and Biotechnology, 2018 Abstract Complex reduced polyketides represent the largest class of natural products that have applications in medicine, agriculture, and animal health. This structurally diverse class of compounds shares a common methodology of biosynthesis employing modular enzyme systems called polyketide synthases (PKSs).
Yuzawa, Satoshi +3 more
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Evolution of polyketide synthases in bacteria [PDF]
Proceedings of the National Academy of Sciences, 2008 The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature.
Christian P, Ridley +2 more
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