Results 1 to 10 of about 236,694 (244)

Isolation of GFP-expressing Malarial Hypnozoites by Flow Cytometry Cell Sorting

Bio-Protocol, 2021
Hypnozoites are dormant liver-stage parasites unique to relapsing malarial species, including the important human pathogen Plasmodium vivax, and pose a barrier to the elimination of malaria.
Annemarie Voorberg-van der Wel, Sam Hofman, Clemens Kocken   +2 more
doaj   +1 more source

FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS [PDF]

Journal of Experimental Medicine, 1914
1. The malarial parasite is extracellular throughout its life cycle and migrates from red corpuscle to red corpuscle destroying each before it abandons it; in the brief intervals between, the parasite is free in the blood serum; it does not remain long free, but almost immediately attaches itself to another red corpuscle by means of delicate ...
openaire   +2 more sources

Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum

Malaria Journal, 2010
Background The efficacy of anti-malarial drugs is determined by the level of parasite susceptibility, anti-malarial drug bioavailability and pharmacokinetics, and host factors including immunity. Host immunity improves the in vivo therapeutic efficacy of
Udomsangpetch Rachanee, Krudsood Srivicha, Dondorp Arjen M, Mungthin Mathirut, Monatrakul Preeyaporn, Wilairatana Polrat, White Nicholas J, Chotivanich Kesinee   +7 more
doaj   +1 more source

Treatment with specific and pan-plasma membrane calcium ATPase (PMCA) inhibitors reduces malaria parasite growth in vitro and in vivo

Malaria Journal, 2022
Background Rapid emergence of Plasmodium resistance to anti-malarial drug mainstays has driven a continual effort to discover novel drugs that target different biochemical pathway (s) during infection.
Puji B. S. Asih, Josephine E. Siregar, Farahana K. Dewayanti, Normalita E. Pravitasari, Ismail E. Rozi, Andita F. M. Rizki, Rifqi Risandi, Kevin N. Couper, Delvac Oceandy, Din Syafruddin   +9 more
doaj   +1 more source

The parasite clearance curve

Malaria Journal, 2011
Parasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance.
White NJ
doaj   +1 more source

Biological activities of nitidine, a potential anti-malarial lead compound

Malaria Journal, 2012
Background Nitidine is thought to be the main active ingredient in several traditional anti-malarial remedies used in different parts of the world. The widespread use of these therapies stresses the importance of studying this molecule in the context of ...
Bouquet Jérome, Rivaud Marion, Chevalley Séverine, Deharo Eric, Jullian Valérie, Valentin Alexis   +5 more
doaj   +1 more source

Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance

Malaria Journal, 2009
Background Preventing the emergence of anti-malarial drug resistance is critical for the success of current malaria elimination efforts. Prevention strategies have focused predominantly on qualitative factors, such as choice of drugs, use of combinations
Lee Sue J, Stepniewska Kasia, Aguas Ricardo, Saralamba Sompob, Maude Richard J, Pongtavornpinyo Wirichada, White Nicholas J, Dondorp Arjen M, White Lisa J, Day Nicholas PJ   +9 more
doaj   +1 more source

The Origin of Malarial Parasites in Orangutans

PLoS ONE, 2012
Recent findings of Plasmodium in African apes have changed our perspectives on the evolution of malarial parasites in hominids. However, phylogenetic analyses of primate malarias are still missing information from Southeast Asian apes. In this study, we report molecular data for a malaria parasite lineage found in orangutans.We screened twenty-four ...
Pacheco, M. Andreína, Reid, Michael J.C., Schillaci, Michael A., Lowenberger, Carl A., Galdikas, Biruté M. F., Jones-Engel, Lisa, Escalante, Ananias A.   +6 more
openaire   +5 more sources

A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score

Malaria Journal, 2023
Background Malaria, a treatable disease mainly caused by Plasmodium falciparum has remained a health challenge in Africa, a continent that accounted for 96% of total global cases and deaths in 2021.
Jimmy R. Angupale, Jonans Tusiimire, Ndidi C. Ngwuluka   +2 more
doaj   +1 more source

Computational investigation on the photoacoustics of malaria infected red blood cells. [PDF]

PLoS ONE, 2012
A computer simulation study on the possibility of using photoacoustic (PA) technique to differentiate intraerythrocytic stages of malarial parasite is reported. This parasite during its development substantially converts hemoglobin into hemozoin.
Ratan K Saha, Subhajit Karmakar, Madhusudan Roy   +2 more
doaj   +1 more source