Results 21 to 30 of about 21,069 (236)

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]

Angewandte Chemie International Edition, 2018
AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Roy A. Meoded, Reiko Ueoka, Eric J. N. Helfrich, Katja Jensen, Nancy Magnus, Birgit Piechulla, Jörn Piel   +6 more
openaire   +5 more sources

Synthetic biology of fungal natural products [PDF]

, 2015
This work was supported by the DFG-funded excellence graduate school Jena School for Microbial Communication (JSMC; DJM, AAB), the collaborative research center (SFB) 1127 Chemical Mediators in Complex Biosystems (ChemBioSys—AAB, project B02) and the ...
Vito Valiante, Unkles, S.E., Mattern, D.J., Valiante, V., Brakhage, A.A., Derek J. Mattern, Axel A. Brakhage, Shiela E. Unkles   +7 more
core   +1 more source

Polyketides, Toxins and Pigments in Penicillium marneffei

Toxins, 2015
Penicillium marneffei (synonym: Talaromyces marneffei) is the most important pathogenic thermally dimorphic fungus in China and Southeastern Asia. The HIV/AIDS pandemic, particularly in China and other Southeast Asian countries, has led to the emergence ...
Emily W. T. Tam, Chi-Ching Tsang, Susanna K. P. Lau, Patrick C. Y. Woo   +3 more
doaj   +1 more source

Ancient horizontal gene transfer from bacteria enhances biosynthetic capabilities of fungi. [PDF]

PLoS ONE, 2009
Polyketides are natural products with a wide range of biological functions and pharmaceutical applications. Discovery and utilization of polyketides can be facilitated by understanding the evolutionary processes that gave rise to the biosynthetic ...
Imke Schmitt, H Thorsten Lumbsch
doaj   +1 more source

Use of the kojA promoter, involved in kojic acid biosynthesis, for polyketide production in Aspergillus oryzae: implications for long-term production

BMC Biotechnology, 2019
Background Aspergillus oryzae, a useful industrial filamentous fungus, produces limited varieties of secondary metabolites, such as kojic acid. Thus, for the production of valuable secondary metabolites by genetic engineering, the species is considered a
Koichi Tamano, Mahoko Kuninaga, Naoshi Kojima, Myco Umemura, Masayuki Machida, Hideaki Koike   +5 more
doaj   +1 more source

Identification of a polyketide synthase required for alternariol (AOH) and alternariol-9-methyl ether (AME) formation in Alternaria alternata. [PDF]

PLoS ONE, 2012
Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins.
Debjani Saha, Ramona Fetzner, Britta Burkhardt, Joachim Podlech, Manfred Metzler, Ha Dang, Christopher Lawrence, Reinhard Fischer   +7 more
doaj   +1 more source

Laccase and polyketide synthase genes. [PDF]

, 2014
Laccase and polyketide synthase genes.
Ram Vinay Pandey (233450), Katja Sterflinger (490473), Barbara Blasi (641295), Ksenija Lopandic (641294), Albert Kriegner (34976)   +4 more
core   +1 more source

A novel class of plant type III polyketide synthase involved in orsellinic acid biosynthesis from Rhododendron dauricum

Frontiers in Plant Science, 2016
Rhododendron dauricum L. produces daurichromenic acid, the anti-HIV meroterpenoid consisting of sesquiterpene and orsellinic acid moieties. To characterize the enzyme responsible for orsellinic acid biosynthesis, a cDNA encoding a novel polyketide ...
Futoshi Taura, Miu Iijima, Eriko Yamanaka, Hironobu Takahashi, Hiromichi Kenmoku, Haruna Saeki, Satoshi Morimoto, Yoshinori Asakawa, Fumiya Kurosaki, Hiroyuki Morita   +9 more
doaj   +1 more source

Polymorphism of the Polyketide Synthase Gene phlD in Biocontrol Fluorescent Pseudomonads Producing 2,4-Diacetylphloroglucinol and Comparison of PhlD with Plant Polyketide Synthases [PDF]

, 2001
Many biocontrol fluorescent pseudomonads can protect plants from soilborne fungal pathogens through production of the antifungal secondary metabolite 2,4-diacetylphloroglucinol (Phl). One of the phl biosynthetic genes, phlD, encodes a polyketide synthase
Ramette, Alban Nicolas, Moënne-Loccoz, Yvan, Défago, Geneviève   +2 more
core   +1 more source

Cleaning up Polyketide Synthases

Chemistry & Biology, 2012
Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates from a multi-enzyme complex. This activity might find use in understanding polyketide biosynthesis,
Kwan, Jason C., Schmidt, Eric W.
openaire   +2 more sources