Results 111 to 120 of about 21,069 (236)

Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli

Microbial Cell Factories, 2020
Background Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial effects. Certain plant species such
Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim, Joong-Hoon Ahn   +3 more
doaj   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Draft genome sequence of the oxytetracycline-producing bacterium streptomyces rimosus ATCC 10970 [PDF]

, 2013
We report the draft genome of Streptomyces rimosus (ATCC 10970), the soil isolate that produces oxytetracycline, a commercially important and clinically useful antibiotic.
Alison C. MacFadyen, Iain S. Hunter, Herron, Paul R., Gregor Kosec, Sangal, Vartul, Tang, Zhenyu, Florence E. Pethick, Ralph Kirby, Chu, Ju, Paul R. Herron, Zhenyu Tang, Hrvoje Petkovic, Hunter, Iain, Hunter, Iain S., Guo, Meijin, Petkovic, Hrvoje, Kirby, Ralph, Ju Chu, MacFadyen, Alison C., Pethick, Florence, Meijin, Guo, Pethick, Florence E., Vartul Sangal, Liu, Tze-Tze, Meijin Guo, Hoskisson, Paul A., Petkovic, H., Tze-Tze Liu, Herron, Paul, Hoskisson, Paul, MacFadyen, Alison, Paul A. Hoskisson, Kirby, R., Kosec, Gregor   +33 more
core   +1 more source

Deciphering the Function and Structure of PA1216 as an S‐Adenosyl‐l‐Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microbes produce bioactive secondary metabolites as toxins, pigments, or virulence factors. These specialized compounds are produced by nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), or hybrid NRPS/PKS pathways. The genes encoding NRPS and PKS reside in biosynthetic gene clusters (BGCs), some of which have no identified ...
Amaan M. Fruitwala, Jade X. Tiszler, Daniel Watson, Mansi Sinha, Tony D. Davis   +4 more
wiley   +1 more source

Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates

Marine Drugs, 2008
Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously ...
Kathleen S. Rein, Tianying An, Jose Lopez, Li Liu, Roberto Perez   +4 more
doaj  

Total Synthesis and Stereochemical Assignment of Alternapyrone

Molecules
Alternapyrone, a bioactive polyketide produced by the fungal host Aspergillus oryzae, is biosynthesized by a polyketide synthase encoded by the alt1-5 gene cluster.
Hui Zhang, Jiaxuan Feng, Di Wang, Bencan Tang, Chao Xu, Tao Ye   +5 more
doaj   +1 more source

Draft Genome Sequence of a Chitinase-Producing Biocontrol Bacterium, Lysobacter antibioticus HS124

Research in Plant Disease, 2014
Lysobacter antibiocus HS124 is a chitinase-producing rhizobacterium with proven capacities to suppress plant diseases. Bacterial cultures of L. antibioticus HS124 showed strong biocontrol efficacies against various plant diseases compared to those of ...
Brian B. McSpadden Gardener, In Seon Kim, Kil Yong Kim, Young Cheol Kim   +3 more
doaj   +1 more source

Barley HvBODYGUARD1 controls cuticular specialisations regulated by SHINE transcription factors

New Phytologist, Volume 251, Issue 3, Page 1188-1208, August 2026.
Cuticle defects result from defective HvBDG1 alleles. Summary Land plants secrete a protective outer cuticular layer with diverse functions. Barley (Hordeum vulgare L.) develops two cuticular specialisations: the β‐diketone rich wax bloom on vegetative tissues and an adherent grain surface which sticks to the hulls, leading to barley's distinctive ...
Trisha McAllister, Chiara Campoli, Linsan Liu, Tansy Chia, S. Ronan Fisher, Richard Horsnell, Alan R. Prescott, Jennifer Shoesmith, Mhmoud Eskan, Alasdair Iredale, Mirjam Nuter, Luke Ramsay, Micha M. Bayer, Linda Milne, Miriam Schreiber, Yogeswari Rajarathinam, Vanessa Wahl, Robbie Waugh, James Cockram, Sarah M. McKim   +19 more
wiley   +1 more source

Broad Substrate Specificity of the Loading Didomain of the Lipomycin Polyketide Synthase [PDF]

, 2016
LipPks1, a polyketide synthase subunit of the lipomycin synthase, is believed to catalyze the polyketide chain initiation reaction using isobutyryl-CoA as a substrate, followed by an elongation reaction with methylmalonyl-CoA to start the biosynthesis of
Satoshi Yuzawa (1744645), Leonard Katz (640323), Jay D. Keasling (51716), Clara H. Eng (1952680)   +3 more
core   +1 more source

Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus

Small Structures
The biosynthesis of pseurotin A, a fungal metabolite with antibiotic and immunosuppressive properties, involves a group of enzymes, including a polyketide‐nonribosomal peptide synthase (PKS‐NRPS), PsoA, and a bifunctional enzyme, PsoF. PsoA consists of a
Lei Sun, Zi‐Long You, Rui‐Qing Lyu, Zhao‐Bin Wang, Ming Ma, Lin Bai   +5 more
doaj   +1 more source