Results 71 to 80 of about 775,763 (359)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Biomedicals from Bone [PDF]

, 2008
The realm of biomaterials, under which biomedical materials can be categorised, has a broad definition base and recognises materials that are synthesized or naturally sourced.
Mucalo, Michael R., Worth, Andrew J.
core  

Investigation of the influence of polyelectrolytes hydrodynamic properties on the hydrate formation process [PDF]

, 2018
One of the most perspective non-traditional sources of hydrocarbon raw materials and energy is gas hydrates (GH), which stimulates their large-scale study in many laboratories and scientific centers around the world.
Bondarenko, Volodymyr, Klymenko, Vasyl, Sai, Kateryna, Svietkina, Olena, Бондаренко, В. И., Бондаренко, В. І., Бондаренко, Владимир Ильич, Бондаренко, Володимир Ілліч, Сай, Е. С., Сай, Екатерина, Сай, К. С., Сай, Катерина   +11 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Bifunctional and recyclable polyesters by chemoselective ring-opening polymerization of a δ-lactone derived from CO2 and butadiene

Nature Communications
When aiming at the direct use of CO2 for the preparation of advanced/value-added materials, the synthesis of CO2/olefin copolymers is very appealing but challenging.
Jinbo Zhang, Lihang Jiang, Shaofeng Liu, Junhao Shen, Pierre Braunstein, Yong Shen, Xiaohui Kang, Zhibo Li   +7 more
doaj   +1 more source

Interfacial Synthesis of a Monolayered Fluorescent Two‐Dimensional Polymer through Dynamic Imine Chemistry

ChemistryOpen, 2020
A fluorescent monolayered two‐dimensional polymer (2DP) containing both tetraphenylethylene (TPE) and imine linkages is synthesized at air‐water interface using the Langmuir‐Blodgett method.
Zhaohui Zhang, Hui Liu, Qingzhu Sun, Feng Shao, Qingyan Pan, Prof. Tao Zhuang, Prof. Yingjie Zhao   +6 more
doaj   +1 more source

Simultaneous Cryogenic Radical and Oxidative Coupling Polymerizations to Polyaniline/Polyacrylamide Conductive Cryogels for Gas Sensing

Gels, 2022
The macro-porous structure of polymer cryogels provides an appropriate channel for the adsorption and transport of substances, endowing its application in the field of electrochemical sensing.
Xiao-Xiao Guo, Shi-Chang Hou, Hui-Juan Li, Jun Chen, Abdul Haleem, Wei-Dong He   +5 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Biometallic peptide-drug conjugates in photo-crosslinkable hydrogels enable combined photothermal-chemotherapy against breast cancer

Journal of Nanobiotechnology
Peptide–drug conjugates (PDCs) offer a powerful therapeutic modality by integrating the targeting specificity of peptides with the cytotoxic efficacy of chemotherapeutics, thereby improving antitumor performance while reducing off-target toxicity.
Rongqiu Mu, Guanghui Gu, Xinyue Wang, Ranran Wang, Gang Wei   +4 more
doaj   +1 more source

Cellulosic materials as biopolymers and supercritical CO2as a green process: chemistry and applications [PDF]

, 2012
In this review, we describe the use of supercritical CO2 (scCO2) in several cellulose applications. The focus is on different technologies that either exist or are expected to emerge in the near future.
Camy, Séverine, Condoret, Jean-Stéphane, Medina-Gonzalez, Yaocihuatl   +2 more
core   +3 more sources