Results 101 to 110 of about 2,616,862 (309)

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

open access: yesProceedings of the Japan Academy. Series B, Physical and biological sciences, 2017
Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses.
Y. Furuta, T. Komeno, Takaaki Nakamura
semanticscholar   +1 more source

RNA polymerase interactions and elongation rate

open access: yes, 2018
We show that non-steric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track determine strongly the kinetics of transcription elongation.
Belitsky, V., Schütz, G. M.
core   +1 more source

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins [PDF]

open access: yes, 2014
PrimPol is a recently identified polymerase involved in eukaryotic DNA damage tolerance, employed in both re-priming and translesion synthesis mechanisms to bypass nuclear and mitochondrial DNA lesions.
Aaron Ehlinger   +55 more
core   +1 more source

Analysis of the Essential Functions of the C-terminal Protein/Protein Interaction Domain of Saccharomyces cerevisiae pol epsilon and Its Unexpected Ability to Support Growth in the Absence of the DNA Polymerase Domain [PDF]

open access: yes, 1999
As first observed by Wittenberg (Kesti, T., Flick, K., Keranen, S., Syvaoja, J. E., and Wittenburg, C. (1999) Mol. Cell 3, 679-685), we find that deletion mutants lacking the entire N-terminal DNA polymerase domain of yeast pol epsilon are viable ...
Campbell, Judith L.   +2 more
core  

Hamster leukemia virus: lack of endogenous DNA synthesis and unique structure of its DNA polymerase [PDF]

open access: yes, 1974
Infectious hamster leukemia virus (HaLV) contains a DNA polymerase different from those of murine and avian viruses. No endogenous reaction directed by the 60 to 70S RNA of HaLV could be demonstrated in detergenttreated HaLV virions, nor could the ...
Baltimore, David   +3 more
core  

A model for transition of 5 '-nuclease domain of DNA polymerase I from inert to active modes [PDF]

open access: yes, 2011
Bacteria contain DNA polymerase I (PolI), a single polypeptide chain consisting of similar to 930 residues, possessing DNA-dependent DNA polymerase, 3'-5' proofreading and 5'-3' exonuclease (also known as flap endonuclease) activities.
A Díaz   +50 more
core   +4 more sources

Bioplastics and food packaging: A review

open access: yesCogent Food & Agriculture, 2015
Food packaging as a vital part of the subject of food technology is involved with protection and preservation of all types of foods. Due to economical abundance, petrochemical plastics have been largely used as packaging material due to their desirable ...
Nafisa Jabeen   +2 more
doaj   +1 more source

Theoretical analysis of transcription process with polymerase stalling [PDF]

open access: yesarXiv, 2015
Experimental evidences show that in gene transcription, RNA polymerase has the possibility to be stalled at certain position of the transcription template. This may be due to the template damage, or protein barriers. Once stalled, polymerase may backtrack along the template to the previous nucleotide to wait for the repair of the damaged site, or ...
arxiv  

An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family [PDF]

open access: yes, 2014
A mutant of the high fidelity family-B DNA polymerase from the archaeon Thermococcus gorgonarius (Tgo-Pol), able to replicate past DNA lesions, is described.
Aidan J. Doherty   +68 more
core   +1 more source

How the Avidity of Polymerase Binding to the -35/-10 Promoter Sites Affects Gene Expression [PDF]

open access: yes, 2019
Although the key promoter elements necessary to drive transcription in Escherichia coli have long been understood, we still cannot predict the behavior of arbitrary novel promoters, hampering our ability to characterize the myriad of sequenced regulatory architectures as well as to design novel synthetic circuits.
arxiv   +1 more source

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