Results 1 to 10 of about 27,646 (159)
Natural Polyketides Act as Promising Antifungal Agents
Biomolecules, 2023 Invasive fungal infections present a significant risk to human health. The current arsenal of antifungal drugs is hindered by drug resistance, limited antifungal range, inadequate safety profiles, and low oral bioavailability.
Hui Lu, Yuanying Jiang
exaly +3 more sources
Considerations Regarding the Cytotoxicity of Certain Classes of Fungal Polyketides—Potential Raw Materials for Skincare Products for Healthy and Diseased Skin [PDF]
PharmaceuticsBackground: This study investigates the cytotoxicity of microbial polyketides biosynthesized by Monascus species through both in silico and in vitro approaches.
Daniela Albisoru +7 more
doaj +2 more sources
From DNA Sequences to Chemical Structures – Methods for Mining Microbial Genomic and Metagenomic Data Sets for New Natural Products [PDF]
Food Technology and Biotechnology, 2010 Rapid mining of large genomic and metagenomic data sets for modular polyketide synthases, non-ribosomal peptide synthetases and hybrid polyketide synthase/non-ribosomal peptide synthetase biosynthetic gene clusters has been achieved using the generic ...
Jurica Zucko +7 more
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Molecules, 2023 The emergence of multiresistant bacteria and the shortage of antibacterials in the drug pipeline creates the need to search for novel agents. Evolution drives the optimization of the structure of marine natural products to act as antibacterial agents ...
José X. Soares +5 more
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Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases
Microbial Cell Factories, 2020 Aromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are characterized by their polycyclic aromatic structure.
Jia Wang +6 more
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Nature Communications, 2021 Trans-acyltransferase polyketide synthases are multimodular enzymes that synthesise diverse polyketides. Here, the authors present an algorithm for the global study of their diversity, showing exchange of conserved consecutive modules as a driver of ...
Eric J. N. Helfrich +10 more
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Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides
Nature Communications, 2021 Rubromycin family of natural products belongs to aromatic polyketides with diverse bioactivities, but details of their biosynthesis are limited. Here, the authors report the complete in vitro reconstitution of enzymatic formation of the spiroketal moiety
Britta Frensch +9 more
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Engineering Microbes for Plant Polyketide Biosynthesis
Computational and Structural Biotechnology Journal, 2012 Polyketides are an important group of secondary metabolites, many of which have important industrial applications, including in the food and pharmaceutical industries.
Vincent J. J. Martin +4 more
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Animal biosynthesis of complex polyketides in a photosynthetic partnership
Nature Communications, 2020 Complex polyketides are usually produced by microbes, whereas the origin of polyketides found in animals remained unknown. This study shows that sacoglossan animals, such as sea slugs, employ fatty acid synthase-like proteins to produce microbe-like ...
Joshua P. Torres +4 more
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Journal of Fungi, 2022 Six new polyketides acrucipentyns A–F (1–6) were isolated from the alga-derived fungus Asteromyces cruciatus KMM 4696. Their structures were established based on spectroscopic methods.
Olesya I. Zhuravleva +16 more
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