Results 21 to 30 of about 43,976 (255)

Low-dose intravenous plus inhaled versus intravenous polymyxin B for the treatment of extensive drug-resistant Gram-negative ventilator-associated pneumonia in the critical illnesses: a multi-center matched case–control study

Annals of Intensive Care, 2022
Background The mortality of extensively drug-resistant Gram-negative (XDR GN) bacilli-induced ventilator-associated pneumonia (VAP) is extremely high. The purpose of this study was to compare the efficacy and safety of inhaled (IH) plus intravenous (IV ...
Jiao Liu, Min Shao, Qianghong Xu, Fen Liu, Xiaojun Pan, Jianfeng Wu, Lihong Xiong, Yueming Wu, Mi Tian, Jianying Yao, Sisi Huang, Lidi Zhang, Yizhu Chen, Sheng Zhang, Zhenliang Wen, Hangxiang Du, TaoWang, Yongan Liu, Wenzhe Li, Yan Xu, Jean-louis Teboul, Dechang Chen   +21 more
doaj   +1 more source

Comparison of Gene Expression Profiles of Uropathogenic Escherichia Coli CFT073 after Prolonged Exposure to Subinhibitory Concentrations of Different Biocides

Antibiotics, 2019
Biocides are chemical compounds widely used for sterilization and disinfection. The aim of this study was to examine whether exposure to subinhibitory biocide concentrations influenced transcriptional expression of genes that could improve a pathogen ...
Małgorzata Ligowska-Marzęta, Viktoria Hancock, Hanne Ingmer, Frank M. Aarestrup   +3 more
doaj   +1 more source

Selective Reductive Cleavage of the Threonine 2 Peptide Bond of Penta-N-Boc-Polymyxin B with Sodium Borohydride

, 2022
Sodium borohydride surprisingly cleaves the Threonine2 (Thr2) peptide bond in N-protected Polymyxin B. Occurring at 20 ºC, the mild reductive cleavage is novel; and it facilitates the synthesis of PMB-derived antibiotics.
Adriano, Afonso, Jay, Weinstein
core   +1 more source

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii

Frontiers in Pharmacology, 2019
Background: Polymyxins are a last-line class of antibiotics against multidrug-resistant Acinetobacter baumannii. However, polymyxin resistance can emerge with monotherapy, highlighting the need for synergistic combination therapies.
Mei-Ling Han, Mei-Ling Han, Xiaofen Liu, Tony Velkov, Yu-Wei Lin, Yan Zhu, Darren J. Creek, Christopher K. Barlow, Heidi H. Yu, Zhihui Zhou, Jing Zhang, Jian Li, Jian Li   +12 more
doaj   +1 more source

RapidResa Polymyxin Acinetobacter NP® Test for Rapid Detection of Polymyxin Resistance in Acinetobacter baumannii

, 2021
A homemade and culture-based test, relying on the visual detection of the reduction of the resazurin reagent (a cell viability indicator), has been developed for the rapid detection of polymyxin resistance in Acinetobacter baumannii.
Maxime Bouvier, Stefano Pomponio, Fernando D’Emidio, Laurent Poirel, Sadek, M., Poirel, L., Nordmann, P., Mustafa Sadek, Pomponio, S., D'Emidio, F., Patrice Nordmann, Bouvier, M.   +11 more
core   +1 more source

Towards Clinical Applications of Anti-endotoxin Antibodies; A Re-appraisal of the Disconnect

Toxins, 2013
Endotoxin is a potent mediator of a broad range of patho-physiological effects in humans. It is present in all Gram negative (GN) bacteria. It would be expected that anti-endotoxin therapies, whether antibody based or not, would have an important ...
James C. Hurley
doaj   +1 more source

Efficacy and safety of polymyxin B in carbapenem-resistant gram-negative organisms infections

BMC Infectious Diseases, 2021
Objective To investigate how to use polymyxin B rationally in order to produce the best efficacy and safety in patients with carbapenem-resistant gram-negative organisms (CRO) infection. Methods The clinical characteristics and microbiological results of
G. L. Xia, R. L. Jiang
doaj   +1 more source

Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae

Microbiology Spectrum, 2023
Polymyxins are last-line antibiotics employed against multidrug-resistant (MDR) Klebsiella pneumoniae. Worryingly, polymyxin resistance is rapidly on the rise globally.
Jing Lu, Meiling Han, Heidi H. Yu, Phillip J. Bergen, Yiyun Liu, Jinxin Zhao, Hasini Wickremasinghe, Xukai Jiang, Yang Hu, Haiyan Du, Yan Zhu, Tony Velkov   +11 more
doaj   +1 more source

Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria [PDF]

, 2022
Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria.
Lisa Bohlmann, Brouwer, Stephan, Brouwer, S., Harbison-Price, Nichaela, Andrew J. Hayes, David L. Paterson, Davies, M.R., Keller, Nadia, El-Deeb, I.M., Mark J. Walker, Keller, B., El-Deeb, Ibrahim M, Alastair G. McEwan, Andrew G. Turner, Ibrahim M. El-Deeb, von Itzstein, Mark, Hayes, A.J., Turner, A.G., Thomas R. Jones, Cork, A.J., Mark R. Davies, Christopher A. McDevitt, Ong, C.-L.Y., Amanda J. Cork, Li, Gen, Nadia Keller, et al., Paterson, David L, Nichaela Harbison-Price, David M. P. De Oliveira, Bohlmann, L., Paterson, D.L., De Oliveira, David MP, Jones, Thomas R, Harbison-Price, N., Mark von Itzstein, Bernhard Keller, McEwan, A.G., Keller, Bernhard, Ong, Cheryl-Lynn Y, Li, G., Walker, M.J., Stephan Brouwer, Jones, T.R., McDevitt, C.A., Cheryl-Lynn Y. Ong, Keller, N., Gen Li, Bohlmann, Lisa, Cork, Amanda J, Itzstein, M.V., De Oliveira, D.M.P., Turner, Andrew G, Hayes, Andrew J   +53 more
core   +1 more source

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii [PDF]

, 2016
Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. This study aimed to identify metabolic differences between polymyxin-susceptible and polymyxin-resistant A.
Forrest, A, Creek, DJ, Hertzog, Paul, Song, Jiangning, Purcell, AW, Kaye, Keith S., Li, J, Mahamad Maifiah, Mohd Hafidz, Kaye, KS, Song, J, Velkov, Tony, Creek, Darren J., Boyce, JD, Hertzog, P, Velkov, T, Cheah, Soon-Ee, Boyce, John D., Maifiah, MHM, Li, Jian, Maifiah, Mohd Hafidz Mahamad, Cheah, SE, Han, ML, Thamlikitkul, Visanu, Thamlikitkul, V, Johnson, MD, Johnson, Matthew D., Purcell, Anthony W., Han, Mei-Ling, Han, Meiling, Forrest, Alan   +29 more
core   +3 more sources