Results 71 to 80 of about 21,069 (236)

Towards preparative in vitro enzymatic synthesis of new polyketide metabolites [PDF]

, 2013
textModular polyketide synthases (PKSs) are the largest enzymes known to man and are responsible for synthesizing some of the most important human medicines.
Hughes, Amanda Jane
core  

A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis [PDF]

, 2019
Polyketide synthases assemble diverse natural products with numerous important applications. The thioester intermediates in polyketide assembly are covalently tethered to acyl carrier protein domains of the synthase.
Masschelein, Joleen, Roberts, Douglas M., Yap, Zhong Ling, Christian Hobson, Joleen Masschelein, Hobson, Christian, Zhong, Ling Yap, Douglas M. Roberts, Sydor, Paulina K., Paulina K. Sydor, Parkhill, Julian, Ling Yap, Zhong, Challis, Gregory L., Jones, Cerith, Rhiannon Howe, Cerith Jones, Zhong Ling Yap, Howe, Rhiannon, Eshwar Mahenthiralingam, Gregory L. Challis, Mahenthiralingam, Eshwar, Julian Parkhill   +21 more
core   +1 more source

Investigating the Inhibitory Effects of Some Alkaloid Compounds against Aflatoxin Biosynthesis Polyketide Synthase by Molecular Docking Method

Archives of Advances in Biosciences
Introduction: Aflatoxins are toxic metabolites produced by certain fungi, primarily Aspergillus species, that contaminate various food and feed crops.
Yasin SarveAhrabi, Sarina Nejati Khoei, Mansour Bayat   +2 more
doaj   +1 more source

Incidence Trends of Early‐Onset Colorectal Cancer in Germany: A Registry‐Based Study From 2003 to 2023

International Journal of Cancer, EarlyView.
The evidence on the rising incidence of colorectal cancer among adults below 50 years of age largely stems from the United States. Using high‐quality cancer registry data for the 2003–2023 period in Germany, this study found a moderate increase of early‐onset colorectal cancer incidence that was limited to those aged 20–39 years and more pronounced ...
Sven Voigtländer, Hiltraud Kajüter, Ina Wellmann, Andras Szentkirályi, Bernd Holleczek, Volker Arndt, Jacqueline Müller‐Nordhorn, the ALSTER Working Group, Josephine Kanbach, Sabine Luttmann, Meike Ressing, Cécile Ronckers, Soo‐Zin Kim‐Wanner, Alice Nennecke, Frederik Peters, Klaus Kraywinkel, Roxana Müller‐Eberstein, Hannah Baltus, Paula Grieger, Antje Schliemann, Annika Waldmann   +20 more
wiley   +1 more source

Quantification of Fusarium graminearum and Fusarium culmorum by real-time PCR system and zearalenone assessment in maize [PDF]

, 2012
Zearalenone (ZEA) is a mycotoxin produced by some species of Fusarium, especially by Fusarium graminearum and F. culmorum. ZEA induces hyperoestrogenic responses in mammals and can result in reproductive disorders in farm animals. In the present study, a
Atoui, Ali, Kallassy, Mireille, El Khoury, André, Lebrihi, Ahmed   +3 more
core   +1 more source

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster

Frontiers in Microbiology, 2015
Recently, the Aspergillus terreus terrein gene cluster was identified and selected for development of a new heterologous expression system. The cluster encodes the specific transcription factor TerR that is indispensable for terrein cluster induction. To
Markus eGressler, Peter eHortschansky, Elena eGeib, Matthias eBrock, Matthias eBrock   +4 more
doaj   +1 more source

Draft genome sequence of antimicrobial producing Paenibacillus alvei strain MP1 reveals putative novel antimicrobials

BMC Research Notes, 2020
Objective A Paenibacillus strain isolated in previous research exhibited antimicrobial activity against relevant human pathogens including Staphylococcus aureus and Listeria monocytogenes.
Magdalena Pajor, Jonathan Sogin, Randy W. Worobo, Piotr Szweda   +3 more
doaj   +1 more source

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function [PDF]

, 2012
The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases ...
Newman, Adam G., Scheerer, Jonathan R., Belecki, Katherine, Vagstad, Anna L.   +3 more
core   +1 more source

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source