Results 61 to 70 of about 21,069 (236)

The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds

Communications Chemistry
Modular polyketide synthases (PKSs) play a vital role in the biosynthesis of complex natural products with pharmaceutically relevant properties. Their modular architecture makes them an attractive target for engineering to produce platform chemicals and ...
Lynn Buyachuihan, Simon Reiners, Yue Zhao, Martin Grininger   +3 more
doaj   +1 more source

Genome-Based Analysis of Verticillium Polyketide Synthase Gene Clusters

Biology, 2022
Polyketides are structurally diverse and physiologically active secondary metabolites produced by many organisms, including fungi. The biosynthesis of polyketides from acyl-CoA thioesters is catalyzed by polyketide synthases, PKSs. Polyketides play roles
Mohammad Sayari, Aria Dolatabadian, Mohamed El-Shetehy, Pawanpuneet Kaur Rehal, Fouad Daayf   +4 more
doaj   +1 more source

The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases

Molecules, 2011
Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis. In modular PKSs, the polyketide chain is assembled by the successive condensation of activated carboxylic acid-derived units, where chain extension occurs with ...
Kwan, David H., Schulz, Frank
openaire   +4 more sources

Biosynthesis of polyketide synthase extender units [PDF]

Nat. Prod. Rep., 2009
This review covers the biosynthesis of extender units that are utilized for the assembly of polyketides by polyketide synthases. The metabolic origins of each of the currently known polyketide synthase extender units are covered.
Yolande A, Chan, Angela M, Podevels, Brian M, Kevany, Michael G, Thomas   +3 more
openaire   +2 more sources

Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis

mBio, 2020
Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ)
Kangmin Hua, Xiangyang Liu, Yuchun Zhao, Yaojie Gao, Lifeng Pan, Haoran Zhang, Zixin Deng, Ming Jiang   +7 more
doaj   +1 more source

Biosynthesis of coelulatin for the methylation of anthraquinone featuring HemN-like radical S-adenosyl-L-methionine enzyme

Frontiers in Microbiology, 2022
Bacterial aromatic polyketides are usually biosynthesized by the type II polyketide synthase (PKS-II) system. Advances in deoxyribonucleic acid (DNA) sequencing, informatics, and biotechnologies have broadened opportunities for the discovery of aromatic ...
Lishuang Nie, Tianyi Wei, Mingming Cao, Yunbin Lyu, Shaochen Wang, Zhiyang Feng   +5 more
doaj   +1 more source

Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

Fungal Biology and Biotechnology, 2018
Background Filamentous fungi are important producers of secondary metabolites, low molecular weight molecules that often have bioactive properties. Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have ...
Sietske Grijseels, Carsten Pohl, Jens Christian Nielsen, Zahida Wasil, Yvonne Nygård, Jens Nielsen, Jens C. Frisvad, Kristian Fog Nielsen, Mhairi Workman, Thomas Ostenfeld Larsen, Arnold J. M. Driessen, Rasmus John Normand Frandsen   +11 more
doaj   +1 more source

Engineering the Erythromycin-Producing Strain Saccharopolyspora erythraea HOE107 for the Heterologous Production of Polyketide Antibiotics

Frontiers in Microbiology, 2020
Bacteria of the genus Saccharopolyspora produce important polyketide antibiotics, including erythromycin A (Sac. erythraea) and spinosad (Sac. spinosa). We herein report the development of an industrial erythromycin-producing strain, Sac.
Jin Lü, Qingshan Long, Zhilong Zhao, Lu Chen, Weijun He, Jiali Hong, Kai Liu, Yemin Wang, Xiuhua Pang, Zixin Deng, Meifeng Tao   +10 more
doaj   +1 more source

C–N bond formation by a polyketide synthase

Nature Communications, 2023
Assembly-line polyketide synthases (PKSs) are molecular factories that produce diverse metabolites with wide-ranging biological activities. PKSs usually work by constructing and modifying the polyketide backbone successively. Here, we present the cryo-EM
Jialiang Wang, Xiaojie Wang, Xixi Li, LiangLiang Kong, Zeqian Du, Dandan Li, Lixia Gou, Hao Wu, Wei Cao, Xiaozheng Wang, Shuangjun Lin, Ting Shi, Zixin Deng, Zhijun Wang, Jingdan Liang   +14 more
doaj   +1 more source

Adaptive Genomic Divergence Across Altitudes in Capsella bursa‐pastoris

Biological Diversity, EarlyView.
Genomic divergence was observed between high‐altitude and low‐altitude populations of Capsella bursa‐pastoris in China, consistent with an important role of ecological factors. Candidate adaptive loci associated with enhanced energy metabolism, photoprotection, and growth plasticity under altitudinal stress were identified.
Lu Liu, Jia Li, Xin Liu, Xue‐Jun Ge, Hui‐Run Huang   +4 more
wiley   +1 more source