Results 41 to 50 of about 2,158,859 (241)
Cell, 1999 The appearance of these structures represents a historic advance in our understanding of one of molecular biology's most remarkable enzymes. Here we have suggested several possible structural bases for key steps in its function. Although speculative, they should serve as stimuli for future work.
Robert Landick, Rachel A. Mooney
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P53 tumour-suppressor gene mutations are mainly localised on exon 7 in human primary and metastatic prostate cancer. [PDF]
, 1996 Mutations in the p53 tumour-suppressor gene are among the most common genetic alterations in human cancers. In the present study we analysed the mutations in the p53 tumor-suppressor gene in 25 primary and 20 metastatic human prostate cancer specimens ...
Chen, KM +5 more
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Biophysical Chemistry, 2011 Molecular motors can exhibit Brownian ratchet or power stroke mechanisms. These mechanistic categories are related to transition state position: An early transition state suggests that chemical energy is stored and then released during the step (stroke) while a late transition state suggests that the release of chemical energy rectifies thermally ...
Eric A. Galburt +2 more
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Brazilian Archives of Biology and Technology, 2010 The nuclear ribosomal DNA internal transcribed spacers (ITS1 and ITS2) from leaves of Drosera (Droseraceae) were amplified using "universal" primers.
Vitor Fernandes Oliveira de Miranda +3 more
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Cell Reports, 2020 Summary: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge number of human deaths. Currently, there are no specific drugs or vaccines available for this virus (SARS-CoV-2).
Qi Peng +11 more
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Viruses, 2016 Rabbit haemorrhagic disease virus (RHDV) is a calicivirus that causes acute infections in both domestic and wild European rabbits (Oryctolagus cuniculus). The virus causes significant economic losses in rabbit farming and reduces wild rabbit populations.
Nadya Urakova +5 more
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Translesion synthesis in mammalian cells [PDF]
, 2006 DNA damage blocks the progression of the replication fork. In order to circumvent the damaged bases, cells employ specialized low stringency DNA polymerases, which are able to carry out translesion synthesis (TLS) past different types of damage. The five
Alan R. Lehmann +35 more
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Directed evolution of novel polymerase activities: Mutation of a DNA polymerase into an efficient RNA polymerase [PDF]
Proceedings of the National Academy of Sciences, 2002 The creation of novel enzymatic function is of great interest, but remains a challenge because of the large sequence space of proteins. We have developed an activity-based selection method to evolve DNA polymerases with RNA polymerase activity.
Takashi Sera +5 more
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Norovirus Proteinase-Polymerase and Polymerase Are Both Active Forms of RNA-Dependent RNA Polymerase [PDF]
Journal of Virology, 2005 ABSTRACT In vitro mapping studies of the MD145 norovirus ( Caliciviridae ) ORF1 polyprotein identified two stable cleavage products containing the viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature polymerase).
Gaël Belliot +7 more
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Microbiology SpectrumThe H5N6 avian influenza virus, a highly pathogenic strain, poses a significant threat to poultry production and public health. The RNA-dependent RNA polymerase (comprising PB1, PB2, and PA proteins) and nucleoprotein of highly pathogenic avian influenza
Lei Cao +10 more
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