Results 21 to 30 of about 7,789 (207)

Retrospective Screening and Analysis of mcr-1 and blaNDM in Gram-Negative Bacteria in China, 2010–2019

Frontiers in Microbiology, 2020
Currently, Gram-negative bacteria have developed multidrug and broad-spectrum drug resistance, and the numbers of species and strains carrying mcr or blaNDM genes are increasing.
Rong Fan, Chuchu Li, Chuchu Li, Ran Duan, Shuai Qin, Junrong Liang, Meng Xiao, Dongyue Lv, Huaiqi Jing, Xin Wang   +9 more
doaj   +1 more source

Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae

mSphere, 2023
Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters for the delivery of cargo such as virulence and antibiotic resistance factors.
Maytham Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha J. Thombare, James Ziogas, Aayush Purohit, Gauri G. Rao, Jian Li, Tony Velkov   +9 more
doaj   +1 more source

Comparative Neurotoxicity of Polymyxin B and Colistin in Patients With Cancer

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.
ABSTRACT Background The polymyxins, polymyxin B and colistin, are last‐line options for the treatment of infections caused by drug‐resistant gram‐negative organisms. The comparative neurotoxicity of these agents using contemporary dosing is poorly understood.
Samuel L Aitken, Emily Aboujaoude, Jovan Borjan, Frank P. Tverdek   +3 more
openalex   +2 more sources

Progress in the study of polymyxin resistance and its mechanism

Shanghai yufang yixue, 2022
Drug-resistant bacteria have become a serious threat to human health. Polymyxin has shown strong bactericidal activity to some Gram-negative and Gram-positive bacteria that are resistant to antibiotics， and has become a last-resort treatment option ...
CAI Jia’an, JIANG Lufang, JIANG Qingwu
doaj   +1 more source

Low-dose intravenous plus inhaled versus intravenous polymyxin B for the treatment of extensive drug-resistant Gram-negative ventilator-associated pneumonia in the critical illnesses: a multi-center matched case–control study

Annals of Intensive Care, 2022
Background The mortality of extensively drug-resistant Gram-negative (XDR GN) bacilli-induced ventilator-associated pneumonia (VAP) is extremely high. The purpose of this study was to compare the efficacy and safety of inhaled (IH) plus intravenous (IV ...
Jiao Liu, Min Shao, Qianghong Xu, Fen Liu, Xiaojun Pan, Jianfeng Wu, Lihong Xiong, Yueming Wu, Mi Tian, Jianying Yao, Sisi Huang, Lidi Zhang, Yizhu Chen, Sheng Zhang, Zhenliang Wen, Hangxiang Du, TaoWang, Yongan Liu, Wenzhe Li, Yan Xu, Jean-louis Teboul, Dechang Chen   +21 more
doaj   +1 more source

Comparison of Gene Expression Profiles of Uropathogenic Escherichia Coli CFT073 after Prolonged Exposure to Subinhibitory Concentrations of Different Biocides

Antibiotics, 2019
Biocides are chemical compounds widely used for sterilization and disinfection. The aim of this study was to examine whether exposure to subinhibitory biocide concentrations influenced transcriptional expression of genes that could improve a pathogen ...
Małgorzata Ligowska-Marzęta, Viktoria Hancock, Hanne Ingmer, Frank M. Aarestrup   +3 more
doaj   +1 more source

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

Frontiers in Pharmacology, 2019
Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies.
Mei-Ling Han, Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Darren J. Creek, Christopher K. Barlow, Heidi H. Yu, Zhihui Zhou, Jing Zhang, Jian Li, Jian Li   +12 more
doaj   +1 more source

Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae

Microbiology Spectrum, 2023
Polymyxins are last-line antibiotics employed against multidrug-resistant (MDR) Klebsiella pneumoniae. Worryingly, polymyxin resistance is rapidly on the rise globally.
Jing Lu, Meiling Han, Heidi H. Yu, Phillip J. Bergen, Yiyun Liu, Jinxin Zhao, Hasini Wickremasinghe, Xukai Jiang, Yang Hu, Haiyan Du, Yan Zhu, Tony Velkov   +11 more
doaj   +1 more source

Polymyxin B Nephrotoxicity: From Organ to Cell Damage. [PDF]

PLoS ONE, 2016
Polymyxins have a long history of dose-limiting toxicity, but the underlying mechanism of polymyxin B-induced nephrotoxicity is unclear. This study investigated the link between the nephrotoxic effects of polymyxin B on renal metabolic functions and ...
Maria de Fátima Fernandes Vattimo, Mirian Watanabe, Cassiane Dezoti da Fonseca, Luciana Barros de Moura Neiva, Edson Andrade Pessoa, Fernanda Teixeira Borges   +5 more
doaj   +1 more source

Efficacy and safety of polymyxin B in carbapenem-resistant gram-negative organisms infections

BMC Infectious Diseases, 2021
Objective To investigate how to use polymyxin B rationally in order to produce the best efficacy and safety in patients with carbapenem-resistant gram-negative organisms (CRO) infection. Methods The clinical characteristics and microbiological results of
G. L. Xia, R. L. Jiang
doaj   +1 more source