Results 101 to 110 of about 6,325,712 (326)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Tumor-Targeting Polymer–Drug Conjugate for Liver Cancer Treatment In Vitro

, 2022
Bufalin (buf) has poor solubility in aqueous solution, poor tumor targeting, and many non-specific toxic and side effects. The advantages of high-molecular-weight polymer conjugates are that they can improve the water solubility of buf, prolong plasma ...
Jiankun Xu, Qi Xing, Hao Hu, Shanmeng Lin, Hu, Hao, Jin Geng, Geng, Jin, Xu, Jiankun, Xing, Qi, Lin, Shanmeng   +9 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

The synthesis and chemistry of model compounds related to fluoropolybcers [PDF]

, 1988
The objectives of this research project were to synthesize and investigate the chemistry of model compounds related to the hexafluoropropene/vinylidene fluoride copolymer system.
Apsey, Glenn C.
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Precision synthesis of macrocyclic giant surfactants tethered with two different polyhedral oligomeric silsesquioxanes at distinct ring locations via four consecutive "click" reactions

, 2015
The combined utilization of chemoselective "click" chemistry allows for the preparation of well-defined macromolecules with complex compositions and architectures.
Zhang, Zhengbiao, Feng, Xueyan, Zhang, Wen-Bin, Lin, Zhiwei, Cheng, Stephen Z. D., Su, Hao, Wang, Zhao, Fu, Qiang, Yue, Kan, Li, Yiwen, Zhu, Xiulin   +10 more
core   +1 more source

A Machine-Learning Framework for Biodegradation Prediction in Sustainable Polymer Systems

Journal of Applied Research in Technology & Engineering
Biodegradable polymers are increasingly central to sustainability-driven materials design, yet predictive modelling of their degradation behaviour across chemically diverse systems remains limited.
Aswin Karkadakattil
doaj   +1 more source

Dynamic covalent chemistry in polymer networks: a mechanistic perspective

Polymer Chemistry, 2019
A selection of dynamic chemistries is highlighted, with a focus on the reaction mechanisms of molecular network rearrangements, and on how mechanistic profiles can be related to the mechanical and physicochemical properties of polymer materials.
Johan M. Winne, L. Leibler, F. D. Du Prez   +2 more
semanticscholar   +1 more source

End-Group Chemistry and Junction Chemistry in Polymer Science: Past, Present, and Future

, 2020
The current goal in functional polymeric material research is the preparation of polymers with high-fidelity nanoscale self-assembled structures and advanced functionality.
Jihoon Kim, H. Jung, M. Park
semanticscholar   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

POLYMER MODIFIED ASPHALT NANOCOMPOSITES [PDF]

, 2011
Asphalt one of the versatile materials of antique, inspite of its compositional variations and complexities, widely employed in various applications like water proofing, paving etc. Due to the complex physical and chemical nature, Asphalt seldom performs
MARKANDAY SUBRAMANIAN, SURESHKUMAR
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