Results 31 to 40 of about 11,434 (195)

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

Angewandte Chemie, EarlyView.
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll, Pia Lanvers, Giulia Ravagnan, Kilian Klaus, Olena Nosovska, Ivan Vilotijevic, Jochen Schmid, Hajo Kries   +7 more
wiley   +2 more sources

Review of the international consensus guidelines for the optimal use of the polymyxins [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2019
Polymyxins are often the only agents that remain in vitro active against extensively resistant bacterial pathogens. However, the use of polymyxins is compromised by the number of unresolved issues, including the technical aspects of antimicrobial ...
Eliseeva E.V., Azyzov I.S., Zubareva N.A.   +2 more
doaj   +1 more source

Neurodegenerative Disease Treatment Drug PBT2 Breaks Intrinsic Polymyxin Resistance in Gram-Positive Bacteria

Antibiotics, 2022
Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria.
David M. P. De Oliveira, Bernhard Keller, Andrew J. Hayes, Cheryl-Lynn Y. Ong, Nichaela Harbison-Price, Ibrahim M. El-Deeb, Gen Li, Nadia Keller, Lisa Bohlmann, Stephan Brouwer, Andrew G. Turner, Amanda J. Cork, Thomas R. Jones, David L. Paterson, Alastair G. McEwan, Mark R. Davies, Christopher A. McDevitt, Mark von Itzstein, Mark J. Walker   +18 more
doaj   +1 more source

Simeprevir restores the anti-Staphylococcus activity of polymyxins

, 2023
Methicillin-resistant Staphylococcus aureus (MRSA) infection poses a severe threat to global public health due to its high mortality. Currently, polymyxins are mainly used for the treatment of Gram-negative bacterial-related infection, while exhibiting ...
Pengfei She, Yao Duan, Zixin Liu, Huilong Li, Pingyun Wu, Ruolan Wu, Yuan Wu, Chaoni Cai, Di Zhang   +8 more
core   +1 more source

Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1 [PDF]

, 2021
Paenibacilli are efficient producers of potent agents against bacterial and fungal pathogens, which are of great interest both for therapeutic applications in medicine as well as in agrobiotechnology.
Vater, Joachim, Pascal Mülner, Schwarz, Elisa, Berg, Gabriele, Herfort, Stefanie, Peter Lasch, Lasch, Peter, Dietel, Kristin, Joachim Vater, Jähne, Jennifer, Cernava, Tomislav, Jennifer Jähne, Gabriele Berg, Mülner, Pascal, Elisa Schwarz, Kristin Dietel, Stefanie Herfort, Tomislav Cernava   +17 more
core   +1 more source

Antimicrobial Stewardship and Its Impact on the Changing Epidemiology of Polymyxin Use in a South Indian Healthcare Setting

Antibiotics, 2021
Polymyxins being last resort drugs to treat infections triggered by multidrug-resistant pathogens necessitates the implementation of antimicrobial stewardship program (ASP) initiatives to support its rational prescription across healthcare settings.
Dipu T. Sathyapalan, Jini James, Sangita Sudhir, Vrinda Nampoothiri, Praveena N. Bhaskaran, Nandita Shashindran, Jisha Thomas, Preetha Prasanna, Zubair Umer Mohamed, Fabia Edathadathil, Sanjeev Singh, Merlin Moni   +11 more
doaj   +1 more source

Nephrotoxicity of Polymyxins: A Multi-disciplinary Approach

, 2018
This thesis examined the mechanism of nephrotoxicity of the last-resort polymyxins using a systems approach. This study employed multiple complementary methods to investigate the accumulation of polymyxins in the kidneys and renal tubular cells, and ...
BO YUN (5147504)
core   +1 more source

Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Achromobacter Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide

Microbiology Spectrum, 2023
The Achromobacter genus includes opportunistic pathogens that can cause chronic infections in immunocompromised patients, especially in people with cystic fibrosis (CF). Treatment of Achromobacter infections is complicated by antimicrobial resistance. In
Lewis MacDonald, Sean Keenan, Flaviana Di Lorenzo, Nana E. Adade, Dervla T. D. Kenna, Beverley C. Millar, John E. Moore, José Ramos Vivas, Antonio Molinaro, Miguel A. Valvano   +9 more
doaj   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source