Results 51 to 60 of about 186,140 (231)

Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP. [PDF]

PLoS ONE, 2012
Modular type I polyketide synthases (PKS) produce a vast array of bacterial metabolites with highly diverse biological functions. Notably, all known polyketides were isolated from aerobic bacteria, and yet no example has been reported for strict ...
Swantje Behnken, Christian Hertweck
doaj   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Polyketide Synthase Modules Redefined [PDF]

Angewandte Chemie International Edition, 2017
Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in their recent study. With this new understanding has emerged renewed hope for engineering these assembly lines to produce new materials and medicines.
openaire   +2 more sources

Laccase and polyketide synthase genes.

, 2014
Laccase and polyketide synthase genes.
Ram Vinay Pandey (233450), Katja Sterflinger (490473), Barbara Blasi (641295), Ksenija Lopandic (641294), Albert Kriegner (34976)   +4 more
core   +1 more source

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Nature Communications, 2018
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity.
Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe   +10 more
doaj   +1 more source

Investigating A Multi-Domain Polyketide Synthase in Amphidinium carterae

Marine Drugs, 2023
Dinoflagellates are unicellular organisms that are implicated in harmful algal blooms (HABs) caused by potent toxins that are produced through polyketide synthase (PKS) pathways.
Saddef Haq, Benjamin L. Oyler, Ernest Williams, Mohd M. Khan, David R. Goodlett, Tsvetan Bachvaroff, Allen R. Place   +6 more
doaj   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

The malonyl/acetyl-transferase from murine fatty acid synthase is a promiscuous engineering tool for editing polyketide scaffolds

Communications Chemistry
Modular polyketide synthases (PKSs) play a vital role in the biosynthesis of complex natural products with pharmaceutically relevant properties. Their modular architecture makes them an attractive target for engineering to produce platform chemicals and ...
Lynn Buyachuihan, Simon Reiners, Yue Zhao, Martin Grininger   +3 more
doaj   +1 more source

Genome-Based Analysis of Verticillium Polyketide Synthase Gene Clusters

Biology, 2022
Polyketides are structurally diverse and physiologically active secondary metabolites produced by many organisms, including fungi. The biosynthesis of polyketides from acyl-CoA thioesters is catalyzed by polyketide synthases, PKSs. Polyketides play roles
Mohammad Sayari, Aria Dolatabadian, Mohamed El-Shetehy, Pawanpuneet Kaur Rehal, Fouad Daayf   +4 more
doaj   +1 more source

Structural control of polyketide formation in plant-specific polyketide synthases [PDF]

Chemistry & Biology, 2000
Polyketide synthases (PKSs) generate molecular diversity by utilizing different starter molecules and by controlling the final length of the polyketide. Although exploitation of this mechanistic variability has produced novel polyketides, the structural foundation of this versatility is unclear. Plant-specific PKSs are essential for the biosynthesis of
Jez, Joseph M, Austin, Michael B, Ferrer, Jean-Luc, Bowman, Marianne E, Schröder, Joachim, Noel, Joseph P   +5 more
openaire   +2 more sources