Comparison of the Genetic Alterations between Primary Colorectal Cancers and Their Corresponding Patient-Derived Xenograft Tissues [PDF]
Genomics & Informatics, 2018 Patient-derived xenograft (PDX) models are useful tools for tumor biology research and testing the efficacy of candidate anticancer drugs targeting the druggable mutations identified in tumor tissue.
Sang Mi Yu +2 more
doaj +1 more source
Frontiers in Genetics, 2022 Background: To decipher mutational signatures and their associations with biological implications in cutaneous melanomas (CMs), including those with a low ultraviolet (UV) signature.Materials and Methods: We applied non-negative matrix factorization (NMF)
Yoon-Seob Kim +7 more
doaj +1 more source
A Variant in Is Associated with the Risk of Ankylosing Spondylitis in Koreans [PDF]
Genomics & Informatics, 2017 Ankylosing spondylitis (AS) is a chronic autoinflammatory disease that affects the spine and sacroiliac joints. Regarding its etiology, although HLA-B27 is known to be the strongest genetic factor of AS, much evidence suggests the potential contribution ...
Sung-Min Cho +2 more
doaj +1 more source
Validation of Customized Cancer Panel for Detecting Somatic Mutations and Copy Number Alterations [PDF]
Genomics & Informatics, 2017 Accurate detection of genomic alterations, especially druggable hotspot mutations in tumors, has become an essential part of precision medicine.
Su-Hye Choi +2 more
doaj +1 more source
PolyMorph: A P300 Polymorphic Speller [PDF]
, 2013 P300 is an electric signal emitted by brain about 300 milliseconds after a rare, but relevant-for-the-user event. Even if it is hard to identify and it provides a low-rate communication channel, it can be used in cases in which other evoked potentials fail.
CASAGRANDE, ALBERTO +4 more
openaire +4 more sources
Angiotensin-converting enzyme insertion/deletion polymorphism does not influence the restenosis rate after coronary stent implantation [PDF]
, 2002 Background. Experimental studies have shown an activation of the angiotensin-converting enzyme (ACE) system as a response to endothelial injury. Recent publications have elucidated the hypothesis that the ACE gene polymorphism may influence the level of ...
Hausmann, Dirk +10 more
core +1 more source
Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene. [PDF]
, 2006 Apolipoprotein AV (ApoAV) gene variant, -1131T>C, is associated with increased triglyceride concentrations in all ethnic groups studied. An MseI based RFLP analysis is the most commonly used method for genotyping this SNP.
Andrew T Hattersley +20 more
core +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2023 Genetic variation remains a topic of great interest due to its potential as a risk factor for various diseases. Interactions between genes contribute to diverse phenotypes in response to factors such as infection.
Darnifayanti Darnifayanti +3 more
doaj +1 more source
Impact of mating systems on patterns of sequence polymorphism in flowering plants [PDF]
, 2006 A fundamental challenge in population genetics and molecular evolution is to understand the forces shaping the patterns of genetic diversity within and among species.
Deborah Charlesworth +5 more
core +1 more source
Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]
, 2003 Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A. +8 more
core +1 more source