Results 61 to 70 of about 186,140 (231)

Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis

mBio, 2020
Type II polyketides are a group of secondary metabolites with various biological activities. In nature, biosynthesis of type II polyketides involves multiple enzymatic steps whereby key enzymes, including ketoacyl-synthase (KSα), chain length factor (KSβ)
Kangmin Hua, Xiangyang Liu, Yuchun Zhao, Yaojie Gao, Lifeng Pan, Haoran Zhang, Zixin Deng, Ming Jiang   +7 more
doaj   +1 more source

Biosynthesis of coelulatin for the methylation of anthraquinone featuring HemN-like radical S-adenosyl-L-methionine enzyme

Frontiers in Microbiology, 2022
Bacterial aromatic polyketides are usually biosynthesized by the type II polyketide synthase (PKS-II) system. Advances in deoxyribonucleic acid (DNA) sequencing, informatics, and biotechnologies have broadened opportunities for the discovery of aromatic ...
Lishuang Nie, Tianyi Wei, Mingming Cao, Yunbin Lyu, Shaochen Wang, Zhiyang Feng   +5 more
doaj   +1 more source

Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin

Fungal Biology and Biotechnology, 2018
Background Filamentous fungi are important producers of secondary metabolites, low molecular weight molecules that often have bioactive properties. Calbistrin A is a secondary metabolite with an interesting structure that was recently found to have ...
Sietske Grijseels, Carsten Pohl, Jens Christian Nielsen, Zahida Wasil, Yvonne Nygård, Jens Nielsen, Jens C. Frisvad, Kristian Fog Nielsen, Mhairi Workman, Thomas Ostenfeld Larsen, Arnold J. M. Driessen, Rasmus John Normand Frandsen   +11 more
doaj   +1 more source

Engineering the Erythromycin-Producing Strain Saccharopolyspora erythraea HOE107 for the Heterologous Production of Polyketide Antibiotics

Frontiers in Microbiology, 2020
Bacteria of the genus Saccharopolyspora produce important polyketide antibiotics, including erythromycin A (Sac. erythraea) and spinosad (Sac. spinosa). We herein report the development of an industrial erythromycin-producing strain, Sac.
Jin Lü, Qingshan Long, Zhilong Zhao, Lu Chen, Weijun He, Jiali Hong, Kai Liu, Yemin Wang, Xiuhua Pang, Zixin Deng, Meifeng Tao   +10 more
doaj   +1 more source

C–N bond formation by a polyketide synthase

Nature Communications, 2023
Assembly-line polyketide synthases (PKSs) are molecular factories that produce diverse metabolites with wide-ranging biological activities. PKSs usually work by constructing and modifying the polyketide backbone successively. Here, we present the cryo-EM
Jialiang Wang, Xiaojie Wang, Xixi Li, LiangLiang Kong, Zeqian Du, Dandan Li, Lixia Gou, Hao Wu, Wei Cao, Xiaozheng Wang, Shuangjun Lin, Ting Shi, Zixin Deng, Zhijun Wang, Jingdan Liang   +14 more
doaj   +1 more source

Chemistry of a Unique Polyketide-like Synthase [PDF]

Journal of the American Chemical Society, 2018
Like many complex natural products, the intricate architecture of saxitoxin (STX) has hindered full exploration of this scaffold's utility as a tool for studying voltage-gated sodium ion channels and as a pharmaceutical agent. Established chemical strategies can provide access to the natural product; however, a chemoenzymatic route to saxitoxin that ...
Stephanie W. Chun, Meagan E. Hinze, Meredith A. Skiba, Alison R. H. Narayan   +3 more
openaire   +2 more sources

Towards preparative in vitro enzymatic synthesis of new polyketide metabolites [PDF]

, 2013
textModular polyketide synthases (PKSs) are the largest enzymes known to man and are responsible for synthesizing some of the most important human medicines.
Hughes, Amanda Jane
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Investigating the Inhibitory Effects of Some Alkaloid Compounds against Aflatoxin Biosynthesis Polyketide Synthase by Molecular Docking Method

Archives of Advances in Biosciences
Introduction: Aflatoxins are toxic metabolites produced by certain fungi, primarily Aspergillus species, that contaminate various food and feed crops.
Yasin SarveAhrabi, Sarina Nejati Khoei, Mansour Bayat   +2 more
doaj   +1 more source

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster

Frontiers in Microbiology, 2015
Recently, the Aspergillus terreus terrein gene cluster was identified and selected for development of a new heterologous expression system. The cluster encodes the specific transcription factor TerR that is indispensable for terrein cluster induction. To
Markus eGressler, Peter eHortschansky, Elena eGeib, Matthias eBrock, Matthias eBrock   +4 more
doaj   +1 more source

Investigation of the post-polyketide synthase (PKS) modifications during spinosyn A biosynthesis in Saccharopolyspora spinosa [PDF]

, 2013
textDiverse biological activities of polyketide natural products are often associated with specific structural motifs, biosynthetically introduced after construction of the polyketide core. Therefore, investigation of such "post-polykektide synthase
Kim, Hak Joong, 1974-
core