Results 21 to 30 of about 20,629 (261)
Marine Drugs, 2022 Six new β-resorcylic acid derivatives (1–5 and 7) were isolated from a halophyte-associated fungus, Colletotrichum gloeosporioides JS0419, together with four previously reported β-resorcylic acid lactones (RALs). The relative and absolute stereochemistry
Sunghee Bang +7 more
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Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus
Beilstein Journal of Organic Chemistry, 2021 The kingdom of fungi comprises a large and highly diverse group of organisms that thrive in diverse natural environments. One factor to successfully confront challenges in their natural habitats is the capability to synthesize defensive secondary ...
Jana M. Boysen +2 more
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Culturable Microorganisms Associated with Sea Cucumbers and Microbial Natural Products
Marine Drugs, 2021 Sea cucumbers are a class of marine invertebrates and a source of food and drug. Numerous microorganisms are associated with sea cucumbers. Seventy-eight genera of bacteria belonging to 47 families in four phyla, and 29 genera of fungi belonging to 24 ...
Lei Chen +3 more
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Engineered Biosynthesis of Alkyne-Tagged Polyketides by Type I PKSs [PDF]
, 2020 Polyketides produced by modular polyketide synthases (PKSs) are important small molecules widely used as drugs, pesticides, and biological probes. Tagging these polyketides with a clickable functionality enables the visualization, diversification, and ...
Poenateetai, Nannalin +2 more
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Engineered biosynthesis of alkyne-tagged polyketides. [PDF]
, 2022 Polyketides have demonstrated their significance as therapeutics, industrial products, pesticides, and biological probes following intense study over the past decades.
Gu, Di, Zhang, Wenjun
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Engineering microbial hosts to produce fatty-acid derived designer polyketides [PDF]
, 2023 Polyketide synthases (PKSs) are versatile multimodular enzymes that biosynthesize molecules in an assembly line fashion. The discrete and sequential processing of the polyketide intermediates by domains in PKSs give rise to our ability to ...
Valencia, Luis Enrrique
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Two New Polyketides From Streptomyces sp. SA61: Isolation, Structure Elucidation, and Insecticidal Activity Against Bemisia tabaci. [PDF]
Chem BiodiversIsolation of six polyketides (including two new compounds, strekingmycins I and J) from earthworm gut‐derived Streptomyces sp. SA61 and their insecticidal activity against third‐instar nymphs of Bemisia tabaci. Strekingmycin A (1) exhibited the most potent activity (LC50 = 5.58 µg/mL), comparable to the commercial insecticide spirotetramat. ABSTRACT To
Cui P, Chen J, Zhu Z, Liu F, Yu Z.
europepmc +2 more sources
Polyketide synthesis in vitro on a modular polyketide synthase
Chemistry & Biology, 1995 The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated DEBS1-3). This complexity has hitherto frustrated mechanistic analysis of such enzymes.
Wiesmann, Kirsten E.H. +5 more
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Iterative polyketide biosynthesis by modular polyketide synthases in bacteria [PDF]
Applied Microbiology and Biotechnology, 2015 Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is non-iterative in function.
Haotong, Chen, Liangcheng, Du
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Steroids and polyketides from Uvaria hamiltonii stem bark [PDF]
, 2004 Dva poznata steroida, stigmasterol i 6-hidroksistigmasta-4,22-dien-3-on (1) i dva neuobičajena poliketida, cis-4-hidroksimelein (2) i trans-4-hidroksimelein (3) izolirana su iz kore biljke Uvaria hamiltonii.
CHOWDHURY, RASHEDUZZAMAN +3 more
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