Results 41 to 50 of about 11,434 (195)

Polymyxins: Antibacterial activity, resistance mechanisms and epidemiology of plasmid mediated resistance [PDF]

Medicinski Podmladak, 2019
The occurrence and spreading of multi-resistant, as well as pan-resistant bacterial isolates, presents a global problem of modern medicine. Narrowed therapeutic options actualized the use of "old" antibiotics such as polymyxins.
Brkić Snežana, Božić Dragana, Ćirković Ivana   +2 more
doaj  

Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria

BMC Infectious Diseases, 2005
Background The increasing problem of infections due to multidrug-resistant Gram-negative bacteria has led to re-use of polymyxins in several countries.
Bliziotis Ioannis A, Kasiakou Sofia K, Falagas Matthew E, Samonis George, Athanassopoulou Panayiota, Michalopoulos Argyris   +5 more
doaj   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Quantitative Determination of Major Active Components in Polymyxin B Medicinal Products by NMR Spectroscopy

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Polymyxin B is a natural multicomponent antibiotic used in its sulfate form for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. Pharmacopoeial standards for polymyxin B medicinal products include limits for
N. E. Kuz’mina, S. V. Moiseev, I. Yu. Yakupov, S. I. Kuleshova   +3 more
doaj   +1 more source

Extensively Drug-Resistant Hypervirulent Klebsiella pneumoniae From a Series of Neonatal Sepsis in a Tertiary Care Hospital, India

Frontiers in Medicine, 2021
The recent emergence of multidrug-resistant (MDR) Klebsiella pneumoniae with hypervirulent traits causing severe infections and considerable mortality is a global cause for concern. The challenges posed by these hypermucoviscous strains of K.
Tuhina Banerjee, Jayalaxmi Wangkheimayum, Swati Sharma, Ashok Kumar, Amitabha Bhattacharjee   +4 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Potential Synergistic Antibiotic Combinations against Fluoroquinolone-Resistant Pseudomonas aeruginosa

Pharmaceuticals, 2022
The rise in multiple-drug-resistant (MDR) phenotypes in Gram-negative pathogens is a major public health crisis. Pseudomonas aeruginosa is one of the leading causes of nosocomial infections in clinics. Treatment options for P.
Ashish Kothari, Neeraj Jain, Shyam Kishor Kumar, Ankur Kumar, Karanvir Kaushal, Satinder Kaur, Atul Pandey, Amit Gaurav, Balram Ji Omar   +8 more
doaj   +1 more source

Resistance to polymyxins: genetic bases, epidemiology, and detection issues [PDF]

, 2017
Polymyxins are old designed antibiotics that have recently regained significant interest as a consequence of the increasing prevalence of infections due to multidrug-resistant Gram-negative bacteria.
Endimiani, Andrea
core   +1 more source

Impact of Colistin Dosing on the Incidence of Nephrotoxicity in a Tertiary Care Hospital in Saudi Arabia

Antibiotics, 2020
Colistin therapy is associated with the development of nephrotoxicity. We examined the incidence and risk factors of nephrotoxicity associated with colistin dosing.
Reem Almutairy, Waad Aljrarri, Afnan Noor, Pansy Elsamadisi, Nour Shamas, Mohammad Qureshi, Sherine Ismail   +6 more
doaj   +1 more source