Results 11 to 20 of about 21,069 (236)

Module-Based Polyketide Synthase Engineering for de Novo Polyketide Biosynthesis [PDF]

, 2023
Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and function, has the potential to produce millions of organic molecules ...
Haushalter, Robert W, Nava, Alberto A, Keasling, Jay D, Wang, Zilong, Keasling, Jay D., Haushalter, Robert W., Roberts, Jacob, Nava, Alberto A.   +7 more
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Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

Scientific Reports, 2021
Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products will aid in the
Kei Kudo, Takehiro Nishimura, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya   +7 more
doaj   +1 more source

Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]

, 2009
OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali, Mathieu, Florence, Liboz, Thierry, Bacha, Nafees, Lebrihi, Ahmed   +4 more
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Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae [PDF]

, 2009
Aspergillus westerdijkiae is the main producer of several biologically active polyketide metabolites including isoasperlactone and asperlactone. A 5298 bp polyketide synthase gene ‘‘aomsas” has been cloned in Aspergillus westerdijkiae by using gene ...
Atoui, Ali, Dobson, Alan D. W., Mathieu, Florence, Puel, Olivier, Dao, Huy Phong, Liboz, Thierry, O’Callaghan, John, O'Callaghan, John, Bacha, Nafees, Dobson, Alan D.W., Lebrihi, Ahmed   +10 more
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Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

Synthetic and Systems Biotechnology, 2020
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required ...
Tadas Jakočiūnas, Andreas K. Klitgaard, Eftychia Eva Kontou, Julie Bang Nielsen, Emil Thomsen, David Romero-Suarez, Kai Blin, Christopher J. Petzold, Jennifer W. Gin, Yaojun Tong, Charlotte Held Gotfredsen, Pep Charusanti, Rasmus J.N. Frandsen, Tilmann Weber, Sang Yup Lee, Michael K. Jensen, Jay D. Keasling   +16 more
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The Streptomyces viridochromogenes product template domain represents an evolutionary intermediate between dehydratase and aldol cyclase of type I polyketide synthases

Communications Biology, 2022
Structural analyses of a Streptomyces viridochromogenes product template (PT) domain suggests molecular and functional similarities with known fungal PTs involved in polyketide synthase activity.
Yuanyuan Feng, Xu Yang, Huining Ji, Zixin Deng, Shuangjun Lin, Jianting Zheng   +5 more
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Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton

Synthetic and Systems Biotechnology, 2021
Spinosyns are natural broad-spectrum biological insecticides with a double glycosylated polyketide structure that are produced by aerobic fermentation of the actinomycete, Saccharopolyspora spinosa.
Ziheng An, Hui Tao, Yong Wang, Bingqing Xia, Yang Zou, Shuai Fu, Fang Fang, Xiao Sun, Renqiong Huang, Yao Xia, Zixin Deng, Ran Liu, Tiangang Liu   +12 more
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Engineering Polyketide Synthases [PDF]

The Scientific World JOURNAL, 2002
Complex polyketides, exemplified by the molecules shown in Fig. 1, are produced mainly from a group of mycelia-forming bacteria belonging to the actinomycete family and have applications in medicine or agriculture. Worldwide sales of polyketides exceed $15 B annually.
openaire   +3 more sources

Iterative polyketide biosynthesis by modular polyketide synthases in bacteria [PDF]

Applied Microbiology and Biotechnology, 2015
Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is non-iterative in function.
Haotong, Chen, Liangcheng, Du
openaire   +2 more sources

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
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