Results 191 to 200 of about 648,932 (289)

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

Effect of gamma radiation on in vitro morphogenesis, anatomy and DNA polymorphism of Moringa concanensis Nimmo. [PDF]

Sci Rep
Gautam N, Faroda P, Shekhawat S, Gupta AK.   +3 more
europepmc   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, EarlyView.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

Exploring the shared genetic basis between autism spectrum disorder and gastrointestinal disorders: a bioinformatic study. [PDF]

Sci Rep
Malekpour M, Parhizkar M, Golabi F, Thompson R, Zakwani MA, Soleymanjahi S, Chohedri E.   +6 more
europepmc   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

Boosts in Polarization and Piezoelectric Responses of Lead‐Free Ferroelectrics through Strain‐Enhanced Glassy Coexistent Polars with High Dynamics

Advanced Science, EarlyView.
An effective strategy by constructing strain‐enhanced glassy coexistent polars near ferroelectric tricritical point to simultaneously improve polarization response and reduce energy loss is uncovered in (Ba0.84Ca0.16)0.985Bi0.01(Ti0.9Zr0.07Sn0.03)1‐x/100Hfx/100O3 (xHf) system and verified by phase‐field simulations with supporting high resolution ...
Liqiang He, Le Zhang, Yating Ran, Zibin Chen, Chuanxin Liang, Yanshuang Hao, Jianwei Li, Zhizhi Xu, Sen Yang, Michael A. Carpenter, Xiaobing Ren, Dong Wang   +11 more
wiley   +1 more source

Association Between <i>rs920778</i> Polymorphisms and Cancer Risk: An Updated Meta-Analysis. [PDF]

Genet Res (Camb)
Xu L, Deng J, Gong L, Chen Y, Hu G.
europepmc   +1 more source

A Study on the Cell Layer Patterns of a Citrus Periclinal Chimera Reveals β‐Cryptoxanthin Regulation in Citrus Fruits

Advanced Science, EarlyView.
Researchers have identified a citrus chimera with distinctive tissue origins and carotenoid profiles. It is discovered that fruit tissues develop from all three cell layers but in different proportions. A key transcription factor, MYB107, regulates β‐cryptoxanthin production by directly activating carotenoid biosynthesis genes, explaining why some ...
Chi Zhang, Kaijie Zhu, Zhehui Zhang, Huiyu Ji, Qun Wu, Lin Zhang, Fuzhi Ke, Gang Wang, Min Zhang   +8 more
wiley   +1 more source

Association between VEGF gene polymorphisms and breast cancer risk. [PDF]

Biochem Biophys Rep
Osman H, Hassan M, Alfaki M, Haj-Ali G.
europepmc   +1 more source

Metabolic syndrome and ADRB3 gene polymorphism in severely obese patients from South Italy [PDF]

, 2007
C Finelli, C Nardelli, F Contaldo, F Pasanisi, G Labruna, G Oriani, G Salvatori, L Sacchetti, P Buono, R Bracale   +9 more
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