Results 71 to 80 of about 2,178,231 (341)
Translesion synthesis: Y-family polymerases and the polymerase switch
DNA Repair, 2007 Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage.
Lehmann Alan R +7 more
openaire +2 more sources
FEBS Letters, EarlyView.PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley +1 more source
eDNA Replicates, Polymerase and Amplicon Size Impact Inference of Richness Across Habitats
Environmental DNAEnvironmental DNA‐based monitoring has been increasingly used in the last decade to monitor biodiversity in aquatic and terrestrial systems. Molecular‐based surveys now allow quick and reliable production of baseline knowledge of species community ...
Jarl Andreas Anmarkrud +7 more
doaj +1 more source
Вавиловский журнал генетики и селекции, 2020 Noroviruses (the Caliciviridae family) are a common cause of acute gastroenteritis in all age groups. These small non-envelope viruses with a single-stranded (+)RNA genome are characterized by high genetic variability.
E. V. Zhirakovskaia +5 more
doaj +1 more source
A global function for transcription factors in assisting RNA polymerase II termination. [PDF]
, 2017 The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
core +1 more source
DNA Polymerase ε: A Polymerase of Unusual Size (and Complexity) [PDF]
, 2008 Publisher Summary DNA polymerase epsilon (Pol epsilon) is a large, multi-subunit polymerase that is conserved throughout all eukaryotes. In addition to its role as one of the three DNA polymerases responsible for bulk chromosomal replication, Pol epsilon is implicated in a wide variety of important cellular processes, including the repair of damaged ...
Zachary F, Pursell, Thomas A, Kunkel
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3
Frontiers in Immunology, 2017 The influenza A virus (IAV) can be recognized by retinoic acid-inducible gene I (RIG-I) to activate the type I interferon response and induce antiviral effects.
Chenyang Yi +31 more
doaj +1 more source
DNA Polymerase Profiling [PDF]
, 2008 We report a simple homogeneous fluorescence assay for quantification of DNA polymerase function in high throughput. The fluorescence signal is generated by the DNA polymerase triggering opening of a molecular beacon extension of the template strand. A resulting distance alteration is reported by fluorescence resonance energy transfer between two dyes ...
openaire +3 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source