Results 11 to 20 of about 10,639 (243)
Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics [PDF]
Frontiers in Microbiology, 2019 The discovery of polymyxins, highly basic lipodecapeptides, was published independently by three laboratories in 1947. Their clinical use, however, was abandoned in the sixties because of nephrotoxicity and because better-tolerated drugs belonging to ...
Martti Vaara, Martti Vaara
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Microbiology Spectrum, 2023 High-alcohol-producing K. pneumoniae (HiAlc Kpn) causes nonalcoholic fatty liver disease (NAFLD) by producing excess endogenous alcohol in the gut of patients with NAFLD, using glucose as the main carbon source.
Zheng Fan +20 more
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The second life of polymyxins [PDF]
Клиническая микробиология и антимикробная химиотерапияPolymyxins are a well-known class of antimicrobial agents that have been used in clinical practice since the 1950s but lost their clinical significance for several decades.
Ageevets V.A.
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Polymyxins–Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment [PDF]
Antioxidants, 2020 The emergence of antimicrobial resistance in Gram-negative bacteria poses a huge health challenge. The therapeutic use of polymyxins (i.e., colistin and polymyxin B) is commonplace due to high efficacy and limiting treatment options for multidrug ...
Chongshan Dai +5 more
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Pseudomonas aeruginosa MipA-MipB envelope proteins act as new sensors of polymyxins
mBioDue to the rising incidence of antibiotic-resistant infections, the last-line antibiotics, polymyxins, have resurged in the clinics in parallel with new bacterial strategies of escape.
Manon Janet-Maitre +9 more
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Structure–Interaction Relationship of Polymyxins with Lung Surfactant
, 2023 Multidrug-resistant Gram-negative bacteria present an urgent and formidable threat to the global public health. Polymyxins have emerged as a last-resort therapy against these ‘superbugs’; however, their efficacy against pulmonary infection is poor.
Yuwen Xu (1483303) +11 more
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Molecular epidemiology of mcr gene group [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Colistin and polymyxin B are the “last reserve” antimicrobials for the treatment of extensively drug-resistant Gram-negative bacterial infections. The rapidly increasing prevalence of polymyxin resistance mediated by the mcr gene localized on plasmid DNA
Shedko E.D. +2 more
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Structures of Polymyxin B2 and Polymyxin E1 [PDF]
Nature, 1964 IN a previous communication1, from the analysis of a partial acid hydrolysate, the structure of polymyxin E1 was shown to be limited to two alternatives, the so-called 7 α and 8γ formulae. By applying the enzyme method of hydrolysis as devised by Suzuki et al. in their determinations of the structures of polymyxin B1 (ref. 2) and colistin A (ref.
S, WILKINSON, L A, LOWE
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Clinical Microbiology Reviews, 2008 SUMMARY The global emergence of multidrug-resistant gram-negative bacilli has spurred a renewed interest in polymyxins. Once discarded due to concerns regarding nephrotoxicity and neurotoxicity, polymyxins now hold an important role in the antibiotic armamentarium.
David, Landman +3 more
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BMC Infectious Diseases, 2020 Background The prevalence of infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) is on the rise worldwide. Polymyxins are considered as last-resort drugs for CRAB infections, but there is still controversy regarding the efficacy and ...
Cheng Lyu +4 more
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