Assessing the Impact of <i>VEGF</i> -2578C>A (rs699947) and -7C>T (rs2010963) Polymorphisms on Bladder Cancer Susceptibility: A Pilot Study. [PDF]
Siregar GP+3 more
europepmc +1 more source
Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang+13 more
wiley +1 more source
Investigating the genetic landscape of cancer in Jordan: a step toward personalized care. [PDF]
Al-Eitan LN+4 more
europepmc +1 more source
An effective strategy by constructing strain‐enhanced glassy coexistent polars near ferroelectric tricritical point to simultaneously improve polarization response and reduce energy loss is uncovered in (Ba0.84Ca0.16)0.985Bi0.01(Ti0.9Zr0.07Sn0.03)1‐x/100Hfx/100O3 (xHf) system and verified by phase‐field simulations with supporting high resolution ...
Liqiang He+11 more
wiley +1 more source
A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications. [PDF]
Shorbaji A+9 more
europepmc +1 more source
Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia+39 more
wiley +1 more source
Dopaminergic Modulation of Conscientiousness: <i>DRD2</i> rs1799732 and Personality Traits in Elite Mixed Martial Arts Athletes. [PDF]
Lachowicz M+7 more
europepmc +1 more source
Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li-Fraumeni syndrome and Cowden syndrome [PDF]
't Kint de Roodenbeke, Daphné+10 more
core
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong+9 more
wiley +1 more source
Exploring the interplay between host genetics and acute and long COVID: A narrative review. [PDF]
Beuren T+6 more
europepmc +1 more source