Results 51 to 60 of about 674,439 (312)

Biological and genetic evaluation of IL-23/IL-17 pathway in ankylosing spondylitis patients

Central European Journal of Immunology, 2020
Ankylosing spondylitis is the most common form of the chronic inflammatory disease group known as spondyloarthritides. Recent discoveries of the CD4+ Th17 cells and IL-23/IL-17 axis have changed the paradigms in many autoimmune diseases.
Hulya Deveci, Ayla Turk, Zeliha Ozmen, Ayse Demir, Safiye Coskun   +4 more
doaj   +1 more source

The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. [PDF]

, 2011
AIMS: Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait where genetic variations and environment interact to determine disease progression.
Patch, Julia, J. Patch, Ann K. Daly, J. B. S. Leathart, Quentin M. Anstee, Julian B.S. Leathart, Julia Patch, Christopher P. Day, Nobili, Valerio, Valerio Nobili, Anna Fracanzani, Silvia Fargion, Q. M. Anstee, Leathart, Julian B S, Day, Christopher P, Daly, Ann K, L. Valenti, Ahmad Al-Serri, S. Fargion, Paola Dongiovanni, Al Serri, Ahmad, Anstee, Quentin M, Fracanzani, Anna, Dongiovanni, Paola, C. P. Day, A. Fracanzani, A. Al Serri, V. Nobili, A. K. Daly, Valenti, Luca, P. Dongiovanni, Luca Valenti, Fargion, Silvia   +32 more
core   +1 more source

The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype [PDF]

, 2022
OBJECTIVE: A functional polymorphism on the 16th exon of the alpha-actinin-3 gene has an effect on the protein structure and cellular signaling and therefore on muscle contraction.
Özdemir, Fulya, Ulucan, Korkut, Korkut Ulucan, Fulya Özdemir, Funda Eken, Başak, Hussain Nihad Izaddin Alalim, Başak Funda Eken, Nihad Izaddin Alalim, Hussain   +7 more
core   +1 more source

Association of leptin receptor gene polymorphisms and meta-inflammation markers with metabolically unhealthy obesity in children

Zaporožskij Medicinskij Žurnal, 2021
The aim: to study the contribution of single-nucleotide polymorphisms (SNP) of the leptin receptor (LEPR) gene and meta-inflammation markers to the formation of metabolically unhealthy obesity (MUO) in children. Materials and methods.
А. Е. Abaturov, A. O. Nikulina
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic polymorphism of blood proteins in a population of shetland ponies [PDF]

, 1976
Genetic variation of proteins (protein polymorphism) is widespread among many animal species. The biological significance of protein polymorphism has been the subject of many studies.
Buis, R.C.
core  

Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction [PDF]

, 2008
Background: This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality ...
Sakellariou Dimitris C, Tzeis Stylianos E, Richter, Dimitris J., Gialafos Elias J, Gialafos, Elias J., Elias J Gialafos, Andrikopoulos George K, Toutouzas Pavlos K, Richter Dimitris J, George K Andrikopoulos, Edward W Hillhouse, Grammatopoulos, Dimitris, Stefanos G Foussas, Stylianos E Tzeis, Grammatopoulos Dimitris K, Sakellariou, Dimitris C., Michalis N Zairis, Zervou Sevasti I, Manolis Antonis S, Manolis, Antonis S., Toutouzas, Pavlos K., Dimitris K Grammatopoulos, Foussas Stefanos G, Tzeis, Stylianos E., Zairis Michalis N, Christodoulos I Stefanadis, Stefanadis, Christodoulos I., Foussas, Stefanos G., Dimitris C Sakellariou, Sevasti I Zervou, Antonis S Manolis, Zervou, Sevasti I., null null, Andrikopoulos, George K., Zairis, Michalis N., Hillhouse Edward W, Dimitris J Richter, Stefanadis Christodoulos I, Hillhouse, Edward W., Pavlos K Toutouzas   +39 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease. [PDF]

, 2010
Recent evidence suggests a crucial role of the endocannabinoid system, including the cannabinoid 1 receptor (CNR1), in intestinal inflammation. We therefore investigated the influence of the CNR1 1359 G/A (p.Thr453Thr; rs1049353) single nucleotide ...
Brand, Stephan, Burkhard Göke, Göke, Burkhard, Storr, Martin, Göke Burkhard, Ochsenkühn, Thomas, Stephan Brand, Brand Stephan, Thomas Ochsenkühn, Storr Martin, Pfennig, Simone, Dominik Emmerdinger, Peter Lohse, Martin Storr, Emmerdinger Dominik, Diegelmann, Julia, Lohse, Peter, Simone Pfennig, Diegelmann Julia, Emmerdinger, Dominik, Julia Diegelmann, Ochsenkühn Thomas, Lohse Peter, Pfennig Simone   +23 more
core   +1 more source

Different inflammatory, fibrotic, and immunologic signatures between pre-fibrotic and overt primary myelofibrosis

Haematologica
Primary myelofibrosis (PMF) is a myeloid proliferative neoplasm (MPN) characterized by bone marrow (BM) fibrosis. Pre-fibrotic PMF (pre-PMF) progresses to overt PMF.
Seung-Hyun Jung, Sung-Eun Lee, Sujin Yun, Da-Eun Min, Youngjin Shin, Yeun-Jun Chung, Sug Hyung Lee   +6 more
doaj   +1 more source