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Current Medicinal Chemistry, 2013
Polymyxins are polypeptide antibiotics, with a primary effect of membrane damaging due to their selective binding to the lipopolysaccharide of Gram-negative bacteria. Their nephro- and neurotoxic side effects limited their use, however, in the last decade the emergence of multidrug-resistant Gram-negative bacteria led to the reintroduction of ...
B, Kadar, B, Kocsis, K, Nagy, D, Szabo
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Polymyxins are polypeptide antibiotics, with a primary effect of membrane damaging due to their selective binding to the lipopolysaccharide of Gram-negative bacteria. Their nephro- and neurotoxic side effects limited their use, however, in the last decade the emergence of multidrug-resistant Gram-negative bacteria led to the reintroduction of ...
B, Kadar, B, Kocsis, K, Nagy, D, Szabo
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Archives of Pediatrics & Adolescent Medicine, 1984
Sir .—It was with a mixture of interest and personal chagrin that I read the article by Larter et al 1 on polymyxin B sulfate and pertussis vaccine—interest because I have been a sometime advocate of this particular application of the endotoxin-inactivating activity of polymyxin B, but chagrin that, in this narrow field, reference to my own publication
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Sir .—It was with a mixture of interest and personal chagrin that I read the article by Larter et al 1 on polymyxin B sulfate and pertussis vaccine—interest because I have been a sometime advocate of this particular application of the endotoxin-inactivating activity of polymyxin B, but chagrin that, in this narrow field, reference to my own publication
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Archives of Dermatology, 1963
To the Editor : In the June, 1961, issue of theArchives of Dermatology, G. Asboe-Hansen, M.D., Copenhagen, Denmark, reported the therapeutical essay of polymyxin B (Pfizer) in a case of generalized mastocytosis. We tried this treatment, utilizing disyncran as a cover against histamine liberation, in a case of urticaria pigmentosa which had resisted ...
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To the Editor : In the June, 1961, issue of theArchives of Dermatology, G. Asboe-Hansen, M.D., Copenhagen, Denmark, reported the therapeutical essay of polymyxin B (Pfizer) in a case of generalized mastocytosis. We tried this treatment, utilizing disyncran as a cover against histamine liberation, in a case of urticaria pigmentosa which had resisted ...
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Nomenclature of Polymyxin Antibiotics
Nature, 1949POLYMYXIN is a term introduced by Stansly, Shepherd and White1 for an antibiotic substance elaborated by Bacillus polymyxa.
P G, STANSLY, G, BROWNLEE
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2019
The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development.
Zhifeng, Li, Tony, Velkov
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The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development.
Zhifeng, Li, Tony, Velkov
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Mechanisms of Polymyxin Resistance
2019Polymyxin antibiotics are increasingly being used as last-line therapeutic options against a number of multidrug resistant bacteria. These antibiotics show strong bactericidal activity against a range of Gram-negative bacteria, but with the increased use of these antibiotics resistant strains are emerging at an alarming rate.
Jennifer H, Moffatt +2 more
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Annals of the New York Academy of Sciences, 1949
J R, CATCH, T S G, JONES, S, WILKINSON
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J R, CATCH, T S G, JONES, S, WILKINSON
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2000
Abstract Polymyxin B and polymyxin E (colistin) are microorganism derived antibiotics effective against Gram-negative bacteria. Although parenteral administration is accompanied by nephrotoxicity and neurotoxicity, intravenous colistin is effective in treating acute respiratory exacerbations associated with Pseudomonas aeruginosa in ...
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Abstract Polymyxin B and polymyxin E (colistin) are microorganism derived antibiotics effective against Gram-negative bacteria. Although parenteral administration is accompanied by nephrotoxicity and neurotoxicity, intravenous colistin is effective in treating acute respiratory exacerbations associated with Pseudomonas aeruginosa in ...
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