Results 121 to 130 of about 2,616,862 (309)

Proficient replication of the yeast genome by a viral DNA polymerase [PDF]

, 2016
DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ϵ. Pol δ replicates and matures Okazaki fragments on the lagging strand of the replication fork.
Burgers, Peter M, Stith, Carrie M, Stodola, Joseph L   +2 more
core   +2 more sources

DNA Polymerase ε: A Polymerase of Unusual Size (and Complexity) [PDF]

, 2008
Publisher Summary DNA polymerase epsilon (Pol epsilon) is a large, multi-subunit polymerase that is conserved throughout all eukaryotes. In addition to its role as one of the three DNA polymerases responsible for bulk chromosomal replication, Pol epsilon is implicated in a wide variety of important cellular processes, including the repair of damaged ...
Thomas A. Kunkel, Zachary F. Pursell
openaire   +3 more sources

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

Nature Microbiology, 2018
The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria1. For decades, it was thought that only class A penicillin-binding proteins (PBPs) and related enzymes effected peptidoglycan synthesis.
A. Taguchi, Michael A. Welsh, L. S. Marmont, Wonsik Lee, M. Sjodt, A. Kruse, D. Kahne, T. Bernhardt, S. Walker   +8 more
semanticscholar   +1 more source

P53 tumour-suppressor gene mutations are mainly localised on exon 7 in human primary and metastatic prostate cancer. [PDF]

, 1996
Mutations in the p53 tumour-suppressor gene are among the most common genetic alterations in human cancers. In the present study we analysed the mutations in the p53 tumor-suppressor gene in 25 primary and 20 metastatic human prostate cancer specimens ...
Chen, KM, Chui, RM, Dahiya, R, Deng, G, Haughney, PC, Narayan, P   +5 more
core   +2 more sources

Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

Molecules, 2020
In the last three decades, oligonucleotides have been extensively investigated as probes, molecular ligands and even catalysts within therapeutic and diagnostic applications.
Steven Ochoa, Valeria T. Milam
doaj   +1 more source

Influenza virus polymerase inhibitors in clinical development

Current Opinion in Infectious Diseases, 2019
Purpose of review We review antivirals inhibiting subunits of the influenza polymerase complex that are advancing in clinical development. Recent findings Favipiravir, pimodivir, and baloxavir are inhibitory in preclinical models for influenza A viruses,
F. Hayden, N. Shindo
semanticscholar   +1 more source

Dynamics of Molecular Motors and Polymer Translocation with Sequence Heterogeneity [PDF]

, 2004
The effect of sequence heterogeneity on polynucleotide translocation across a pore and on simple models of molecular motors such as helicases, DNA polymerase/exonuclease and RNA polymerase is studied in detail.
Kafri, Yariv, Lubensky, David K., Nelson, David R.   +2 more
core   +2 more sources

Amino acids in the polymerase complex of shorebird-isolated H1N1 influenza virus impact replication and host-virus interactions in mammalian models

Emerging Microbes and Infections
A diverse population of avian influenza A viruses (AIVs) are maintained in wild birds and ducks yet the zoonotic potential of AIVs in these environmental reservoirs and the host-virus interactions involved in mammalian infection are not well understood ...
Yaqin Bai, Hui Lei, Wenjun Song, Sang-Chul Shin, Jiaqi Wang, Biying Xiao, Zeynep A. Koçer, Min-Suk Song, Robert Webster, Richard J. Webby, Sook-San Wong, Mark Zanin   +11 more
doaj   +1 more source

A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity

Viruses, 2020
Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years.
Andrew Cox, Jordana Schmierer, Josephine D’Angelo, Andrew Smith, Dustyn Levenson, John Treanor, Baek Kim, Stephen Dewhurst   +7 more
doaj   +1 more source

DNA polymerase V activity is autoregulated by a novel intrinsic DNA-dependent ATPase [PDF]

arXiv, 2014
Escherichia coli DNA polymerase V (pol V), a heterotrimeric complex composed of UmuD'2C, is marginally active. ATP and RecA play essential roles in the activation of pol V for DNA synthesis including translesion synthesis (TLS). We have established three features of the roles of ATP and RecA.
arxiv