Results 51 to 60 of about 21,069 (236)

Isolation and characterization of polyketide drug molecule from Streptomyces species with antimicrobial activity against clinical pathogens

Journal of Infection and Public Health, 2020
Background: Natural products derived from marine microbes have more potential toward to treatment of various diseases. Among the microbes, the secondary metabolites recovered from the marine actinomycetes were more added values.
Mohammed A. Almalki
doaj   +1 more source

The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110 [PDF]

, 2012
Schwientek P, Szczepanowski R, Rückert C, et al. The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110. BMC Genomics. 2012;13(1): 112.Background Actinoplanes sp.
Szczepanowski, Rafael, Kalinowski Jörn, Rückert Christian, Selber, Klaus, Udo F Wehmeier, Christian Ruckert, Jorn Kalinowski, Jens Stoye, Wehmeier Udo F, Pühler Alfred, Stoye, Jens ; https://orcid.org/, Kalinowski, Jörn, Selber Klaus, Stoye Jens, Klein, Andreas, Klaus Selber, Alfred Puhler, Pühler, Alfred ; https://orcid.org/, Schwientek, Patrick, Schwientek Patrick, Szczepanowski Rafael, Rückert, Christian ; https://orcid.org/, Rafael Szczepanowski, Patrick Schwientek, Andreas Klein, Wehmeier, Udo F., Klein Andreas   +26 more
core   +2 more sources

Benzalacetone Synthase

Frontiers in Plant Science, 2012
Benzalacetone synthase, from the medicinal plant Rheum palmatum (Polygonaceae) (RpBAS), is a plant-specific chalcone synthase (CHS) superfamily of type III polyketide synthase (PKS).
Ikuro eAbe
doaj   +1 more source

Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the beta-Ketoacyl-ACP Synthase mtFabH [PDF]

, 2009
Background: Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population.
Johnston, Blair F., Coxon, Geoffrey D., Geoffrey D Coxon, Besra, Gurdyal S., Nahoum G Anthony, Gillespie, Stephen, Amani Alnimr, Al-Balas Qosay, Todd, MH, Coxon, GD, Gillespie Stephen H., McHugh, Timothy D., Bilal Al-Jaidi, Besra, GS, Johnston, BF, Mackay, Simon, Alnimr, Amani, Taylor, Rebecca C., Mackay Simon P., Blair F Johnston, Qosay Al-Balas, Alnimr, A, Coxon, Geoffrey, Brown, Alistair K., Simon P Mackay, Besra Gurdyal S., Mackay, SP, Taylor, RC, Gillespie, Stephen H., Johnston, Blair, Brown, Alistair, Al-Jaidi, Bilal, Al-Jaidi Bilal, McHugh, TD, Brown, AK, Anthony, Nahoum, Besra, Gurdyal; id_orcid, Besra, Gurdyal, Timothy D McHugh, McHugh, Timothy, Taylor, Rebecca, Rebecca C Taylor, Coxon Geoffrey D., Stephen H Gillespie, Alistair K Brown, Al-Balas, Q, Al-Balas, Qosay, Grainne Abbott, Abbott, Grainne, Gurdyal S Besra, Anthony, NG, Alnimr Amani, Anthony, Nahoum G., Johnston Blair F., Anthony Nahoum G., Mackay, Simon P., Taylor Rebecca C., McHugh Timothy D., Gillespie, SH, Brown Alistair K., Abbott, G, Abbott Grainne, Al-Jaidi, B   +62 more
core   +1 more source

Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP. [PDF]

PLoS ONE, 2012
Modular type I polyketide synthases (PKS) produce a vast array of bacterial metabolites with highly diverse biological functions. Notably, all known polyketides were isolated from aerobic bacteria, and yet no example has been reported for strict ...
Swantje Behnken, Christian Hertweck
doaj   +1 more source

Metagenomic Association Uncovers Host Genotype‐Structured Rhizobacterial Networks and Novel Taxa That Enhance Soybean Salt Tolerance

Advanced Science, EarlyView.
An STI‐guided metagenomic association framework links soybean salt‐tolerance phenotypes with rhizosphere microbiome composition and network organization in natural saline soils. The approach identifies candidate beneficial taxa, including Thalassospira xiamenensis, and provides an efficient strategy for mining stress‐protective microbes from native ...
Yu Luo, Feng‐Li Kang, Qi‐Min Li, Wei‐Cai Yang   +3 more
wiley   +1 more source

Evolutionary Implications of Bacterial Polyketide Synthases [PDF]

Molecular Biology and Evolution, 2005
Polyketide synthases (PKS) perform a stepwise biosynthesis of diverse carbon skeletons from simple activated carboxylic acid units. The products of the complex pathways possess a wide range of pharmaceutical properties, including antibiotic, antitumor, antifungal, and immunosuppressive activities. We have performed a comprehensive phylogenetic analysis
Holger, Jenke-Kodama, Axel, Sandmann, Rolf, Müller, Elke, Dittmann   +3 more
openaire   +2 more sources

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Nature Communications, 2018
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity.
Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe   +10 more
doaj   +1 more source

Investigating A Multi-Domain Polyketide Synthase in Amphidinium carterae

Marine Drugs, 2023
Dinoflagellates are unicellular organisms that are implicated in harmful algal blooms (HABs) caused by potent toxins that are produced through polyketide synthase (PKS) pathways.
Saddef Haq, Benjamin L. Oyler, Ernest Williams, Mohd M. Khan, David R. Goodlett, Tsvetan Bachvaroff, Allen R. Place   +6 more
doaj   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source