Results 131 to 140 of about 186,140 (231)

Characterizing structure and function of thioesterase from polyketide synthase

, 2010
Polyketides are a large class of structurally diverse natural products with important biological activities. A number of commercially available drugs are developed from polyketides, such as simvastin, erythromycin and tetracyclines.
Wang, Meng
core   +1 more source

Syntheses of Conjugated Pyrones for the Enzymatic Assay of Lovastatin Nonaketide Synthase, an Iterative Polyketide Synthase

, 2016
Lovastatin nonaketide synthase (LovB, LNKS) is an iterative type I polyketide synthase (PKS) from Aspergillus terreus that produces dihydromonacolin L (2), the biosynthetic precursor of lovastatin (1), from acetyl CoA, malonyl CoA, and S ...
John C. Vederas (174316), Xuan B. Chen (2511511), Douglas A. Burr (2335150)   +2 more
core   +1 more source

Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2–dependent statine pathway

Nature Communications
Pepstatins are potent inhibitors of aspartic proteases, featuring two statine residues crucial for target binding. However, the biosynthesis of pepstatins, especially their statine substructure, remains elusive.
Jingjun Mo, Asfandyar Sikandar, Haowen Zhao, Ghader Bashiri, Liujie Huo, Martin Empting, Rolf Müller, Chengzhang Fu   +7 more
doaj   +1 more source

Module-Based Polyketide Synthase Engineering for de Novo Polyketide Biosynthesis

Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and function, has the potential to produce millions of organic molecules ...
Alberto A. Nava (17271805), Zilong Wang (404828), Jacob Roberts (15294308), Jay D. Keasling (51716), Robert W. Haushalter (1345209)   +4 more
core   +2 more sources

Dissection and Engineering of Modular Polyketide Synthase Extender Unit Specificity Motifs. [PDF]

Chembiochem
Welch S, Williams GJ.
europepmc   +1 more source

Polyketide Synthases

Acta Scientific Microbiology, 2019
openaire   +1 more source

Polyketide synthase-like functionality acquired by plant fatty acid elongase. [PDF]

Sci Adv
Kim H, Park K, Jia H, Huang F, Tang X, Zhong T, Yu W, Riethoven JM, Cahoon RE, Zhang C, Cahoon EB.   +10 more
europepmc   +1 more source

Polyketide synthase-based controlled synthesis of polycyclopropanated fuel molecules. [PDF]

Nat Commun
Yin K, Landera A, Lee N, Iavarone AT, Kosina SM, Young TD, Deng K, Baerwald J, Chen Y, Gin JW, Benedict R, Chiu Y, Ukabiala E, Kamruzzaman M, Poorey K, Northen TR, Petzold CJ, George A, Cruz-Morales P, Dan Q, Keasling JD.   +20 more
europepmc   +1 more source

Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase [PDF]

RSC Chem Biol
Foran ME, Ho YTC, Lewandowski JR, Jenner M.   +3 more
europepmc   +2 more sources

Extending the starter-unit selection of a collaborating non-reducing polyketide synthase through rational domain swaps. [PDF]

RSC Adv
Yin R, Zhang M, Zhai Z, Qin Y, Liang X, Xu D, Zhou L, Lai D.   +7 more
europepmc   +1 more source