Results 31 to 40 of about 1,280,950 (298)
Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication
Viruses, 2022 The COVID-19 pandemic continues to threaten healthcare systems worldwide due to the limited access to vaccines, suboptimal treatment options, and the continuous emergence of new and more transmissible SARS-CoV-2 variants.
Ulrik Fahnøe +11 more
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Cell, 1999 The appearance of these structures represents a historic advance in our understanding of one of molecular biology's most remarkable enzymes. Here we have suggested several possible structural bases for key steps in its function. Although speculative, they should serve as stimuli for future work.
Robert Landick, Rachel A. Mooney
openaire +3 more sources
Biophysical Chemistry, 2011 Molecular motors can exhibit Brownian ratchet or power stroke mechanisms. These mechanistic categories are related to transition state position: An early transition state suggests that chemical energy is stored and then released during the step (stroke) while a late transition state suggests that the release of chemical energy rectifies thermally ...
Eric A. Galburt +2 more
openaire +4 more sources
A Comprehensive Superposition of Viral Polymerase Structures
Viruses, 2019 Nucleic acid polymerases are essential enzymes that replicate the genomes of both RNA and DNA viruses. These enzymes are generally encoded by viruses themselves so as to provide biochemical functions and control elements that differ from those of the ...
Olve B. Peersen
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Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides
Molecules, 2020 In the last three decades, oligonucleotides have been extensively investigated as probes, molecular ligands and even catalysts within therapeutic and diagnostic applications.
Steven Ochoa, Valeria T. Milam
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Directed evolution of novel polymerase activities: Mutation of a DNA polymerase into an efficient RNA polymerase [PDF]
Proceedings of the National Academy of Sciences, 2002 The creation of novel enzymatic function is of great interest, but remains a challenge because of the large sequence space of proteins. We have developed an activity-based selection method to evolve DNA polymerases with RNA polymerase activity.
Takashi Sera +5 more
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Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Viruses, 2020 Current influenza vaccines have modest efficacy. This is especially true for current live attenuated influenza vaccines (LAIV), which have been inferior to the inactivated versions in recent years.
Andrew Cox +7 more
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Norovirus Proteinase-Polymerase and Polymerase Are Both Active Forms of RNA-Dependent RNA Polymerase [PDF]
Journal of Virology, 2005 ABSTRACT In vitro mapping studies of the MD145 norovirus ( Caliciviridae ) ORF1 polyprotein identified two stable cleavage products containing the viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature polymerase).
Gaël Belliot +7 more
openaire +3 more sources
FEBS Letters, EarlyView.Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke +2 more
wiley +1 more source