Results 251 to 260 of about 1,398,764 (327)

METTL14‐Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex

Advanced Science, EarlyView.
METTL14/IGF2BP2‐mediated m6A modification drives LINC01094 upregulation in BC. Then, LINC01094 interacts with PKM2 monomers to promote their dimerization, while serving as a flexible scaffold to facilitate the assembly of the PKM2/JMJD5 complex, synergistically stabilizing PKM2 dimers and enhancing their nuclear translocation.
Mengqi Wang, Zhaoxin Gao, Ruinan Zhao, Pan Zhou, Jingxi Chen, Hui Zhang, Yawen Wang, Wenjie Zhu, Peng Gao   +8 more
wiley   +1 more source

Development of a Multiplex Quantitative Polymerase Chain Reaction Assay for the Detection of Duck Enteritis Virus, Goose Parvovirus, and Muscovy Duck Parvovirus. [PDF]

Animals (Basel)
Qiu Q, Hu R, Liu Z, Yan L, Yang F, Dai X, Xing C, Cao H.   +7 more
europepmc   +1 more source

Use of group-specific primers and the polymerase chain reaction for the detection and identification of luteoviruses

, 1991
N. L. Robertson, R. French, Stewart M. Gray   +2 more
openalex   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

Evaluation of Conventional Polymerase Chain Reaction for Accurate Species Identification of Elizabethkingia Compared to Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. [PDF]

Cureus
Mahapatra S, Mahapatra A, Sarathi S, Behera B, Mohapatra S.   +4 more
europepmc   +1 more source

Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.

, 1991
Stephen J. Meltzer, Jie Yin, Ying Huang, T K McDaniel, Carnell Newkirk, Oscar A. Iseri, Bert Vogelstein, James H. Resau   +7 more
openalex   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

Detection of sexually transmitted infection agents in pregnant women using multiplex polymerase chain reaction method. [PDF]

BMC Pregnancy Childbirth
Bakir A, Cendek BD, Usluca S, Aral M, Korkut G, Morkoc M, Yagiz GC, Kurkcu MF, Sapmaz MA, Polat M, Erbey S, Ozturk BG, Keskin HL.   +12 more
europepmc   +1 more source

A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction.

, 1990
Takashi Kadowaki, Hiroaki Kadowaki, Simeon I. Taylor   +2 more
openalex   +1 more source

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD

Advanced Science, EarlyView.
TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang, Qi Wang, Dongkun Kang, Shijia Wang, Yanli Jiang, Jian‐Zhi Wang, Chen Ming, Rong Liu, Jianlan Gu, Xiaochuan Wang   +9 more
wiley   +1 more source