Results 41 to 50 of about 186,140 (231)

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

, 2016
The dimerization of multimodular polyketide synthases is essential for their function. Motifs that supplement the contacts made by dimeric polyketide synthase enzymes have previously been characterized outside the boundaries of modules, at the N- and C ...
Jianting Zheng (1616659), Borries Demeler (431852), Adrian T. Keatinge-Clay (1325979), Christopher D. Fage (1339800), David W. Hoffman (1944184)   +4 more
core   +5 more sources

The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety.

PLoS ONE, 2019
Ossamycin from Streptomyces hygroscopicus var. ossamyceticus is an antifungal and cytotoxic polyketide and a potent inhibitor of the mitochondrial ATPase.
Oksana Bilyk, Markiyan Samborskyy, Peter F Leadlay   +2 more
doaj   +1 more source

Chemoinformatic-guided engineering of polyketide synthases [PDF]

Journal of the American Chemical Society, 2019
Abstract Polyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A significant challenge in PKS design is engineering a partially reductive module to produce a saturated β-carbon through a reductive loop exchange.
Amin Zargar, Ravi Lal, Luis Valencia, Jessica Wang, Tyler William H. Backman, Pablo Cruz-Morales, Ankita Kothari, Miranda Werts, Andrew R. Wong, Constance B. Bailey, Arthur Loubat, Yuzhong Liu, Yan Chen, Samantha Chang, Veronica T. Benites, Amanda C. Hernández, Jesus F. Barajas, Mitchell G. Thompson, Carolina Barcelos, Rasha Anayah, Hector Garcia Martin, Aindrila Mukhopadhyay, Christopher J. Petzold, Edward E. K. Baidoo, Leonard Katz, Jay D. Keasling   +25 more
openaire   +4 more sources

Diversity and Distribution of Non-Reducing Polyketide Synthases (NR-PKSs) in Ascomycota (Fungi)

Journal of Fungi
(1) Background: This study highlights the diversity and distribution of non-reducing polyketide synthases (NR-PKSs) in Ascomycota and their role in producing bioactive aromatic polyketides.
Pritam Chattopadhyay, Goutam Banerjee
doaj   +1 more source

Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood

Nature Communications, 2022
2-(2-Phenylethyl)chromones (PECs) contribute to the distinctive fragrance of agarwood. Here the authors identify a diarylpentanoid-producing polyketide synthase from Aquilaria sinensis and show how it catalyzes PEC formation.
Xiao-Hui Wang, Bo-Wen Gao, Yu Nakashima, Takahiro Mori, Zhong-Xiu Zhang, Takeshi Kodama, Yuan-E Lee, Ze-Kun Zhang, Chin-Piow Wong, Qian-Qian Liu, Bo-Wen Qi, Juan Wang, Jun Li, Xiao Liu, Ikuro Abe, Hiroyuki Morita, Peng-Fei Tu, She-Po Shi   +17 more
doaj   +1 more source

Manipulating polyketide stereochemistry by exchange of polyketide synthase modules

Chemical Communications, 2020
Exchange of polyketide synthase (PKS) modules by genetic engineering leads to efficient modification of polyketide stereochemistry.
Massicard, Jean-Malo, Soligot, Claire, Weissman, Kira J., Jacob, Christophe   +3 more
openaire   +4 more sources

Don't Classify Polyketide Synthases [PDF]

Chemistry & Biology, 2004
Polyketide synthases are intensively studied as metabolite factories generating diverse biologically active natural products. Contrary to their current classification as different "types," there is now a growing body of evidence illustrating that nature realized limitless transitional stages during evolution.
openaire   +2 more sources

Isolation and characterization of polyketide drug molecule from Streptomyces species with antimicrobial activity against clinical pathogens

Journal of Infection and Public Health, 2020
Background: Natural products derived from marine microbes have more potential toward to treatment of various diseases. Among the microbes, the secondary metabolites recovered from the marine actinomycetes were more added values.
Mohammed A. Almalki
doaj   +1 more source

A hybrid modular polyketide synthase obtained by domain swapping [PDF]

, 1996
Background: Modular polyketide synthases govern the synthesis of a number of medically important antibiotics, and there is therefore great interest in understanding how genetic manipulation may be used to produce hybrid synthases that might synthesize ...
Oliynyk, Markiyan, Cortés, Jesús, Staunton, James, Brown, Murray J.B., Leadlay, Peter F.   +4 more
core   +1 more source

Benzalacetone Synthase

Frontiers in Plant Science, 2012
Benzalacetone synthase, from the medicinal plant Rheum palmatum (Polygonaceae) (RpBAS), is a plant-specific chalcone synthase (CHS) superfamily of type III polyketide synthase (PKS).
Ikuro eAbe
doaj   +1 more source