Results 261 to 270 of about 1,187,841 (331)

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Exploring the Prognostic Significance of IL10 Variants and Their Mechanistic Regulation in Diabetic Nephropathy. [PDF]

J Cell Mol Med
Shukla N, Kumari S, Verma P, Srivastava A, Singh N, Rao GM, Prasad N, Gupta S, Srivastava A, Ansari MS, Janakiraman S, Baden M, Wolkenhauer O, Gupta SK, Gautam NK.   +14 more
europepmc   +1 more source

A paraoxonase gene polymorphism, PON 1 (55), as an independent risk factor for increased carotid intima-media tickness in middle-aged women. [PDF]

, 2003
DE MICHELE M, FORTUNATO G, IANNUZZI A, MAZZACCARA, CRISTINA, PANICO, SALVATORE, RUBBA, PAOLO OSVALDO FEDERICO, SACCHETTI L., SALVATORE F, TINTO, NADIA, TRONO D, VITALE DF   +10 more
core  

Genetic Deconvolution of Embryonic and Maternal Cell‐Free DNA in Spent Culture Medium of Human Preimplantation Embryo Through Deep Learning

Advanced Science, EarlyView.
DECENT is a deep learning method that enhances noninvasive preimplantation genetic testing by accurately reconstructing embryonic copy number variations (CNVs) from cell‐free DNA in spent embryo culture media. By mitigating maternal contamination, DECENT improves diagnostic accuracy, even with high contamination levels, offering a reliable, noninvasive
Zhenyi Zhang, Jie Qiao, Yidong Chen, Peijie Zhou   +3 more
wiley   +1 more source

MITOCHONDRIAL POLYMORPHISM IN MAIZE. II. FURTHER EVIDENCE OF CORRELATION OF MITOCHONDRIAL COMPLEMENTATION AND HETEROSIS

, 1967
Igor V. Sarkissian, Hari K. Srivastava
openalex   +2 more sources

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, EarlyView.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

FGFR4 p.Gly388Arg polymorphism in PBMCs of LAM patients: findings of a pilot study. [PDF]

Front Med (Lausanne)
Koc-Gunel S, Ryan AL, Winter M, Wagner TOF.   +3 more
europepmc   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Association between the PSCA rs2976392 polymorphism and susceptibility to gastric cancer: a meta-analysis. [PDF]

Front Genet
Lin XH, Chen DJ, Wang LJ, Wan XP.
europepmc   +1 more source