Results 161 to 170 of about 874,733 (285)

Exploration of miR-326 delivery via biocompatible polymeric nanoparticles in medulloblastoma: A preliminary study. [PDF]

Mol Ther Nucleic Acids
Splendiani E, Maiorano G, Spinello Z, Vecchiotti D, Gugliuzza G, Moretti M, Asquino A, Izzo M, Po A, Feverati N, Raia T, Besharat ZM, Verzella D, Mardente S, Zicari A, Ciccarella G, Citarella A, Zazzeroni F, De Smaele E, Venneri MA, Mastronuzzi A, Gigli G, Angelucci A, Catanzaro G, Palamà IE, Ferretti E.   +25 more
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Bakuchiol-loaded amphiphilic polymeric nanoparticles: enhancing stability and multifunctionality through encapsulation. [PDF]

J Biol Eng
Seo D, Yu S, Kim T, Park J, Kim H, Sung D.   +5 more
europepmc   +1 more source

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (<i>Macaca mulatta</i>). [PDF]

Hum Gene Ther
Piotrowski-Daspit AS, Lynn AY, Eaton DA, Bracaglia LG, Markey AI, Mortlock RD, Stitelman DH, Martinez ML, Lee CC, Kliman HJ, Glazer PM, Tarantal AF, Saltzman WM.   +12 more
europepmc   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

RETRACTED: Mohanty et al. Formulation and Optimization of Alogliptin-Loaded Polymeric Nanoparticles: In Vitro to In Vivo Assessment. <i>Molecules</i> 2022, <i>27</i>, 4470. [PDF]

Molecules
Mohanty D, Gilani SJ, Zafar A, Imam SS, Kumar LA, Ahmed MM, Jahangir MA, Bakshi V, Ahmad W, Eltayib EM.   +9 more
europepmc   +1 more source

Hydrophilic Polymers Enable Gastrointestinal Transit Monitoring by Fluorine‐19 Magnetic Resonance Imaging

Advanced Healthcare Materials, EarlyView.
Hydrophilic fluorinated copolymers dissolve in chyme and give a strong, single 19F signal, unlike phase‐separating perfluorocarbons. Combined 1H‐19F MRI tracks their whole‐gut transit non‐invasively and without ionizing radiation. In rats, the tracers move through the gastrointestinal tract, resist resorption, and are well tolerated, a proof‐of‐concept
Ondřej Groborz, Vít Herynek, Mária Hovořáková, Zuzana Pavlíková, Linda Dalecká, Klára Steklíková, Petr Matouš, Petr Páral, Margarita Tkachenko, Filip Koucký, Fatma Nalan Cetin, Ludmila Maffei Svobodová, Jiří Beneš, Kristýna Kolouchová   +13 more
wiley   +1 more source

Engineered biodegradable polymeric nanoparticles injectable system of atorvastatin for improved therapeutic activity. [PDF]

Sci Rep
Venkatraman R, B Narayanan VH, Nowakowski S, Nellinger S, Kluger P, Kopka B, Brzezinski M, Sankar A, Durai R.   +8 more
europepmc   +1 more source