Results 81 to 90 of about 674,439 (312)

Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations [PDF]

, 2008
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties.
G. Veres, Földi, I., I. R. Korponay-Szabo, M. Udvardy, Veres, Gábor, Udvardy, M., Korponay-Szabó, Ilma Rita, Tumpek, J., L. Toth, Mate, I., Toth, L., Gyetvai, A., Szathmari, E., Altorjay, István, Nemes, E., A. Gyetvai, E. Szathmari, Papp, Mária, Dinya, T., Varvolgyi, C., J. Tumpek, T. Dinya, Z. Barta, E. Nemes, I. Mate, J. Harsfalvi, Hársfalvi, Jolán, C. Varvolgyi, I. Foldi, Lakatos, Péter László, Kapitany, A., P. L. Lakatos, M. Papp, A. Kapitany, I. Altorjay, Barta, Zsolt   +35 more
core   +1 more source

Evaluation of usefulness of single-strand conformation polymorphism method for rapid detection of rifampicin-resistant mycobacterium tuberculosis [PDF]

Vojnosanitetski Pregled, 2004
The aim was to evaluate the Single-Strand Conformation Polymorphism method as a potential tool for rapid detection of rifampicin-resistant strains by the use of 39 rifampicin-resistant Mycobacterium tuberculosis strains isolated in Serbia.
Tešić Jelena, Lepšanović Zorica, Mirović Veljko   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population [PDF]

, 2009
Background: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility.
Britten, Abigail C, Barnett Anthony H, Barnett, Anthony, Britten, Abigail C., Bellary, S, Barnett, Anthony H., Anthony H Barnett, Kumar Sudhesh, Rees, Simon D, Britten, Abigail, Sudhesh Kumar, O'Hare, J Paul, Kelly, M Ann, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Kelly, Marilyn, Britten Abigail C, Kelly M Ann, Bellary, Srikanth, Rees Simon D, Srikanth Bellary, Abigail C Britten, J Paul O'Hare, Bellary Srikanth, O'Hare, JP, Kumar, Sudhesh, Barnett, Anthony H, Simon D Rees, Barnett, A. H., O'Hare J Paul, Kumar, S, O'Hare, J. Paul, M Ann Kelly   +33 more
core   +3 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

GH responsiveness in a large multinational cohort of SGA children with short stature (NESTEGG) is related to the exon 3 GHR polymorphism [PDF]

, 2007
Objective: The polymorphic deletion of exon 3 of the GH receptor (d3-GHR) has recently been linked to the magnitude of growth response to recombinant human GH (rhGH) therapy in short children with or without GH deficiency.
Ranke, MB, Ester, W.A. (Wietske), Johnston, L.B., Tauber, M, Fryklund, L, Fauvel, J, Fauvel, J., Ranke, M.B., Johnston, LB, Hokken-Koelega, AC, Ester, WA (Wietske), Auriol, F., Nugent, T., Savage, M.O., Molinas, C. (Catherine), Molinas, C, Hokken - Koelega, Anita, Auriol, F, Ester, W, NESTEGG group, Savage, MO, Caliebe, J, Clark, AJ, Fryklund, L., Caliebe, J. (Janina), Nugent, T, Tauber, M., Clark, A.J.L., Hokken-Koelega, A.C.S. (Anita), Clark, AJL   +29 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Genomic investigation of NDM-1 producing Enterobacterales transmission in a South Korean hospital

Journal of Global Antimicrobial Resistance
Objective: Prolonged detection of multispecies New Delhi metallo-β-lactamase (NDM)-1-producing Enterobacterales was observed in front of a South Korean hospital.
Jeong-Ih Shin, Sun Hee Park, Chulmin Park, Seung-Hyun Jung, Dong-Gun Lee   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Prevalence and Genomic Characterization of Listeria monocytogenes in Retail Beef and Farm Samples in Korea

Journal of Food Protection
Listeria monocytogenes (Lm) is a major foodborne pathogen that can persist in food-processing environments and is responsible for listeriosis outbreaks.
Jiyon Chu, Jeong-Ih Shin, Mi Ru Lee, Yeun-Jun Chung, Kun Taek Park, Seung-Hyun Jung   +5 more
doaj   +1 more source