Results 181 to 190 of about 1,254,897 (274)

A Novel 3D High‐Throughput Phenotypic Drug Screening Pipeline to Identify Drugs with Repurposing Potential for the Treatment of Ovarian Cancer

Advanced Healthcare Materials, EarlyView.
Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia, Amy L. Wilson, Brittany R. Doran, Jennie Do, Amelia Matthews, Gwo Y. Ho, Magdalena Plebanski, Thomas W. Jobling, Andrew N. Stephens, Maree Bilandzic   +9 more
wiley   +1 more source

Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin. [PDF]

Nat Plants
Li J, Cao L, Zhao Y, Shen J, Wang L, Feng M, Zhu M, Ye Y, Kormelink R, Tao X, Wang X.   +10 more
europepmc   +1 more source

Polynucleotide Celluloses as Solid State Primers and Templates for Polymerases

, 1968
Thomas M. Jovin, Arthur Kornberg
openalex   +1 more source

Characterization of the ribonucleic acid product synthesized by an influenza A2 virus-induced ribonucleic acid polymerase in vitro [PDF]

, 1968
M.G. Page, B. J. Ruck, K. W. Brammer
openalex   +1 more source

TPMS‐Gyroid Scaffold‐Mediated Up‐Regulation of ITGB1 for Enhanced Cell Adhesion and Immune‐Modulatory Osteogenesis

Advanced Healthcare Materials, EarlyView.
A) SLM generates biomimetic bone scaffolds with consistent porosity but varying TPMS‐Gyroid unit cell designs (TG15, TG20, TG25, TG30). B) By enhancing the expression of ITGB1, TPMS‐Gyroid scaffolds can facilitate osteogenic differentiation in BMSCs and promote M2 polarization in macrophages.
Jing Wang, Zenan Huang, Zhenzhong Han, Jing Luan, Zihan Li, Xutong Guo, Dongxu Yang, Yazhou Cui, Jinxiang Han, Duo Xu   +9 more
wiley   +1 more source

A robust strategy for overexpression of DNA polymerase from Thermus aquaticus using an IPTG-independent autoinduction system in a benchtop bioreactor. [PDF]

Sci Rep
Laksmi FA, Lischer K, Nugraha Y, Violando WA, Helbert, Nuryana I, Khasna FN, Nur N, Ramadhan KP, Tobing DAL, Hariyatun, Hidayat I.   +11 more
europepmc   +1 more source

Studies on Deoxyribonucleic Acid Polymerase from Ehrlich Ascites Tumor Cells

, 1969
Ranajit Roychoudhury, David P. Bloch
openalex   +1 more source

THE FINE STRUCTURE OF THE GENE CONTROLLING THE SYNTHESIS OF DNA POLYMERASE IN BACTERIOPHAGE T4B [PDF]

, 1969
S. I. Alikhanian, V.Z. Pogosov
openalex   +1 more source

A Dual‐Layer Hydrogel Barrier Integrating Bio‐Adhesive and Anti‐Adhesive Properties Prevents Postoperative Abdominal Adhesions

Advanced Healthcare Materials, EarlyView.
A new dual‐layer hydrogel barrier for preventing postoperative abdominal adhesions is developed. The inner layer, consisting of polyethyleneimine (PEI) and thioctic acid (TA), enhanced adhesion to moist tissues. The outer layer combines zwitterionic, thermoresponsive hyaluronic acid with anti‐inflammatory epigallocatechin gallate (EGCG) and forms a ...
Mena Asha Krishnan, Olawale A. Alimi, Mitchell Kuss, Tiffany N Razabdouski, Erika A Eksioglu, Bin Duan, Bo Liu   +6 more
wiley   +1 more source

<i>In silico</i> evaluation of snake venom proteins against multidrug-resistant <i>Mycobacterium tuberculosis</i>: A molecular dynamics study and simulation dynamic. [PDF]

Open Vet J
Fouda M, Mantargi MJS, Germoush MO, Sarhan M, Husein MF, Abdel-Daim MM.   +5 more
europepmc   +1 more source