Results 41 to 50 of about 8,907,599 (231)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Growing Polymer Vesicles Generated by Polymerization Induced Self-Assembly Coupled With a Living Chemical Reactor

Frontiers in Bioengineering and Biotechnology, 2020
Chemical oscillatory reactions have attracted intensive attention due to their autonomous, continuous, and periodic features. Herein, the radicals generated in Belousov-Zhabotinsky (BZ) oscillator was used to initiate RAFT (reversible addition ...
Zhihui Lu, Jinshan Guo
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

Advanced Science
Therapeutic agents usually must reach diseased tissue and then exert biological effects. While numerous targeted and stimuli‐responsive delivery systems have been developed, their therapeutic outcomes have been limited due to the lack of “precision”.
Mian Tang, Junteng Qiu, Yunfeng Lu, Yahui Song, Xinyu Zhou, Tianshun Duan, Xuanqi Peng, Caixia Yin, Cheng Gao, Ruibing Wang   +9 more
doaj   +1 more source

Gradient hydrogels based on photo-initiated polymerization-induced self-assembly

Giant
Gradient materials enable performance optimization by adjusting composition or structure across one or more dimensions while minimizing interfacial incompatibility.
Yingchu Zhou, Ziqi Liu, Yi Zeng, Li Luo, Jie Chen, Diyuan Zheng, Zhao Wu, Chao Lang   +7 more
doaj   +1 more source

) copolymers via polymerization‐induced thermal self‐assembly [PDF]

, 2023
Self‐assembled polymeric nanoparticles have been of great interest for various biological applications such as drug delivery, catalysis, and biosensing.
Kumar, C. M. Santosh; id_orcid, Akar, Irem, Calum Ferguson, Pearce, Amanda K.; id_orcid, Amanda K. Pearce, Irem Akar, C. M. Santosh Kumar, Rachel K. O'Reilly, Ferguson, Calum, O'Reilly, Rachel K.; id_orcid   +9 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

RAFT alcoholic dispersion polymerization with polymerization-induced self-assembly

, 2016
© 2016 Elsevier Ltd. This article reviews the current state of the art with respect to RAFT alcoholic dispersion polymerization processes that proceed with polymerization-induced self-assembly (PISA) and covers the bulk of the literature up to mid-2016 ...
Andrew Lowe (23285590)
core   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source