Results 71 to 80 of about 6,325,712 (326)

Tailoring the structure of polymer networks with iniferter-mediated photo-growth [PDF]

, 2016
Using dissipative particle dynamics (DPD), we developed a computational approach to capture the photo-controlled radical polymerization (“photo-growth”) of polymer gels containing trithiocarbonate (TTC) groups within the network strands. Using this model,
Balazs, Anna C., Kuksenok, Olga, Johnson, Jeremiah A., Singh, Awaneesh   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Design and Synthesis of a Cyclic Double-Grafted Polymer Using Active Ester Chemistry and Click Chemistry via A “Grafting onto” Method

, 2019
Combing active ester chemistry and click chemistry, a cyclic double-grafted polymer was successfully demonstrated via a “grafting onto” method.
Wei Zhang, Xiulin Zhu, Lu Yin, Shuangshuang Zhang, Meng Liu, Zhengbiao Zhang   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Editing of Polymer Backbones [PDF]

, 2022
Polymers are at the epicenter of modern technological progress and ensuing environmental pollution. Considerations of both polymer functionality and lifecycle are crucial in these contexts, and the polymer backbone—the core of a polymer—is at the root of
Aleksandr, Zhukhovitskiy, Sydney, Towell, Andrew, King, Maxim, Ratushnyy, Rachael, Ditzler   +4 more
core   +1 more source

Types of Crosslinkers and Their Applications in Biomaterials and Biomembranes

Chemistry
Biomaterials and biomembranes play a crucial role in a variety of applications, particularly in the medical field due to their ability to mimic natural biological structures and functions.
Paolo Yammine, Ali El Safadi, Rima Kassab, Hanna El-Nakat, Pierre J. Obeid, Zeina Nasr, Tony Tannous, Nouha Sari-Chmayssem, Agapy Mansour, Ayman Chmayssem   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Recent Developments in Functional Polymers via the Kabachnik–Fields Reaction: The State of the Art

Molecules
Recently, multicomponent reactions (MCRs) have attracted much attention in polymer synthesis. As one of the most well-known MCRs, the Kabachnik–Fields (KF) reaction has been widely used in the development of new functional polymers.
Rui Yuan, Xianzhe He, Chongyu Zhu, Lei Tao   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source