Results 1 to 10 of about 310,698 (220)

Design, Synthesis, and Antitubercular Activity of Thiolutin–Cycloserine Hybrids: Reducing Cytotoxicity [PDF]

Microorganisms
The development of dual-acting hybrid antibiotics is a promising strategy to combat the ongoing spread of drug-resistant tuberculosis. Inspired by the structure of the natural dithiolopyrrolone hybrid antibiotic thiomarinol and based on the synergistic ...
Zhibin Sun, Xiaolong Chen, Shanfeng Shi, Yongqi Mu, Chuanxing Wan, Guoguo He   +5 more
doaj   +2 more sources

Thoracoscopic crush biopsy unmasking drug resistant extrapulmonary tuberculosis [PDF]

IDCases
Tuberculosis remains a major global health concern with extrapulmonary manifestations contributing to approximately 15–20% of cases in immune-competent hosts. In 2022, National Tuberculosis Elimination Program (NTEP) reported multidrug resistance in 2.5%
Poonam Patil, Babaji Ghewade, Ulhas Jadhav, Amit Toshniwal, Amisha Soni   +4 more
doaj   +2 more sources

Atypical mycobacterial infection at laparoscopic port site: Report of two cases indicating possibility of multi drug resistant strains in north-east India and review of literature [PDF]

IDCases
Atypical mycobacterial infections (AMIs), also known as nontuberculous mycobacterial (NTM) infections, are rare but important causes of postoperative port site infections following laparoscopic surgery.
Daisy Hazarika, Abhilash Goyal, Sankar Jyoti Bora, Bhupen Barman, Deb Kumar Boruah, Kalyan Sarma, Deepjyoti Kalita, Rajkumari Mazumdar, Anirban Bhattacharjee, Sayan Chakraborty, KS Santhosh Anand, Siva Kumar Shanmugam, Mukesh Kumar Sathya Narayanan, Anusuya Bhattacharyya, Pranjal Phukan, Phulen Sarma   +15 more
doaj   +2 more sources

An Atypical Presentation of Tuberculous Ascites, Severe Hyponatremia, and Acute Kidney Injury in a Young Male. [PDF]

Clin Case Rep
ABSTRACT A 25‐year‐old male who had been in good health before presenting with right lower lobe pneumonia, severe hyponatremia (Na 117 mEq/L), distension, and reduced urine output. AKI secondary to acute glomerulonephritis (GN) or interstitial nephritis was suggested by the initial workup. He was discharged for outpatient nephrology follow‐up following
Al Hariri B, Sharif M, Noor Illahi M, Eltigani AMA, Al Anbagi USM, Ahmad M.   +5 more
europepmc   +2 more sources

Essential role of MHC II in the antitubercular efficacy of pyrazinamide [PDF]

Antimicrobial Agents and Chemotherapy
Antibacterial drug mechanisms have traditionally been examined through a drug-pathogen lens, with limited attention to host influences on drug activity.
Elise A. Lamont, Shannon L. Kordus, Michael D. Howe, Ziyi Jia, Nathan Schacht, Muzafar Ahmad Rather, Gebremichal Gebretsadik, Anthony D. Baughn   +7 more
doaj   +2 more sources

Cutaneous tuberculosis with features suggestive of scrofuloderma masquerading as hidradenitis suppurativa: a case report [PDF]

Therapeutic Advances in Infectious Disease
Scrofuloderma is a form of cutaneous tuberculosis that results from the spread of infection from an underlying focus, most commonly lymph nodes or bone, to the overlying skin.
Midhun Raj, Tarun Kumar Suvvari, Vimal Thomas, Anand Krishnan R. G., Aishwarya Nitin Dnyate, Ryan Chris Thaddaeus, Noel Thomas Kandathil, Tejinder Singh   +7 more
doaj   +2 more sources

Drug induced liver injury: East versus West – a systematic review and meta-analysis [PDF]

Clinical and Molecular Hepatology, 2020
Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles.
En Xian Sarah Low, Qishi Zheng, Edwin Chan, Seng Gee Lim   +3 more
doaj   +1 more source

Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies.

PLoS ONE, 2022
A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods.
Surendra Babu Lagu, Rajendra Prasad Yejella, Srinath Nissankararao, Richie R Bhandare, Venu Sampath Golla, Bontha Venkata Subrahmanya Lokesh, M Mukhlesur Rahman, Afzal Basha Shaik   +7 more
doaj   +2 more sources

Synthesis of 2-(6-substituted quinolin-4-yl)-1-(4-aryl-1H-1,2,3-triazol-1-yl) propan-2-ol as potential antifungal and antitubercular agents

European Journal of Medicinal Chemistry Reports, 2023
The intense pressure of resistance to antibiotics leads the whole world's health security to drastic conditions due to Mycobacterial and fungal infections.
Abhijit Shinde, Prashant P. Thakare, Yogesh Nandurkar, Manish Bhoye, Abhijit Chavan, Pravin C. Mhaske   +5 more
doaj   +1 more source

A Case Report on Disseminated Tuberculosis in a Newborn [PDF]

Pediatric Infectious Disease, 2023
Congenital tuberculosis (CTB) is a rare and challenging diagnosis with high mortality. As one of the many differentials for newborn sepsis, it should be considered when neonates deteriorate despite broad-spectrum antibiotics.
Sachin Bhagat, Mangla Sood, Parveen Bhardwaj   +2 more
doaj   +1 more source