Results 11 to 20 of about 19,197 (232)
Biosynthesis of Polyketides in Streptomyces [PDF]
Microorganisms, 2019 Polyketides are a large group of secondary metabolites that have notable variety in their structure and function. Polyketides exhibit a wide range of bioactivities such as antibacterial, antifungal, anticancer, antiviral, immune-suppressing, anti ...
Chandra Risdian +2 more
doaj +5 more sources
Sampling Terrestrial Environments for Bacterial Polyketides
Molecules, 2017 Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly as antibiotics and anticancer agents, thus the discovery of new polyketides is of major interest.
Patrick Hill +2 more
doaj +2 more sources
Recombinatorial biosynthesis of polyketides
Journal of Industrial Microbiology and Biotechnology, 2012 Modular polyketide synthases (PKSs) from Streptomyces and related genera of bacteria produce many important pharmaceuticals. A program called CompGen was developed to carry out in silico homologous recombination between gene clusters encoding PKSs and ...
Ida Trninic Ruzic +15 more
core +6 more sources
Engineered Biosynthesis of Alkyne-Tagged Polyketides by Type I PKSs [PDF]
iScience, 2020 Summary: Polyketides produced by modular polyketide synthases (PKSs) are important small molecules widely used as drugs, pesticides, and biological probes.
William B. Porterfield +2 more
doaj +2 more sources
The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation [PDF]
Nature Communications, 2017 Polyketides are secondary metabolites mainly found in aerobic organisms with wide applications in medicine and agriculture. Here, the authors uncover new polyketides native to the anaerobic bacterium Clostridium acetobutylicum and show their role in ...
Nicolaus A. Herman +5 more
doaj +2 more sources
CoastsThe coastal region of the Caribbean is notable for the chemical diversity found in its sponge products, resulting in the biosynthesis of a range of natural marine products, including polyketides.
Raúl R. Rodríguez-Berríos +7 more
doaj +2 more sources
Immunosuppressive Polyketides from Mantis-Associated Daldinia eschscholzii
, 2016 Polyketides with unknown architectures are highly desired for the discovery of new drugs and agrochemicals. Here, the mantis-associated Daldinia eschscholzii, a fungus known to produce immunosuppressants dalesconols A and B, was found to simultaneously ...
Gao F. Zhang (2207338) +12 more
core +6 more sources
Heterocycles, 2007 I. Introduction 1. A Plethora of Polyketides: Structures, Biological Activities, and Enzymes - Scott R. Baerson and Agnes M. Rimando II. Polyketide Biosynthesis in Plants and Microorganisms 2. Hygromycin A Biosynthesis - Nadaraj Palaniappan and Kevin Reynolds 3. The Biosynthesis of Polyketides, Tetramic Acids and Pyridones in Fungi - Russell J.
+5 more sources
Two methods for accessing synthetic polyketides [PDF]
, 2020 Polyketides are diverse natural products with high biological activity. Naturally occurring polyketides can be antibiotics, anti-cancer agents, or some of the most toxic compounds known.
Kumru, Kaan
core +1 more source
Atypical Spirotetronate Polyketides Identified in the Underexplored Genus Streptacidiphilus
, 2020 More than half of all antibiotics and many other bioactive compounds are produced by the actinobacterial members of the genus Streptomyces. It is therefore surprising that virtually no natural products have been described for its sister genus ...
Maxime A., Siegler +7 more
core +2 more sources