Results 231 to 240 of about 1,424,412 (299)

Detection of streptococcal deoxyribonucleic acid with polymerase chain reaction in excised valvular tissue of rheumatic heart disease patients. [PDF]

Ann Pediatr Cardiol
Parashar NK, Mantoo MR, Arava S, Ramakrishnan S, Rajashekar P, Sinha M, Seth S, Bhargava B.   +7 more
europepmc   +1 more source

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Prevalence of herpes simplex virus 1 and 2 in culture-negative suppurative keratitis using polymerase chain reaction - A pilot study. [PDF]

Indian J Ophthalmol
Rajasekaran NM, Krishna TS, Amritanand A, Korah S, Abraham AM, Mammen S, Michael J, Ramadoss B, Samuel P, Kuriakose T, Paul P.   +10 more
europepmc   +1 more source

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Multiplex Polymerase Chain Reaction Panels for Gastrointestinal Infections: Current Evidence, Regulatory Hurdles, and the Way Forward. [PDF]

Open Forum Infect Dis
Tansarli GS, Allen DR, Fang FC.
europepmc   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Comparison of Real-Time Polymerase Chain Reaction and Anaerobic Culture for Detecting and Quantifying Porphyromonas gingivalis in Subgingival Plaque From Periodontitis and Healthy Subjects. [PDF]

Cureus
Rachita T, Kumaraswamy S, Kodati S, Ansari T, Karre S, David A, Tiwari R, Gupta S.   +7 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Comparative Analysis of Viral Load Quantification Using Reverse Transcription Polymerase Chain Reaction and Digital Droplet Polymerase Chain Reaction. [PDF]

Int J Mol Sci
Gebe Abreu Cabral P, Bastos de Souza S, Ferraz Arruda R, Passos de Figueiredo Cabral S, Leone Evangelista Monteiro de Assis A, Porto Muniz Martins Y, Brazil Viana Junior A, Chang J, Lei P, Martins da Silva R.   +9 more
europepmc   +1 more source