Results 1 to 10 of about 43,976 (255)
Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens [PDF]
Frontiers in Microbiology, 2018 Due to limited new antibiotics, polymyxins are increasingly used to treat multidrug-resistant (MDR) Gram-negative bacteria, in particular carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.
Yohei Doi +2 more
exaly +5 more sources
Frontiers in Pharmacology, 2023 Objective: To investigate the clinical efficacy and toxicity of nebulized polymyxin monotherapy and combined intravenous and nebulized polymyxin for the treatment of VAP caused by CR-GNB.
Qiyu Wang
exaly +3 more sources
Microbiology Spectrum, 2022 Carbapenem-resistant Gram-negative bacteria (CRGNB)-related health care-associated ventriculitis and meningitis (HCAVM) is dangerous. We aimed to report the antimicrobial resistance of the pathogens, treatment, and outcome.
Yi Ye +3 more
doaj +1 more source
Frontiers in Microbiology, 2023 IntroductionMatrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) is a powerful analytical technique that has been applied to a wide variety of applications ranging from proteomics to clinical diagnostics.
Wenhao Tang +3 more
doaj +1 more source
Structures of Polymyxin B2 and Polymyxin E1 [PDF]
Nature, 1964 IN a previous communication1, from the analysis of a partial acid hydrolysate, the structure of polymyxin E1 was shown to be limited to two alternatives, the so-called 7 α and 8γ formulae. By applying the enzyme method of hydrolysis as devised by Suzuki et al. in their determinations of the structures of polymyxin B1 (ref. 2) and colistin A (ref.
S, WILKINSON, L A, LOWE
openaire +3 more sources
Evaluation of Polymyxin NP Test as a Rapid Method for Detection of Polymyxins Resistance in Enterobacteriaceae [PDF]
Afro-Egyptian Journal of Infectious and Endemic Diseases, 2023 Background and study aim: Polymyxins are considered the last remedy for multidrug-resistant Enterobacteriaceae. However, due to their overuse, Polymyxin resistance rose and posed the urge to find new methods to aid their rapid diagnosis.
Sherin ElMasry +2 more
doaj +1 more source
Clinical Microbiology Reviews, 2008 SUMMARY The global emergence of multidrug-resistant gram-negative bacilli has spurred a renewed interest in polymyxins. Once discarded due to concerns regarding nephrotoxicity and neurotoxicity, polymyxins now hold an important role in the antibiotic armamentarium.
David, Landman +3 more
openaire +2 more sources
Antibiotics, 2021 Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of mcr and blaNDM in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments ...
Dongyue Lv +11 more
doaj +1 more source
Structures of the Polymyxins A and the Question of Identity with the Polymyxins M [PDF]
Nature, 1966 THE elucidation of the structures of the polymyxins and the related antibiotic circulin A has so far revealed a remarkable consistency. Polymyxins B1 and B2 (refs. 1 and 2), polymyxins E1 and E2 (identical with colistins A and B, respectively)3,4, and circulin A (ref.
S, Wilkinson, L A, Lowe
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Frontiers in Microbiology, 2020 Currently, Gram-negative bacteria have developed multidrug and broad-spectrum drug resistance, and the numbers of species and strains carrying mcr or blaNDM genes are increasing.
Rong Fan +9 more
doaj +1 more source