Results 71 to 80 of about 2,099,251 (265)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Propriétés mécaniques des mousses polymères : influence de l'architecture interne sur les raideurs

, 2017
Les mousses à cellules fermées sont constituées d'un ensemble de bulles de gaz séparées par de fines membranes d'une phase solide plus ou moins rigide.
Gauthier, Christian, Dabo, Mouhamadou, Roland, Thierry, Dalongeville, Gaétan   +3 more
core  

Modèle de prédiction de la dégradation des matériaux polymères en milieu réel

Sciences, Eaux & Territoires, 2000
Le développement de polymères biodégradables, pour l'emballage et les produits d'usage courant a pris un intérêt considérable. Cependant, dire qu'un matériau est biodégradable nécessite d'évaluer son taux de biodégradabilité. L'objectif de ce travail est
A. CALMON, F. SILVESTRE, V. BELLON-MAUREL, P. FEUILLOLEY   +3 more
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Modélisation d’un nouveau type de mélangeur de polymères

, 2009
Colloque avec actes et comité de lecture. Internationale.International audienceLes outils utilisés dans la mise en œuvre des polymères génèrent essentiellement des écoulements de cisaillement.
Loux, Cyril, Bouchet, Gilles, Bouquey, Michel, Muller, René   +3 more
core   +1 more source

Synthesis of mesogenic phthalocyanine-C60 donor–acceptor dyads designed for molecular heterojunction photovoltaic devices

Beilstein Journal of Organic Chemistry, 2009
A series of phthalocyanine-C60 dyads 2a–d was synthesized. Key steps in their synthesis are preparation of the low symmetry phthalocyanine intermediate by the statistical condensation of two phthalonitriles, and the final esterification of the fullerene ...
Yves Henri Geerts, Olivier Debever, Claire Amato, Sergey Sergeyev   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Switchable supramolecular helices for asymmetric stereodivergent catalysis

Nature Communications
Despite recent developments on the design of dynamic catalysts, none of them have been exploited for the in-situ control of multiple stereogenic centers in a single molecular scaffold.
Ran Chen, Ahmad Hammoud, Paméla Aoun, Mayte A. Martínez-Aguirre, Nicolas Vanthuyne, Régina Maruchenko, Patrick Brocorens, Laurent Bouteiller, Matthieu Raynal   +8 more
doaj   +1 more source