Results 201 to 210 of about 15,660 (211)

Novel applications of plant polyketide synthases

Current Opinion in Chemical Biology, 2012
The structurally and mechanistically simple type III polyketide synthases (PKSs) catalyze iterative condensations of CoA thioesters to produce a variety of polyketide scaffolds with remarkably diverse structures and biological activities. By exploiting the enzymes, we combined precursor-directed biosynthesis with nitrogen-containing substrates and ...
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The Chalcone Synthase Superfamily of Type III Polyketide Synthases

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael B, Austin, Joseph P, Noel
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Chalcone synthases (CHSs): the symbolic type III polyketide synthases

Planta, 2019
Present review provides a thorough insight on some significant aspects of CHSs over a period of about past three decades with a better outlook for future studies toward comprehending the structural and mechanistic intricacy of this symbolic enzyme. Polyketide synthases (PKSs) form a large family of iteratively acting multifunctional proteins that are ...
Shahzad A, Pandith, Salika, Ramazan, Mohd Ishfaq, Khan, Zafar A, Reshi, Manzoor A, Shah   +4 more
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Manipulation and Analysis of Polyketide Synthases

2004
Publisher Summary This chapter examines the manipulation and analysis of polyketide (PKS) synthases. PKS span a large range of medicinally important com-pounds, such as antibiotics, anticancer agents, immunosuppressants, and cholesterol-lowering agents.
Pawan, Kumar, Chaitan, Khosla, Yi, Tang
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Type III Polyketide Synthases in Microorganisms

2012
Type III polyketide synthases (PKSs) are simple homodimers of ketosynthases which catalyze the condensation of one to several molecules of extender substrate onto a starter substrate through iterative decarboxylative Claisen condensation reactions. Type III PKSs have been found in bacteria and fungi, as well as plants.
Yohei, Katsuyama, Yasuo, Ohnishi
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Heterologous expression systems for polyketide synthases

Nat. Prod. Rep., 2009
Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs.
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Hybrid Type I and II Polyketide Synthases Yield Distinct Aromatic Polyketides

Journal of the American Chemical Society
ABSTRACTBacterial aromatic polyketides are compounds with multiple aromatic rings synthesized by bacterial type II polyketide synthases (PKSs), some of which have been developed into clinical drugs. Compounds containing aromatic polyketides synthesized by a hybrid type I and type II PKSs are extremely rare.
Li Ya Zhao, Jing Shi, Zhao Yang Xu, Jia Lin Sun, Zhang Yuan Yan, Zhi Wu Tong, Ren Xiang Tan, Rui Hua Jiao, Hui Ming Ge   +8 more
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The erythromycin-producing polyketide synthase

Biochemical Society Transactions, 1993
P F, Leadlay, J, Staunton, J F, Aparicio, D J, Bevitt, P, Caffrey, J, Cortes, A, Marsden, G A, Roberts   +7 more
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Manipulation of Modular Polyketide Synthases

Chemical Reviews, 1997
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Genetic Contributions to Understanding Polyketide Synthases

Chemical Reviews, 1997
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