Results 31 to 40 of about 10,639 (243)
Simeprevir restores the anti-Staphylococcus activity of polymyxins
, 2023 Methicillin-resistant Staphylococcus aureus (MRSA) infection poses a severe threat to global public health due to its high mortality. Currently, polymyxins are mainly used for the treatment of Gram-negative bacterial-related infection, while exhibiting ...
Pengfei She +8 more
core +1 more source
Fusaricidins, Polymyxins and Volatiles Produced by Paenibacillus polymyxa Strains DSM 32871 and M1 [PDF]
, 2021 Paenibacilli are efficient producers of potent agents against bacterial and fungal pathogens, which are of great interest both for therapeutic applications in medicine as well as in agrobiotechnology.
Vater, Joachim +17 more
core +1 more source
Polymyxins resistance : an overview of molecular mechanisms and genetic determinants [PDF]
, 2021 Emergence of antimicrobial resistant bacteria is a majorworldwide public health issue. During the past decades, the misuse/overuse of antibiotics accelerated the development and dissemination of antimicrobial resistance, especially in multidrug-resistant
Cupertino, Victória Martins Lima
core
Advances in BODIPY Derivatives for Antibacterial Phototherapy
Angewandte Chemie, EarlyView.This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv +9 more
wiley +2 more sources
Review of the international consensus guidelines for the optimal use of the polymyxins [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2019 Polymyxins are often the only agents that remain in vitro active against extensively resistant bacterial pathogens. However, the use of polymyxins is compromised by the number of unresolved issues, including the technical aspects of antimicrobial ...
Eliseeva E.V. +2 more
doaj +1 more source
Antibiotics, 2022 Gram-positive bacteria do not produce lipopolysaccharide as a cell wall component. As such, the polymyxin class of antibiotics, which exert bactericidal activity against Gram-negative pathogens, are ineffective against Gram-positive bacteria.
David M. P. De Oliveira +18 more
doaj +1 more source
Antibiotics, 2021 Polymyxins being last resort drugs to treat infections triggered by multidrug-resistant pathogens necessitates the implementation of antimicrobial stewardship program (ASP) initiatives to support its rational prescription across healthcare settings.
Dipu T. Sathyapalan +11 more
doaj +1 more source
Polymyxins: “Last Resort” for MDR and/or XDR Gram-Negative Infections
, 2021 Polymyxins were used for the management of gram-negative infections in clinical practice science1940s. Parenteral administration waned in the seventies owing to polymyxins nephrotoxicity and neurotoxicity. Because of the lack of treatment choices for MDR
Ahmed, Manal Mohamed Elsayed +1 more
core +1 more source
Microbiology Spectrum, 2023 The Achromobacter genus includes opportunistic pathogens that can cause chronic infections in immunocompromised patients, especially in people with cystic fibrosis (CF). Treatment of Achromobacter infections is complicated by antimicrobial resistance. In
Lewis MacDonald +9 more
doaj +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source