Results 261 to 270 of about 1,224,383 (281)

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Low-grade non-muscle-invasive urothelial carcinoma of the bladder in a 16-year-old boy with UGT1A1 polymorphism and Gilbert's syndrome: A case report. [PDF]

Urol Case Rep
N M, H B, Kp N, G MK, Ashok S, Jose Chirayath M, S Thomas R, Raj R, Mohan A, I Thomas A, Mary George T.   +10 more
europepmc   +1 more source

Direct Observation of Electric‐Field‐Driven Phase Transitions Associated with Energy Storage in Antiferroelectric Films

Advanced Science, EarlyView.
The electric‐field‐driven antiferroelectric‐to‐ferroelectric phase transition in epitaxial PbZrO3 films is directly visualized by in situ aberration‐corrected scanning transmission electron microscopy. A sequential transition pathway involving an orthorhombic ferrielectric phase and a monoclinic ferroelectric phase, ultimately stabilizing into a ...
Yan‐Peng Feng, Mei‐Xiong Zhu, Ru‐Jian Jiang, Yu‐Jia Wang, Yun‐Long Tang, Yin‐Lian Zhu, Xiu‐Liang Ma   +6 more
wiley   +1 more source

From nature-inspired electron acceptors to BioAIE materials with polarity- and polymorphism-dependence for anti-counterfeiting. [PDF]

Chem Sci
Wang D, Chen X, Lin Y, Wu L, Zhao Z, Xu X, Yang S, Zhang J, Wang WJ, Zhao Z, Wang S, Tang BZ, Cai XM.   +12 more
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Hidden faces of alpha-synuclein: Cryo-EM revelation of fibril polymorphs driven by disease, mutations, and PTMs. [PDF]

BBA Adv
Pirhaghi M, Mamashli F, Davaeil B, Mohammad-Zaheri M, Mousavi-Jarrahi Z, Tatzelt J, Saboury AA.   +6 more
europepmc   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Cellular Immunological Memory T Cells and <i>IL15RA</i> Gene Polymorphism in COVID-19 Vaccinated Individuals from Southern Brazil. [PDF]

Diagnostics (Basel)
Rodrigues GM, da Silva PP, Pinho MCF, Fischer TDS, de Paris F, Campos FS, Garcia ABM, Jataí LF, Ashton-Prolla P, Vianna FSL, Rosset C.   +10 more
europepmc   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Polymorphisms of the <i>MMP2</i> and <i>MMP9</i> genes in the development of aortic aneurysm in patients with bicuspid aortic valve. [PDF]

Turk Gogus Kalp Damar Cerrahisi Derg
Alur İ, Budak AB, Külahçıoğlu E, Kaya AD, Güneş T, Dodurga Y, Gökşin İ.   +6 more
europepmc   +1 more source