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Polymyxins: recent advances and challenges [PDF]
Frontiers in PharmacologyAntibiotic resistance is a pressing global health challenge, and polymyxins have emerged as the last line of defense against multidrug-resistant Gram-negative (MDR-GRN) bacterial infections.
Shurong Zhang
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Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics [PDF]
Frontiers in Microbiology, 2019 The discovery of polymyxins, highly basic lipodecapeptides, was published independently by three laboratories in 1947. Their clinical use, however, was abandoned in the sixties because of nephrotoxicity and because better-tolerated drugs belonging to ...
Martti Vaara
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Microbiology Spectrum, 2023 High-alcohol-producing K. pneumoniae (HiAlc Kpn) causes nonalcoholic fatty liver disease (NAFLD) by producing excess endogenous alcohol in the gut of patients with NAFLD, using glucose as the main carbon source.
Ziying Xu, Tongtong Fu
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Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane [PDF]
Communications BiologyPolymyxins are often administered as last resort antibiotics for Gram-negative bacterial infections. However, given unwanted side-effects, efficacy and recent reports of resistance against polymyxins, there is an urgency to develop alternatives.
Dheeraj Prakaash, Syma Khalid
doaj +3 more sources
PLoS ONE, 2014 BackgroundMulti-drug resistance among Acinetobacter baumannii increases the need for polymyxins. We conducted a meta-analysis aimed to assess the efficacy and safety of polymyxins for the treatment of Acinetobacter baumannii infection.MethodsWe searched ...
Zhuoyun Tang, Qianqian Liu
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Polypeptide Self-Assembled Nanoparticles as Delivery Systems for Polymyxins B and E [PDF]
Pharmaceutics, 2020 Polymyxins are peptide antibiotics that are highly efficient against many multidrug resistant pathogens. However, the poor stability of polymyxins in the bloodstream requires the administration of high drug doses that, in turn, can lead to polymyxin ...
Evgenia Korzhikova-Vlakh +2 more
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Polymyxins and Bacterial Membranes: A Review of Antibacterial Activity and Mechanisms of Resistance [PDF]
Membranes, 2020 Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to their potential clinical toxicity, especially nephrotoxicity.
Carole Ayoub Moubareck
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Development of polymyxin- and aminoglycoside-based outer membrane permeabilizers: a review [PDF]
Frontiers in MicrobiologyThe prevalence of antimicrobial resistance (AMR) necessitates the development of alternative therapeutic options, particularly against critical priority Gram-negative pathogens.
Danzel Marie Ramirez +2 more
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Colistin Resistance: From Laboratory Research to Modern Clinical Management [PDF]
AntibioticsBackground/Objectives: Colistin, a polymyxin antibiotic introduced in the mid-20th century, has regained clinical importance as a last-resort agent for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria.
Hakan Erdem, Gulden Yilmaz-Tehli
doaj +2 more sources
Next-Generation Polymyxin Class of Antibiotics: A Ray of Hope Illuminating a Dark Road
Antibiotics, 2022 Although new-generation antimicrobials, in particular β-lactam/β-lactamase inhibitors, have largely replaced polymyxins in carbapenem-resistant Gram-negative bacterial infections, polymyxins are still needed for carbapanem-resistant Acinetobacter ...
Abdullah Tarık Aslan +2 more
doaj +1 more source