Results 21 to 30 of about 15,852 (221)
Marine Drugs, 2022 Four new polyketide compounds, including two new unique isocoumarins penicillol A (1) and penicillol B (2) featuring with spiroketal rings, two new citreoviridin derivatives citreoviridin H (3) and citreoviridin I (4), along with four known analogues ...
Chen Chen +6 more
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Recently Discovered Secondary Metabolites from Streptomyces Species
Molecules, 2022 The Streptomyces genus has been a rich source of bioactive natural products, medicinal chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the genus is capable of making some 150,000 more bioactive compounds than all
Heather J. Lacey, Peter J. Rutledge
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The Genetic Basis of Toxin Biosynthesis in Dinoflagellates
Microorganisms, 2019 In marine ecosystems, dinoflagellates can become highly abundant and even dominant at times, despite their comparatively slow growth rates. One factor that may play a role in their ecological success is the production of complex secondary metabolite ...
Arjun Verma +5 more
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Angewandte Chemie, EarlyView.The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Sandra A. C. Figueiredo +8 more
wiley +2 more sources
Characterization of Eight Novel Spiroleptosphols from Fusarium avenaceum
Molecules, 2019 Chemical analyses of Fusarium avenaceum grown on banana medium resulted in eight novel spiroleptosphols, T1, T2 and U−Z (1−8). The structures were elucidated by a combination of high-resolution mass spectrometric data and 1- and 2-D NMR ...
Klaus Ringsborg Westphal +11 more
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Angewandte Chemie, EarlyView.Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez +5 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Genome mining of atypical condensation (C) domains leads to the discovery of myxoglucamides, glycolipopeptides featuring an unprecedented vinyl‐substituted, α‐oxidized γ‐amino acid. Biosynthetic studies reveal a discrete C‐domain‐like O‐acyltransferase, a β‐hydroxylation‐dependent chain‐extension checkpoint, and an unusual pathway for γ‐amino acid ...
Tingting Wang +10 more
wiley +2 more sources
Nature Communications, 2017 Polyketides are secondary metabolites mainly found in aerobic organisms with wide applications in medicine and agriculture. Here, the authors uncover new polyketides native to the anaerobic bacterium Clostridium acetobutylicum and show their role in ...
Nicolaus A. Herman +5 more
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Manipulating polyketide stereochemistry by exchange of polyketide synthase modules
Chemical Communications, 2020 Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo +3 more
openaire +4 more sources
Beilstein Journal of Organic Chemistry, 2019 The synthesis of the polyketide section present in the potently cytotoxic marine cyclodepsipeptide jasplakinolide and related natural products, geodiamolides and seragamides, is reported.
Jan Hendrik Lang, Thomas Lindel
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