Results 101 to 110 of about 2,178,231 (341)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Polymerization and editing modes of a high-fidelity DNA polymerase are linked by a well-defined path [PDF]

, 2020
Thomas Dodd, Margherita Botto, Fabian Paul, Rafael Fernández-Leiro, Meindert H. Lamers, Ivaylo Ivanov   +5 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

Viruses, 2015
The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication.
Olivier Reynard, Xuan-Nhi Nguyen, Nathalie Alazard-Dany, Véronique Barateau, Andrea Cimarelli, Viktor E. Volchkov   +5 more
doaj   +1 more source

The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography [PDF]

, 2000
Sporulation in Bacillus involves the induction of scores of genes in a temporally and spatially co-ordinated programme of cell development. Its initiation is under the control of an expanded two-component signal transduction system termed a phosphorelay.
Baldus J.M., Brown D.P., Buckner C.M., Buckner C.M., Busby S., Chung J.D., Cowtan K., Ferrari F.A., Fogh R.H., Green B.D., Grimsley J.K., Hatt J.K., Igarashi K., Ireton K., Kenney T.J., Kondo H., Kuldell N., Makino K., Martinez-Hackert E., Muchova K., Murshudov G.N., Olmedo G., Perego M., Satola S.W., Schyns G., Spiegelman G.B., Spiegelman G.B., Strauch M.A., Strauch M.A., Terwilliger T.C., Weir J., Wu H.-M., York K.   +32 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

Cell Reports, 2016
Cancer cells rely on the activation of telomerase or the alternative lengthening of telomeres (ALT) pathways for telomere maintenance and survival. ALT involves homologous recombination (HR)-dependent exchange and/or HR-associated synthesis of telomeric ...
Laura Garcia-Exposito, Elodie Bournique, Valérie Bergoglio, Arindam Bose, Jonathan Barroso-Gonzalez, Sufang Zhang, Justin L. Roncaioli, Marietta Lee, Callen T. Wallace, Simon C. Watkins, Patricia L. Opresko, Jean-Sébastien Hoffmann, Roderick J. O’Sullivan   +12 more
doaj   +1 more source

Entropy involved in fidelity of DNA replication [PDF]

, 2012
Information has an entropic character which can be analyzed within the Statistical Theory in molecular systems. R. Landauer and C.H. Bennett showed that a logical copy can be carried out in the limit of no dissipation if the computation is performed ...
Gonzalo G. de Polavieja, J. Ricardo Arias-Gonzalez   +1 more
core   +4 more sources

Identification of mitochondrial RNA polymerase as a potential therapeutic target of osteosarcoma [PDF]

, 2021
Qicai Han, Xiang-Yang Zhang, Penghui Yan, Songfeng Chen, Feifei Liu, Yun-Rong Zhu, Qing Tian   +6 more
openalex   +1 more source