Results 31 to 40 of about 1,813,709 (344)

Structure of replicating SARS-CoV-2 polymerase

open access: yesNature, 2020
The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes1–3.
H. S. Hillen   +5 more
semanticscholar   +1 more source

Polymerase Chain Reaction [PDF]

open access: yesJournal of Investigative Dermatology, 2013
The advent of the polymerase chain reaction (PCR) radically transformed biological science from the time it was first discovered (Mullis, 1990). For the first time, it allowed for specific detection and production of large amounts of DNA. PCR-based strategies have propelled huge scientific endeavors such as the Human Genome Project.
Nidhi Avashia, Lilit Garibyan
openaire   +2 more sources

The Functional Implications of Broad Spectrum Bioactive Compounds Targeting RNA-Dependent RNA Polymerase (RdRp) in the Context of the COVID-19 Pandemic

open access: yesViruses, 2023
Background: As long as COVID-19 endures, viral surface proteins will keep changing and new viral strains will emerge, rendering prior vaccines and treatments decreasingly effective.
Brittany A. Comunale   +5 more
doaj   +1 more source

RNA Polymerase Unveiled [PDF]

open access: yesCell, 1999
The appearance of these structures represents a historic advance in our understanding of one of molecular biology's most remarkable enzymes. Here we have suggested several possible structural bases for key steps in its function. Although speculative, they should serve as stimuli for future work.
Robert Landick, Rachel A. Mooney
openaire   +3 more sources

Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities

open access: yesViruses, 2023
The human respiratory syncytial virus (RSV) is a negative-sense, single-stranded RNA virus. It is the major cause of severe acute lower respiratory tract infection in infants, the elderly population, and immunocompromised individuals.
Priscila Sutto-Ortiz   +3 more
doaj   +1 more source

The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses

open access: yesViruses, 2020
The Eurasian avian-like swine (EA) H1N1 virus has affected the Chinese swine industry, and human infection cases have been reported occasionally. However, little is known about the pathogenic mechanism of EA H1N1 virus.
Mengkai Cai   +10 more
doaj   +1 more source

RNA polymerase pushing [PDF]

open access: yesBiophysical Chemistry, 2011
Molecular motors can exhibit Brownian ratchet or power stroke mechanisms. These mechanistic categories are related to transition state position: An early transition state suggests that chemical energy is stored and then released during the step (stroke) while a late transition state suggests that the release of chemical energy rectifies thermally ...
Eric A. Galburt   +2 more
openaire   +4 more sources

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

open access: yesViruses, 2015
The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication.
Olivier Reynard   +5 more
doaj   +1 more source

Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export

open access: yesFrontiers in Microbiology, 2019
The influenza A virus replicates in a broad range of avian and mammalian species by hijacking cellular factors and processes. Avian influenza A viruses (AIVs) generally propagated poorly in mammalian cells, but some mutants of virus-encoded RNA ...
Xingxing Ren   +23 more
doaj   +1 more source

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

open access: yesNew England Journal of Medicine, 2009
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific DNA-repair defects, including those arising in carriers of a BRCA1 or ...
P. Fong   +14 more
semanticscholar   +1 more source

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