Results 41 to 50 of about 21,069 (236)
A hybrid modular polyketide synthase obtained by domain swapping [PDF]
, 1996 Background: Modular polyketide synthases govern the synthesis of a number of medically important antibiotics, and there is therefore great interest in understanding how genetic manipulation may be used to produce hybrid synthases that might synthesize ...
Oliynyk, Markiyan +4 more
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The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety.
PLoS ONE, 2019 Ossamycin from Streptomyces hygroscopicus var. ossamyceticus is an antifungal and cytotoxic polyketide and a potent inhibitor of the mitochondrial ATPase.
Oksana Bilyk +2 more
doaj +1 more source
The structure of a polyketide synthase bimodule core
Science Advances, 2022 Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid precursors. The most versatile families of PKSs are organized as assembly lines of functional modules.
Yves U. Tittes +5 more
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Mining microbial genomes for new natural products and biosynthetic pathways [PDF]
, 2008 Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
G. L. Challis, Challis, Gregory L.
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Diversity and Distribution of Non-Reducing Polyketide Synthases (NR-PKSs) in Ascomycota (Fungi)
Journal of Fungi(1) Background: This study highlights the diversity and distribution of non-reducing polyketide synthases (NR-PKSs) in Ascomycota and their role in producing bioactive aromatic polyketides.
Pritam Chattopadhyay, Goutam Banerjee
doaj +1 more source
Nature Communications, 2022 2-(2-Phenylethyl)chromones (PECs) contribute to the distinctive fragrance of agarwood. Here the authors identify a diarylpentanoid-producing polyketide synthase from Aquilaria sinensis and show how it catalyzes PEC formation.
Xiao-Hui Wang +17 more
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Polyketide Synthase Modules Redefined [PDF]
Angewandte Chemie International Edition, 2017 Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in their recent study. With this new understanding has emerged renewed hope for engineering these assembly lines to produce new materials and medicines.
openaire +2 more sources
Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity [PDF]
, 2013 Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3).
Calcinai, Barbara +24 more
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Don't Classify Polyketide Synthases [PDF]
Chemistry & Biology, 2004 Polyketide synthases are intensively studied as metabolite factories generating diverse biologically active natural products. Contrary to their current classification as different "types," there is now a growing body of evidence illustrating that nature realized limitless transitional stages during evolution.
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Chemistry of a Unique Polyketide-like Synthase [PDF]
Journal of the American Chemical Society, 2018 Like many complex natural products, the intricate architecture of saxitoxin (STX) has hindered full exploration of this scaffold's utility as a tool for studying voltage-gated sodium ion channels and as a pharmaceutical agent. Established chemical strategies can provide access to the natural product; however, a chemoenzymatic route to saxitoxin that ...
Stephanie W. Chun +3 more
openaire +2 more sources