Results 31 to 40 of about 19,197 (232)
, 2023 Polyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many ...
Dongsoo Yang +2 more
core +1 more source
Recently Discovered Secondary Metabolites from Streptomyces Species
Molecules, 2022 The Streptomyces genus has been a rich source of bioactive natural products, medicinal chemicals, and novel drug leads for three-quarters of a century. Yet studies suggest that the genus is capable of making some 150,000 more bioactive compounds than all
Heather J. Lacey, Peter J. Rutledge
doaj +1 more source
Engineering microbial hosts to produce fatty-acid derived designer polyketides [PDF]
, 2023 Polyketide synthases (PKSs) are versatile multimodular enzymes that biosynthesize molecules in an assembly line fashion. The discrete and sequential processing of the polyketide intermediates by domains in PKSs give rise to our ability to ...
Valencia, Luis Enrrique
core
The Genetic Basis of Toxin Biosynthesis in Dinoflagellates
Microorganisms, 2019 In marine ecosystems, dinoflagellates can become highly abundant and even dominant at times, despite their comparatively slow growth rates. One factor that may play a role in their ecological success is the production of complex secondary metabolite ...
Arjun Verma +5 more
doaj +1 more source
Manipulating polyketide stereochemistry by exchange of polyketide synthase modules
Chemical Communications, 2020 Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo +3 more
openaire +4 more sources
Characterization of Eight Novel Spiroleptosphols from Fusarium avenaceum
Molecules, 2019 Chemical analyses of Fusarium avenaceum grown on banana medium resulted in eight novel spiroleptosphols, T1, T2 and U−Z (1−8). The structures were elucidated by a combination of high-resolution mass spectrometric data and 1- and 2-D NMR ...
Klaus Ringsborg Westphal +11 more
doaj +1 more source
Aniline-induced production of aniline-containing polyketides and related bicyclic polyketides by the Yellow River wetland-derived fungus Talaromyces funiculosus [PDF]
, 2023 Introduction and MethodsSilencing gene activation can effectively enrich the diversity of fungal secondary metabolites.Results and DiscussionCultivation of the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 with aniline led to the ...
Guangwei Wu +8 more
core +1 more source
Total synthesis of decarboxyaltenusin
Beilstein Journal of Organic Chemistry, 2021 The total synthesis of decarboxyaltenusin (5’-methoxy-6-methyl-[1,1’-biphenyl]-3,3’,4-triol), a toxin produced by various mold fungi, has been achieved in seven steps in a yield of 31% starting from 4-methylcatechol and 1-bromo-3,5-dimethoxybenzene ...
Lucas Warmuth +5 more
doaj +1 more source
Structural control of polyketide formation in plant-specific polyketide synthases [PDF]
Chemistry & Biology, 2000 Polyketide synthases (PKSs) generate molecular diversity by utilizing different starter molecules and by controlling the final length of the polyketide. Although exploitation of this mechanistic variability has produced novel polyketides, the structural foundation of this versatility is unclear. Plant-specific PKSs are essential for the biosynthesis of
Jez, Joseph M +5 more
openaire +2 more sources
Beilstein Journal of Organic Chemistry, 2019 The synthesis of the polyketide section present in the potently cytotoxic marine cyclodepsipeptide jasplakinolide and related natural products, geodiamolides and seragamides, is reported.
Jan Hendrik Lang, Thomas Lindel
doaj +1 more source