Results 41 to 50 of about 692,170 (312)

Row and Bounded Polymorphism via Disjoint Polymorphism [PDF]

, 2020
Polymorphism and subtyping are important features in mainstream OO languages. The most common way to integrate the two is via _{< :} style bounded quantification. A closely related mechanism is row polymorphism, which provides an alternative to subtyping,
Oliveira, Bruno C. d. S., Schrijvers, Tom, Xie, N, Bi, Xuan, Dos Santos Oliveira, BC, Schrijvers, T, Oliveira, Bruno C.DS., Xie, Ningning, Bi, X   +8 more
core   +1 more source

Association of leptin receptor gene polymorphisms and meta-inflammation markers with metabolically unhealthy obesity in children

Zaporožskij Medicinskij Žurnal, 2021
The aim: to study the contribution of single-nucleotide polymorphisms (SNP) of the leptin receptor (LEPR) gene and meta-inflammation markers to the formation of metabolically unhealthy obesity (MUO) in children. Materials and methods.
А. Е. Abaturov, A. O. Nikulina
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Polymorphism-specific rank-based tests (p values) of genotype differences in virus load.

, 2017
Polymorphism-specific rank-based tests (p values) of genotype differences in virus load.
Florian Wrensch (566210), Stefan Pöhlmann (142445), Michael Winkler (119116), Michael Krawczak (77525), Ulrike Sauermann (201269), Sabine Gärtner (566211)   +5 more
core   +1 more source

Killing them softly:managing pathogen polymorphism and virulence in spatially variable environments [PDF]

, 2013
Understanding why pathogen populations are genetically variable is vital because genetic variation fuels evolution, which often hampers disease control efforts.
Vale, Pedro F; id_orcid
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers [PDF]

, 2006
BackgroundThe MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce accelerated tumour formation in ...
Johnson, Peter W., White Helen E, Jeremy P Blaydes, Diana M Eccles, White, Helen E., Ellen R Copson, Johnson Peter W, Eccles Diana M, Eccles, Diana M., Helen E White, Robinson, David O., David O Robinson, Peter W Johnson, Blaydes, Jeremy P., Copson, Ellen R., Robinson David O, Copson Ellen R, Blaydes Jeremy P   +17 more
core   +2 more sources

Different inflammatory, fibrotic, and immunologic signatures between pre-fibrotic and overt primary myelofibrosis

Haematologica
Primary myelofibrosis (PMF) is a myeloid proliferative neoplasm (MPN) characterized by bone marrow (BM) fibrosis. Pre-fibrotic PMF (pre-PMF) progresses to overt PMF.
Seung-Hyun Jung, Sung-Eun Lee, Sujin Yun, Da-Eun Min, Youngjin Shin, Yeun-Jun Chung, Sug Hyung Lee   +6 more
doaj   +1 more source

Frequency of Gc-globin promoter –158 (C>T) XmnI polymorphism in patients with homozygous/compound heterozygous beta thalassaemia

Hematology/Oncology and Stem Cell Therapy, 2015
BACKGROUND: Response to hydroxyurea therapy in homozygous or compound heterozygous beta thalassaemia (BT) has been reported as more favourable in the presence of XmnI polymorphism.
Nadir Ali, Muhammad Ayyub, Saleem Ahmed Khan, Suhaib Ahmed, Kazim Abbas, Hamid Saeed Malik, Sunila Tashfeen   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source