Results 11 to 20 of about 11,434 (195)
The second life of polymyxins [PDF]
Клиническая микробиология и антимикробная химиотерапияPolymyxins are a well-known class of antimicrobial agents that have been used in clinical practice since the 1950s but lost their clinical significance for several decades.
Ageevets V.A.
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Polymyxins–Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment [PDF]
Antioxidants, 2020 The emergence of antimicrobial resistance in Gram-negative bacteria poses a huge health challenge. The therapeutic use of polymyxins (i.e., colistin and polymyxin B) is commonplace due to high efficacy and limiting treatment options for multidrug ...
Chongshan Dai +5 more
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Antibiotics, 2022 Polymyxins are considered a last-line treatment against infections caused by multidrug-resistant (MDR) Gram-negative bacteria. In addition to their use as a potent antibiotic, polymyxins have also been utilized as outer membrane (OM) permeabilizers ...
Danzel Marie Ramirez +4 more
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Pseudomonas aeruginosa MipA-MipB envelope proteins act as new sensors of polymyxins
mBioDue to the rising incidence of antibiotic-resistant infections, the last-line antibiotics, polymyxins, have resurged in the clinics in parallel with new bacterial strategies of escape.
Manon Janet-Maitre +9 more
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Structure–Interaction Relationship of Polymyxins with Lung Surfactant
, 2023 Multidrug-resistant Gram-negative bacteria present an urgent and formidable threat to the global public health. Polymyxins have emerged as a last-resort therapy against these ‘superbugs’; however, their efficacy against pulmonary infection is poor.
Yuwen Xu (1483303) +11 more
core +4 more sources
Polymyxins leading to nephrotoxicity [PDF]
, 2023 Drug resistance gram-negative bacteria are the most hazardous type of germ because they cause life-threatening illnesses. Polymyxins are cyclic lipodecapeptide antibiotics that are effective against gram-negative bacteria like Acinetobacter, Pseudomonas,
Lolla, Siddhartha +3 more
core +1 more source
Giant, 2023 Polymyxins are credited as the last line of defense against the clinical multi-resistant Gram-negative pathogen infections. However, their clinical use is limited by high nephrotoxicity and neurotoxicity, and less effectiveness against mature biofilms ...
Yongxin Yang +6 more
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Molecular epidemiology of mcr gene group [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Colistin and polymyxin B are the “last reserve” antimicrobials for the treatment of extensively drug-resistant Gram-negative bacterial infections. The rapidly increasing prevalence of polymyxin resistance mediated by the mcr gene localized on plasmid DNA
Shedko E.D. +2 more
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Comparative Neurotoxicity of Polymyxin B and Colistin in Patients With Cancer. [PDF]
PharmacotherapyABSTRACT Background The polymyxins, polymyxin B and colistin, are last‐line options for the treatment of infections caused by drug‐resistant gram‐negative organisms. The comparative neurotoxicity of these agents using contemporary dosing is poorly understood.
Aitken SL +3 more
europepmc +2 more sources
BMC Infectious Diseases, 2020 Background The prevalence of infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) is on the rise worldwide. Polymyxins are considered as last-resort drugs for CRAB infections, but there is still controversy regarding the efficacy and ...
Cheng Lyu +4 more
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