Results 131 to 140 of about 21,069 (236)
Structure and mechanism of chalcone synthase-like polyketide synthases
Journal of Industrial Microbiology and Biotechnology, 2001 Polyketide synthases (PKS) produce an array of natural products with different biological activities and pharmacological properties by varying the starter and extender molecules that form the final polyketide. Recent studies of the simplest PKS, the chalcone synthase (CHS)-like enzymes involved in the biosynthesis of flavonoids, anthocyanin pigments ...
J M, Jez +6 more
openaire +2 more sources
Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase [PDF]
, 2011 HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential.
Makoto Yamashita +8 more
core +1 more source
Module-Based Polyketide Synthase Engineering for de Novo Polyketide Biosynthesis [PDF]
Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and function, has the potential to produce millions of organic molecules ...
Alberto A. Nava (17271805) +4 more
core +3 more sources
Microbial Biotechnology, Volume 19, Issue 7, July 2026.CI‐ARS3, a dual silencing platform, achieves over 97% suppression of aminoglycoside biosynthesis in Streptomyces without significant off‐target effects, thereby facilitating the discovery of novel antimicrobials that were previously masked. ABSTRACT Streptomyces species are prolific sources of antimicrobials, yet their vast biosynthetic capacity ...
Yuncong Xu +8 more
wiley +1 more source
Microbial Biotechnology, Volume 19, Issue 7, July 2026.Systematic functional characterization of all eight GATA‐type transcription factors in the nematode‐trapping fungus Arthrobotrys flagrans reveals a novel, light‐independent WC1/WC2–Sre1 transcriptional cascade that orchestrates both trap formation and chlamydospore development, providing actionable targets for engineering superior biocontrol strains ...
Yu Zhang +6 more
wiley +1 more source
Characterizing structure and function of thioesterase from polyketide synthase [PDF]
, 2010 Polyketides are a large class of structurally diverse natural products with important biological activities. A number of commercially available drugs are developed from polyketides, such as simvastin, erythromycin and tetracyclines.
Wang, Meng
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Plant Pathology, Volume 75, Issue 4, July‐August 2026.Three Ramularia collo‐cygni strains, differing in rubellin D production, varied in virulence on two barley cultivars, with symptom development correlating with rubellin D biosynthesis in the most susceptible cultivar. The role of this phytotoxin in fungal aggressivity and possible involvement of other secondary metabolites is discussed.
Emilio Balducci +7 more
wiley +1 more source
Strobilurin biosynthesis in Basidiomycete fungi
Nature Communications, 2018 Strobilurins are fungal metabolites that inspired the creation of β-methoxyacrylate agricultural fungicides. Here, Nofiani et al. identify the strobilurin biosynthesis gene cluster, encoding a polyketide synthase as well as an FAD-dependent oxygenase for
Risa Nofiani +8 more
doaj +1 more source
Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2–dependent statine pathway
Nature CommunicationsPepstatins are potent inhibitors of aspartic proteases, featuring two statine residues crucial for target binding. However, the biosynthesis of pepstatins, especially their statine substructure, remains elusive.
Jingjun Mo +7 more
doaj +1 more source
Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively [PDF]
, 1999 The assembly of the polyketide backbone of rifamycin B on the type I rifamycin polyketide synthase (PKS), encoded by the rifA-rifE genes, is terminated by the product of the rifF gene, an amide synthase that releases the completed undecaketide as its ...
Hutchinson, C. R. +8 more
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