Results 51 to 60 of about 504 (149)

Influence of Processing and Storage on the Shear Thickening Properties of Highly Concentrated Monodisperse Silica Particles in Polyethylene Glycol

Applied Rheology, 2013
The shear thickening behavior of concentrated suspensions can be exploited to dissipate energy during impact or shear loading. To preserve the consistency of the thickening behavior in practical applications, particle concentration, and dispersion should
Soutrenon Mathieu, Michaud Veronique, Manson Jan-Anders E.   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Thermal and mechanical performances of bamboo strip

Materials Research Express, 2021
Bamboo strips extracted from Phyllostachys viridiglaucescens, grown in Europe, were analysed to assess their thermal and mechanical properties for composites application. Thermal stability of the European bamboo was studied by Thermogravimetric Analysis (
Tutea Richmond, Louise Lods, Jany Dandurand, Eric Dantras, Colette Lacabanne, Jean-Michel Durand, Edouard Sherwood, Philippe Ponteins   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Ionic Liquids-Containing Silica Microcapsules: A Potential Tunable Platform for Shaping-Up Epoxy-Based Composite Materials?

Nanomaterials, 2020
In this work, silica microcapsules containing phosphonium ionic liquid (IL), denoted SiO2@IL, were successfully synthesized for the first time using the one step sol-gel method in IL/H20 emulsion.
Ting Shi, Sébastien Livi, Jannick Duchet, Jean-François Gérard   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Modèle de prédiction de la dégradation des matériaux polymères en milieu réel

Sciences, Eaux & Territoires, 2000
Le développement de polymères biodégradables, pour l'emballage et les produits d'usage courant a pris un intérêt considérable. Cependant, dire qu'un matériau est biodégradable nécessite d'évaluer son taux de biodégradabilité. L'objectif de ce travail est
A. CALMON, F. SILVESTRE, V. BELLON-MAUREL, P. FEUILLOLEY   +3 more
doaj