Results 41 to 50 of about 10,639 (243)

Nephrotoxicity of Polymyxins: A Multi-disciplinary Approach

, 2018
This thesis examined the mechanism of nephrotoxicity of the last-resort polymyxins using a systems approach. This study employed multiple complementary methods to investigate the accumulation of polymyxins in the kidneys and renal tubular cells, and ...
BO YUN (5147504)
core   +1 more source

Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria

BMC Infectious Diseases, 2005
Background The increasing problem of infections due to multidrug-resistant Gram-negative bacteria has led to re-use of polymyxins in several countries.
Bliziotis Ioannis A, Kasiakou Sofia K, Falagas Matthew E, Samonis George, Athanassopoulou Panayiota, Michalopoulos Argyris   +5 more
doaj   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Quantitative Determination of Major Active Components in Polymyxin B Medicinal Products by NMR Spectroscopy

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Polymyxin B is a natural multicomponent antibiotic used in its sulfate form for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. Pharmacopoeial standards for polymyxin B medicinal products include limits for
N. E. Kuz’mina, S. V. Moiseev, I. Yu. Yakupov, S. I. Kuleshova   +3 more
doaj   +1 more source

Polymyxins: Antibacterial activity, resistance mechanisms and epidemiology of plasmid mediated resistance [PDF]

Medicinski Podmladak, 2019
The occurrence and spreading of multi-resistant, as well as pan-resistant bacterial isolates, presents a global problem of modern medicine. Narrowed therapeutic options actualized the use of "old" antibiotics such as polymyxins.
Brkić Snežana, Božić Dragana, Ćirković Ivana   +2 more
doaj  

Extensively Drug-Resistant Hypervirulent Klebsiella pneumoniae From a Series of Neonatal Sepsis in a Tertiary Care Hospital, India

Frontiers in Medicine, 2021
The recent emergence of multidrug-resistant (MDR) Klebsiella pneumoniae with hypervirulent traits causing severe infections and considerable mortality is a global cause for concern. The challenges posed by these hypermucoviscous strains of K.
Tuhina Banerjee, Jayalaxmi Wangkheimayum, Swati Sharma, Ashok Kumar, Amitabha Bhattacharjee   +4 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity [PDF]

, 2023
The growing incidence of infections caused by multi-drug resistant Gram-negative bacteria has led to an increased use of last-resort antibiotics such as the polymyxins.
Wesseling, Charlotte M. J., Masereeuw, Rosalinde, Lysenko, Vladyslav, Barnes, Devon, Martin, Nathaniel I., Chaudhuri, Samhita, Slingerland, Cornelis J.   +6 more
core  

Potential Synergistic Antibiotic Combinations against Fluoroquinolone-Resistant Pseudomonas aeruginosa

Pharmaceuticals, 2022
The rise in multiple-drug-resistant (MDR) phenotypes in Gram-negative pathogens is a major public health crisis. Pseudomonas aeruginosa is one of the leading causes of nosocomial infections in clinics. Treatment options for P.
Ashish Kothari, Neeraj Jain, Shyam Kishor Kumar, Ankur Kumar, Karanvir Kaushal, Satinder Kaur, Atul Pandey, Amit Gaurav, Balram Ji Omar   +8 more
doaj   +1 more source