Results 11 to 20 of about 15,852 (221)
Biosynthesis of Polyketides in Streptomyces [PDF]
Microorganisms, 2019 Polyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti ...
Chandra Risdian +2 more
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Heterocycles, 2007 I. Introduction 1. A Plethora of Polyketides: Structures, Biological Activities, and Enzymes - Scott R. Baerson and Agnes M. Rimando II. Polyketide Biosynthesis in Plants and Microorganisms 2. Hygromycin A Biosynthesis - Nadaraj Palaniappan and Kevin Reynolds 3. The Biosynthesis of Polyketides, Tetramic Acids and Pyridones in Fungi - Russell J.
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Marine Drugs, 2021 Ten secondary metabolites, including a new grifolin analog, grifolin B (1); a new homovalencic acid derivative, 12-hydroxyhomovalencic acid (7); and a compound isolated from a natural source for the first time (9), along with seven known compounds ...
Cao Van Anh +5 more
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Marine Drugs, 2022 Six new β-resorcylic acid derivatives (1–5 and 7) were isolated from a halophyte-associated fungus, Colletotrichum gloeosporioides JS0419, together with four previously reported β-resorcylic acid lactones (RALs). The relative and absolute stereochemistry
Sunghee Bang +7 more
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Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus
Beilstein Journal of Organic Chemistry, 2021 The kingdom of fungi comprises a large and highly diverse group of organisms that thrive in diverse natural environments. One factor to successfully confront challenges in their natural habitats is the capability to synthesize defensive secondary ...
Jana M. Boysen +2 more
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Culturable Microorganisms Associated with Sea Cucumbers and Microbial Natural Products
Marine Drugs, 2021 Sea cucumbers are a class of marine invertebrates and a source of food and drug. Numerous microorganisms are associated with sea cucumbers. Seventy-eight genera of bacteria belonging to 47 families in four phyla, and 29 genera of fungi belonging to 24 ...
Lei Chen +3 more
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Sampling Terrestrial Environments for Bacterial Polyketides
Molecules, 2017 Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly as antibiotics and anticancer agents, thus the discovery of new polyketides is of major interest.
Patrick Hill +2 more
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Polyketide synthesis in vitro on a modular polyketide synthase
Chemistry & Biology, 1995 The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated DEBS1-3). This complexity has hitherto frustrated mechanistic analysis of such enzymes.
Wiesmann, Kirsten E.H. +5 more
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Iterative polyketide biosynthesis by modular polyketide synthases in bacteria [PDF]
Applied Microbiology and Biotechnology, 2015 Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases has a characteristic modular organization, and each module within a PKS carries out one cycle of polyketide chain elongation; thus each module is non-iterative in function.
Haotong, Chen, Liangcheng, Du
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A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]
Angewandte Chemie International Edition, 2018 AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Roy A. Meoded +6 more
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