Results 91 to 100 of about 21,069 (236)
Nature Communications, 2023 Intermodular recognition in polyketide synthase (PKS) is a key prerequisite for catalysis and assembly-line engineering. Here, the authors present a specific domain interaction between modules and an evolution-oriented strategy for PKS engineering ...
Guifa Zhai +11 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart +7 more
wiley +1 more source
An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase [PDF]
Journal of the American Chemical Society, 2018 Polyketides are a large class of bioactive natural products with a wide range of structures and functions. Polyketides are biosynthesized by large, multidomain enzyme complexes termed polyketide synthases (PKSs). One of the primary challenges when studying PKSs is the high reactivity of their poly-β-ketone substrates.
Bryan D. Ellis +10 more
openaire +5 more sources
The FEBS Journal, EarlyView.Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner +8 more
wiley +1 more source
Investigations into the biocatalytic potential of modular polyketide synthase ketoreductases [PDF]
, 2013 textThe production of new drugs as potential pharmaceutical targets is arguably one of the most important avenues of medicine, as existing diseases not only require treatment, but it is also certain that new diseases will appear in the future which will ...
Piasecki, Shawn Kristen
core
Orchid genome evolution and trait innovation
Journal of Integrative Plant Biology, EarlyView.Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng +8 more
wiley +1 more source
Complete polyketide synthase was obtained from N. pallescens transcriptome. [PDF]
, 2018 Complete polyketide synthase was obtained from N. pallescens transcriptome.
Fenghua Tian (5532878) +5 more
core +1 more source
Journal of Phycology, EarlyView.Abstract This mini‐review examines odd‐carbon polyunsaturated fatty acids (odd‐PUFAs), a rare but biologically significant group of fatty acids in photosynthetic microorganisms. Odd‐PUFAs are straight‐chain fatty acids containing an odd number of carbon atoms and two or more methylene‐interrupted double bonds. They typically account for less than 1% of
Linda Nedbalová +2 more
wiley +1 more source
Polyketide synthase genes of P. nodorum SN15. [PDF]
, 2016 Polyketide synthase genes of P. nodorum SN15.
Kar-Chun Tan (259577) +12 more
core +1 more source
Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening
Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker +3 more
wiley +2 more sources