Results 191 to 200 of about 3,539,255 (350)

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

Nature, 2009
D. Ge, J. Fellay, A. Thompson, J. Simon, K. Shianna, T. Urban, E. Heinzen, P. Qiu, A. Bertelsen, A. Muir, M. Sulkowski, J. Mchutchison, D. Goldstein   +12 more
semanticscholar   +1 more source

Alnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin

Advanced Science, EarlyView.
This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen   +13 more
wiley   +1 more source

Association of the pri-miR-34b/c rs4938723 T > C polymorphism with hepatoblastoma susceptibility in Eastern Chinese children: A five-center case-control study. [PDF]

BMC Med Genomics
Zhang W, Zhu J, Bian J, Zhou C, Zhang S, He S, Lu H, Wang Y, He J.   +8 more
europepmc   +1 more source

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

Advanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang   +11 more
wiley   +1 more source

Investigation of <i>LBX1, TIMP2, GPR126</i> and <i>CHD7</i> Gene Polymorphisms in Adolescent Idiopathic Scoliosis Patients. [PDF]

Global Spine J
Bilgin E, Tezcan Unlu H, Cecener G, Aymelek HS, Bilgin Y, Akesen B.   +5 more
europepmc   +1 more source

Genetic Deconvolution of Embryonic and Maternal Cell‐Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning

Advanced Science, EarlyView.
DECENT is a deep learning method that enhances noninvasive preimplantation genetic testing by accurately reconstructing embryonic copy number variations (CNVs) from cell‐free DNA in spent embryo culture media. By mitigating maternal contamination, DECENT improves diagnostic accuracy, even with high contamination levels, offering a reliable, noninvasive
Zhenyi Zhang, Jie Qiao, Yidong Chen, Peijie Zhou   +3 more
wiley   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

Genetic diversity, population structure and quality-trait associations in Blumea balsamifera revealed by EST-SSR markers. [PDF]

PLoS One
Huang M, Li X, Chen Z, Wang D, Wang K, Hu X, Chen X, Guan L, Zhang H, Pang Y, Yu F.   +10 more
europepmc   +1 more source

De Novo Reconstruction of 3D Human Facial Images from DNA Sequence

Advanced Science, EarlyView.
This study introduces Difface, a novel deep‐learning model for reconstructing 3D facial images only from DNA data. By integrating transformer networks, spiral convolutions, and a diffusion model, Difface directly aligns high‐dimensional SNP data with 3D facial structures.
Mingqi Jiao, Jiarui Li, Bingxu Zhong, Siyuan Du, Shuning Li, Manfei Zhang, Qibin Zhang, Zhongming Liang, Fan Liu, Chunman Zuo, Sijia Wang, Luonan Chen   +11 more
wiley   +1 more source

Psychosocial and genetic determinants of tobacco smoking as an addictive disease [PDF]

Vojnosanitetski Pregled, 2006
Pešut Dragica, Bursuc Bogdana, Ciobanu Laura, Nagorni-Obradović Ljudmila   +3 more
doaj   +1 more source