Results 91 to 100 of about 6,325,712 (326)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Structure of laponite-styrene precursor dispersions for production of advanced polymer-clay nanocomposites [PDF]

, 2011
One method for production of polymer-clay nanocomposites involves dispersal of surface-modified clay in a polymerisable monomeric solvent, followed by fast in situ polymerisation.
Liggat, John, Pethrick, Richard, M. B. Sweatman, Sweatman, Martin, R. Fartaria, Javid, Nadeem, R. A. Pethrick, Fartaria, Rui, Sefcik, Jan, J. Sefcik, N. Javid, J. J. Liggat   +11 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Rapid and versatile polymer-polymer coupling via iodide-thiol substitution click chemistry

A rapid and efficient coupling of iodide-terminated poly(butyl acrylate) (PBA-I) chains using a dithiol linker (HS-R-SH) to generate a coupling product (polymer-R-polymer) was developed. The coupling yield reached as high as 86% in 1 min and the coupling
Zhang, Jirui, Goto, Atsushi
core   +1 more source

Heterocycle-based dynamic covalent chemistry for dynamic functional materials

Nature Communications
Dynamic covalent chemistry, which renders reusable and degradable thermoset polymers, is a promising tool for solving the global problem of plastic pollution.
Zeyu Ma, Siyu Pan, Yang Yang, Yuan Zeng, Bo Wang, Yen Wei, Lei Tao   +6 more
doaj   +1 more source

Development, Processing and Applications of a UV-Curable Polymer with Surface Active Thiol Groups

Nanomaterials, 2020
We present here a novel resist formulation with active thiol groups at the surface. The material is UV curable, and can be patterned at the micro- and nanoscale by UV nanoimprint lithography. The resist formulation development, its processing, patterning
Manuel Müller, Rukan Nasri, Lars Tiemann, Irene Fernandez-Cuesta   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Thiol-Michael "click" chemistry: another efficient tool for head functionalization of giant surfactants

, 2014
One of the challenges in the precise synthesis of giant surfactants lies in the homogenous functionalization of a head with bulky ligands. In this article, we report the use of thiol-Michael "click" chemistry as a facile, modular and robust ...
Feng, Xueyan, Wesdemiotis, Chrys, Zhang, Wen-Bin, Cheng, Stephen Z. D., Su, Hao, Wang, Zhao, Guo, Kai, Fu, Qiang, Li, Yiwen   +8 more
core   +1 more source

Nanomechanics of confined polymer systems [PDF]

, 2014
Polymers anchored to surfaces play an important role in nature and technology, and regulate diverse interfacial phenomena in areas such as tribology and colloidal stability.
Hyötylä, Janne T.
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source